FDG PET of Alveolar Soft Part Sarcoma

Montgomery, Justin R.; Conrad, Gary; Sinha, Partha; Absher, Kimberly J.

doi:10.1097/rlu.0b013e3181ef0b57

Cited by 9 publications

(4 citation statements)

References 15 publications

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“…Both the primary and metastatic ASPS in our study demonstrated variable FDG uptake, which is in agreement with the previously reported single case (SUVmax, 1.8-5.9). 28 The SUVmax values are also similar to other soft-tissue sarcomas. A review of 212 patients of sarcomas (both osseous and softtissue sarcomas) revealed the mean SUVmax value of the primary and/or the most avid metastatic lesion in the positive cases to range from 5.6 to 23.2 (median, 9.9), with most lesions having an SUVmax .2.5.…”

Section: Resultssupporting

confidence: 62%

Imaging features of primary and metastatic alveolar soft part sarcoma: single institute experience in 25 patients

Sood¹,

Baheti²,

Shinagare³

et al. 2014

BJR

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Objective: To describe imaging features of primary and metastatic alveolar soft part sarcoma (ASPS). Methods: In this institutional review board-approved and Health Insurance Portability and Accountability Actcompliant retrospective study, 25 patients (14 males; mean age, 25 years; range, 18-40 years) with pathologically proven ASPS seen at our institute between 1995 and 2013 were included. Imaging of primary tumours in 5 patients and follow-up imaging in 25 patients were reviewed by 2 radiologists in consensus. Clinical information was obtained from electronic medical records. Results: The most common sites for the primary tumour were extremities (17/25, 68%) and torso (6/25, 24%). Primary tumours (n 5 5) were well circumscribed, compared with skeletal muscle, were isodense on CT, hyperintense on T 1 and T 2 weighted images with intense post-contrast enhancement, prominent feeders on CT and flow voids on MRI. Metastases developed in 23/25 (92%) patients, 18 at presentation. The most common sites of metastases were the lungs (100%), lymph nodes (74%), bones (57%) and brain (43%). Visceral and nodal metastases were hypervascular. At the time of reporting the results, 15 patients have died, 6 are alive and 4 were lost to follow-up. Median survival was 74 months for those without brain metastases (n 5 8) and 60 months for those with brain metastases (n 5 7). Median survival was shorter for patients with metastases at presentation. Conclusion: ASPS most commonly involves the lower extremities of young adults, is hypervascular on imaging, often metastasizes at presentation, frequently to lung, nodes, bones and brain, and has an indolent course despite metastases. Brain metastases and high tumour burden (number of metastatic sites) at presentation decreased survival in our study. Advances in knowledge: ASPS has an unusual pattern of metastases to the brain and nodes in addition to lung and bones. It has an indolent course despite metastases.

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Section: Resultssupporting

confidence: 62%

Imaging features of primary and metastatic alveolar soft part sarcoma: single institute experience in 25 patients

Sood¹,

Baheti²,

Shinagare³

et al. 2014

BJR

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“…To the best of our knowledge, there are no previous reports regarding FDG uptake in a case of orbital ASPS. The maximum FDG uptake of SUV in patients with ASPS in other body parts is 1.8 -10.1 [22][23][24][25] . A previous study reported the presence of thrombosed tumor vessels [3] .…”

Section: Discussionmentioning

confidence: 95%

Alveolar soft part sarcoma of the orbit: A case report

Oda¹,

Kikuchi²,

Togao³

et al. 2021

Radiology Case Reports

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“…Our case also demonstrated the presence of numerous collateral vessels in the tumor and in the peritumoral region in addition to the renal artery and vein with variceal changes. The PET-CT facilitated the differentiation of the primary lesion from metastatic lesions in the presence of multiple masses at the time of initial diagnosis (6). In this case, the highest FDG uptake (max SUV = 6.4) was observed in the mass of the left kidney.…”

Section: Discussionmentioning

confidence: 99%

Alveolar Soft Part Sarcoma Arising from the Kidney: Imaging and Clinical Features

Kim

et al. 2014

Korean J Radiol

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Alveolar soft part sarcoma (ASPS) is an extremely rare malignant soft tissue sarcoma primarily affecting young patients. It usually occurs in the lower extremities, although it can occur in soft tissue anywhere in the body. However, to our knowledge, there has been no case of primary ASPS originating from the kidney in the literature. We herein present the imaging and clinical features of an ASPS which occurred in a 16-year-old male presented as a palpable mass in the left side of the abdomen.

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FDG PET of Alveolar Soft Part Sarcoma

Cited by 9 publications

References 15 publications

Imaging features of primary and metastatic alveolar soft part sarcoma: single institute experience in 25 patients

Imaging features of primary and metastatic alveolar soft part sarcoma: single institute experience in 25 patients

Alveolar soft part sarcoma of the orbit: A case report

Alveolar Soft Part Sarcoma Arising from the Kidney: Imaging and Clinical Features

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