Fe-Doped MoS₂ Nanozyme for Antibacterial Activity and Detoxification of Mustard Gas Simulant

Abstract

The peroxidase-like catalytic activity of various nanozymes was extensively applied in various fields. In this study, we have demonstrated the preparation of Fe-doped MoS2 (Fe@MoS2) nanomaterials with enhanced peroxidase-like activity of MoS2 in a co-catalytic pathway. In view of Fenton reaction, the peroxidase-like Fe@MoS2 nanozyme prompted the decomposition of hydrogen peroxide (H2O2) to a reactive hydroxyl radical (·OH). The efficient decomposition of H2O2 in the presence of Fe@MoS2 has been employed toward the antibacterial activity and detoxification of mustard gas simulant. The combined effect of Fe@MoS2 and H2O2 showed remarkable antibacterial activity against the drug-resistant bacterial strain methicillin-resistant Staphylococcus aureus and Escherichia coli with the use of minimal concentration of H2O2. Fe@MoS2 was further applied for the detoxification of the chemical warfare agent sulfur mustard simulant, 2-chloroethyl ethyl sulfide, by selective conversion to the nontoxic sulfoxide. This work demonstrates the development of a hybrid nanozyme and its environmental remediation from harmful chemicals to microbes.

pH-Switchable phenylalanine-templated copper nanoclusters: CO2 probing and efficient peroxidase mimicking activity

“…To confirm the generation of ROS, we have performed fluorimetric measurements using terephthalic acid (TA), a well-known • OH radical scavenger. 58 In the presence of the • OH radical, TA forms 2-hydroxyterephthalic acid (TAOH), whose presence is confirmed by monitoring the fluorescence peak at 427 nm, upon excitation at 315 nm (Fig. 7e).…”

MoO2 and N-Doped Carbon Nano-Octahedron Nanozymes for Sensitive Detection of Alkaline Phosphatase

“…It is seen from the figure that the peak shape of MoO 2 @NPC is similar to that of MoO 3 , but its binding energy is low. The interaction of carbon and exposed oxygen generates the C–O bond (Figure g), which regulates the electronic valence state of Mo to between Mo 5+ and Mo 6+ , thus causing the Mo 3d spectrum to move in the direction of low binding energy. , The existence of Mo 6+ is due to the fact that at 650 °C, just at the critical temperature of MoO 2 transition, the material body has been transformed into MoO 2 @NPC nano-octahedron, but due to the anchoring effect of carbon on the surface, a thin layer of MoO 3 crystal structure is anchored on the surface of the material. As a result, XRD results show the characteristic peak of MoO 2 .…”

Amorphous Fe-Containing Phosphotungstates Featuring Efficient Peroxidase-like Activity at Neutral pH: Toward Portable Swabs for Pesticide Detection with Tandem Catalytic Amplification

“…As discussed in Figure 1G,H there are two redox couples (Fe 2+ /Fe 3+ and W 5+ /W 6+ ) in the prepared Fe-PTs, which can facilitate the regeneration of Fe 2+ by capturing electrons from the W 6+ species. 43,44 Moreover, the high surface electron density of polyoxotungstate clusters in Fe-PTs can also accelerate the reduction of Fe 3+ to Fe 2+ (Figure 2D). 45 The two pathways synergistically promote the decomposition of H 2 O 2 into hydroxyl radicals.…”