FDG Uptake in a Catheter-Related Thrombus Simulating Relapse of Lymphoma

Siösteen, Anna‐Karin; Celsing, Fredrik; Jacobsson, Hans

doi:10.1097/01.rlu.0000159680.66566.b7

Cited by 21 publications

(47 citation statements)

References 8 publications

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“…Miceli et al [12] suggested that 18 F-FDG accumulated in all cases of thrombophlebitis but not in deep venous thrombosis. In earlier literature, it has been reported that 18 F-FDG may accumulate in neutrophils and macrophages in the area of infl ammation and may not accumulate in non-infl ammatory clot and organizing clot [8,10]. We consider that it may be possible to distinguish between tumor thrombus and venous thrombus.…”

mentioning

confidence: 78%

“…We consider that it may be possible to distinguish between tumor thrombus and venous thrombus. 18 F-FDG uptake has been reported to be seen in catheter-related thrombus [10,13]. However, this phenomenon occurred because of infl ammatory change of the venous wall stimulated by the catheter.…”

mentioning

confidence: 97%

“…However, recently an intravascular thrombus has been described in the literature as both FDG avid and photopenic, and especially, 18 F-FDG has been reported to accumulate in thrombophlebitis and catheter-related thrombus, as well as tumor thrombus [10][11][12][13][14].…”

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confidence: 98%

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Tumor thrombus in the inferior vena cava from colon cancer detected by 18F-FDG-PET

et al. 2007

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We present a case of inferior vena cava (IVC) tumor thrombus detected by fluorine- 18 fluorodeoxyglucose positron emission tomography (18F-FDG-PET). A man underwent operations for the treatment of sigmoid colon cancer at the age of 63. Because tumor markers [carcinoembryonic antigen (CEA) and CA19-9] were increased at the age of 67, abdominal contrast-enhanced computed tomography (CT) was performed. CT revealed IVC dilatation, including a low-attenuation area. 18F-FDG-PET was performed to make the differential diagnosis between tumor thrombus and clot. 18F-FDG-PET showed that 18F-FDG had accumulated in the IVC region. We considered the IVC tumor thrombus because of the 18F-FDG uptake in the IVC region and the patient's clinical course. To our knowledge, there are a few reports concerning 18F-FDG-PET and IVC tumor thrombus. 18F-FDG-PET may be useful in diagnosing tumor thrombus.

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confidence: 78%

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confidence: 97%

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Tumor thrombus in the inferior vena cava from colon cancer detected by 18F-FDG-PET

et al. 2007

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“…It is known that tumour thrombus shows increased 18 F-FDG uptake resulting from the increased glycolytic rate in malignant cells. Nevertheless, there are a few cases in the literature with acute venous thrombosis or thrombophlebitis that may cause pathological uptake of 18F-FDG PET [2,3,[6][7][8], although these cases usually demonstrate only "modest 18 F-FDG PET uptake" [9].…”

Section: Discussionmentioning

confidence: 99%

Adrenal metastasis of breast cancer with involvement of the inferior vena cava

Sarabia¹,

García²,

Escarcena³

et al. 2008

Clin Transl Oncol

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Tumour thrombosis of the inferior cava vein is usually associated with primary renal cell cancer. To our knowledge, this is the first case reported of adrenal metastasis of breast cancer extending into the inferior vena cava. There are few references in the literature documenting this extension with positron emission tomography (PET) and enhanced computed tomography (CT). The authors focus on the role of combined PET-CT imaging in the accurate detection of malignant thrombus.

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“…Radiolabeled 18 F‐Sodium Fluoride (Na 18 F) was then prepared from the acquired 18 F in‐house as described in the literature 9, 10. Briefly, the process began with 18 F‐fluoride and 0.1 ml H 18 O diluted with 5 ml sterile water and passed through a cation exchange (in the form of H + ) cartridge connected to a Waters Corporation Sep‐Pak Accell Plus QMA cartridge (Milford, MA, USA).…”

Section: Methodsmentioning

confidence: 99%

Assessment of radiopharmaceutical retention for vascular access ports using positron emission tomography imaging

Gossman¹,

Zheng

Evans

et al. 2017

J Applied Clin Med Phys

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PurposeThe purpose of this study was to resolve the issue of whether various generations of CR Bard peripheral vascular access ports and catheters are prone to retain PET radiopharmaceuticals. The study evaluates the residual radioactivity remaining following injection for two PET radiopharmaceuticals currently used extensively in the clinic, FDG and Na18F.Methods FDG was purchased from a local cyclotron facility and Na18F was prepared in‐house. Three generations of currently marketed vascular access ports were tested. A total of five (n = 5) of each model was tested. Radiopharmaceutical of 2–3 mCi of each was injected into each port and flushed with 10, 30, 60, and 120 ml of saline. MicroPET scans were performed after each flush to detect the residual radioactivity on each port. A dose calibrator was used to detect the retention of radioactivity after each flush.ResultsRadioactivity retention for all vascular port models measured by microPET imaging was similar for both FDG and Na18F, with less than 1% residual activity following a 10 ml saline flush. Based on the microPET images, all the subsequent flushes of 30, 60, and 120 ml were also considered. Dose calibrator activity measurements validated microPET measurements as negligible for all the ports, even with the first 10 ml flush.ConclusionsMicroPET imaging was more sensitive than the dose calibrator in determining the radioactivity retention of the vascular access ports from CR Bard. These ports may be used for the injection of FDG and Na18F to track glucose metabolism and bone uptake with PET imaging. It is recommended to apply at least a 10 ml flush after radiopharmaceutical administration, to reduce residual activity to baseline levels.

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FDG Uptake in a Catheter-Related Thrombus Simulating Relapse of Lymphoma

Cited by 21 publications

References 8 publications

Tumor thrombus in the inferior vena cava from colon cancer detected by 18F-FDG-PET

Tumor thrombus in the inferior vena cava from colon cancer detected by 18F-FDG-PET

Adrenal metastasis of breast cancer with involvement of the inferior vena cava

Assessment of radiopharmaceutical retention for vascular access ports using positron emission tomography imaging

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