Fe (II) segregation at a specific crystallographic site of fibrous erionite: A first step toward the understanding of the mechanisms inducing its carcinogenicity

Ballirano, Paolo; Pacella, Alessandro; Cremisini, Carlo; Nardi, Elisa; Fantauzzi, Marzia; Atzei, Davide; Rossi, Antonella; Cametti, Georgia

doi:10.1016/j.micromeso.2015.02.046

Cited by 34 publications

(56 citation statements)

References 57 publications

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“…A potential carcinogenic hazard of offretite fibres has neither been confirmed nor dismissed so far and it remains unclear whether the mineralogical distinction between erionite and offretite has any health implications. Recently, the epidemiological, mineralogical and toxicological effects of erionite have been intensively investigated [12,[16][17][18][19][20][21][22][23][24][25]. Studies regarding erionite fibres were conducted on their interacting capability and the interactions with micelles and model membranes [26,27].…”

Section: Introductionmentioning

confidence: 99%

Real-Time Observation of Fibrous Zeolites Reactivity in Contact with Simulated Lung Fluids (SLFs) Obtained by Atomic Force Microscope (AFM)

et al. 2019

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Inhalation of fibrous erionite particles has been linked to malignant mesothelioma. Accordingly, erionite is considered the most carcinogenic mineral. The reactivity and the nature of erionite biotoxicity has been the subject of intensive research. Despite very close chemical and structural relationships between erionite and offretite, the reactivity of offretite in lung fluids remains unknown. In this paper, the interaction of erionite and offretite surfaces with simulated lung fluids was investigated by means of in situ atomic force microscope (AFM). To simulate different environments in the lungs, artificial lysosomal fluid (ALF) and Gamble's solution were used. In ALF (4.15 < pH < 4.31) the dissolution of erionite and offretite surfaces was detected, as well as an evident removal of particles (mainly attributed to impurities) from the crystal faces. Instead, the growth of a layer of a yet unknown phase on the surface of both zeolites was observed during the interaction with Gamble's solution (7.4 < pH < 8.48). The thickness of this layer reached a few tens of nanometers and covered all the observed areas. The understanding of the observed processes is of paramount importance, since they could be potentially involved in the mechanisms triggering the toxicological effects of erionite fibres.

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Section: Introductionmentioning

confidence: 99%

Real-Time Observation of Fibrous Zeolites Reactivity in Contact with Simulated Lung Fluids (SLFs) Obtained by Atomic Force Microscope (AFM)

et al. 2019

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“…Accordingly, it has been shown that an inhalable fiber might be carcinogenic if it is sufficiently durable to remain chemically and physically unaltered within the lung tissue [11]. In addition to biopersistence, the presence and structural coordination of Fe in the mineral fibers were proposed to play a key role in the carcinogenic mechanisms [12][13][14]. Other properties of fibers, including trace elements content, specific surface area, interacting capability, The samples FF102 and AD13 originated from Nogare (VI) and Fittà (VR), respectively, in the Lessini Mountains (northern Italy), where a thick sequence of lava flows of the Veneto Volcanic Province extensively crops out [60,61].…”

Section: Introductionmentioning

confidence: 99%

“…Starting structural model of offretite was taken from [68]. We adopted the same Rietveld refinement procedure used by the present research group in several structure refinements of erionite fibers [12,69]. Owing to the occurrence of correlations between site occupancy factors and displacement parameters, the latter were constrained as follows: B Si1 =B Si2 ; B O1 =B O2 =B O3 =B O4 =B O5 =B O6 ; B K1 =B Mg1 ; B Ca1 =B Ca2 ; B OW7 =B OW8 =B OW9 =B OW10 =B OW11 =B OW12 .…”

Section: Introductionmentioning

confidence: 99%

Prismatic to Asbestiform Offretite from Northern Italy: Occurrence, Morphology and Crystal-Chemistry of a New Potentially Hazardous Zeolite

et al. 2018

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A multi-methodological approach, based upon field investigation, morphological characterization, chemical analysis and structure refinement was applied to different samples of fibrous offretite, a new potentially hazardous zeolite recently discovered in northern Italy. Their morphology ranges from stocky-prismatic to asbestiform. All the investigated fibers may be considered as "inhalable", and they are well within the range of the "more carcinogenic fibers" regarding diameter. As regards the length, the main mode observed in the asbestiform samples is 20-25 µm, and~93% of the measured fibers are >5 µm and may be significantly associated with carcinogenesis also in terms of lengths. The chemical-structural features of the investigated fibers are comparable: the extra-framework cations K + , Mg 2+ and Ca 2+ are present in all samples in similar proportions, and refined cell parameters are similar among the samples. Offretite occurs in 60% of the investigated sites, with an estimated amount up to 75 vol % of the associated minerals. The presence of this mineral could be of concern for risk to human health, especially if one considers the vast number of quarries and mining-related activities that are operating in the zeolite host rocks.

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“…Oppositely, Fe 2+ -exchanged erionites have been obtained in laboratory2728. According to Ballirano et al 28,. Fe 2+ is fixed in the erionite cage and is six-fold coordinated to H 2 O molecules.…”

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Where is iron in erionite? A multidisciplinary study on fibrous erionite-Na from Jersey (Nevada, USA)

Gualtieri

Gandolfi

Pollastri

et al. 2016

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Fibrous erionite is a mineral fibre of great concern but to date mechanisms by which it induces cyto- and geno-toxic damage, and especially the role of iron associated to this zeolite species, remain poorly understood. One of the reasons is that we still don’t know exactly where iron is in natural erionite. This work is focused on fibrous erionite-Na from Jersey (Nevada, USA) and attempts to draw a general model of occurrence of iron in erionite and relationship with toxicity mechanisms. It was found that iron is present as 6-fold coordinated Fe3+ not part of the zeolite structure. The heterogeneous nature of the sample was revealed as receptacle of different iron-bearing impurities (amorphous iron-rich nanoparticles, micro-particles of iron oxides/hydroxides, and flakes of nontronite). If iron is not part of the structure, its role should be considered irrelevant for erionite toxicity, and other factors like biopersistence should be invoked. An alternative perspective to the proposed model is that iron rich nano-particles and nontronite dissolve in the intracellular acidic environment, leaving a residue of iron atoms at specific surface sites anchored to the windows of the zeolite channels. These sites may be active later as low nuclearity groups.

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Fe (II) segregation at a specific crystallographic site of fibrous erionite: A first step toward the understanding of the mechanisms inducing its carcinogenicity

Cited by 34 publications

References 57 publications

Real-Time Observation of Fibrous Zeolites Reactivity in Contact with Simulated Lung Fluids (SLFs) Obtained by Atomic Force Microscope (AFM)

Real-Time Observation of Fibrous Zeolites Reactivity in Contact with Simulated Lung Fluids (SLFs) Obtained by Atomic Force Microscope (AFM)

Prismatic to Asbestiform Offretite from Northern Italy: Occurrence, Morphology and Crystal-Chemistry of a New Potentially Hazardous Zeolite

Where is iron in erionite? A multidisciplinary study on fibrous erionite-Na from Jersey (Nevada, USA)

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