FDG-PET in the detection of gastrointestinal metastases in melanoma

Tatlidil, Rozet; Mandelkern, M.

doi:10.1097/00008390-200106000-00012

Cited by 29 publications

(13 citation statements)

References 11 publications

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“…The usefulness of FDG-PET in recurrent tumors other than these primary tumors of the esophagus, stomach, and intestine has also reported [15,16], encouraging expectations that FDG-PET will also be useful for the detection of metastatic tumors of the gastrointestinal tract. A few studies have reported metastatic tumors of the gastrointestinal tract and the use of FDG-PET in gastrointestinal metastases [17,18]. Studies have reported on 124 patients with gastrointestinal metastasis from lung cancer, 106 of whom were diagnosed on the occasion of serious complications such as perforation [3,19].…”

Section: Casementioning

confidence: 99%

Metastasis of the gastrointestinal tract: FDG-PET imaging

et al. 2007

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We assess the usefulness of F-18-fluoro-deoxyglucose (FDG) positron emission tomography (PET) in the evaluation of gastrointestinal metastases. Four cases (five lesions) in which metastases from three lung cancers and one malignant fibrous histiocytoma (MFH) of the femur were found in the gastrointestinal tract were reviewed (men/women 3 : 1, age 63-78 years, mean 72 years). The five lesions were duodenal, jejunal metastasis, and two stomach metastases from lung carcinoma, and rectal metastasis from MFH of the femur. FDG-PET was unable to detect small masses, but it was able to detect unforeseen lesions such as gastrointestinal metastases because FDG-PET is a whole-body scan in a single-operation examination. FDG-PET imaging provided valuable information for the diagnosis of gastrointestinal metastasis.

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Section: Casementioning

confidence: 99%

Metastasis of the gastrointestinal tract: FDG-PET imaging

et al. 2007

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“…They were diagnosed by using endoscopy, upper GI barium series, barium enema or abdominal CT. In case of a history of malignant melanoma, some authors recommend magnetic resonance imaging (MRI) as it depicts the location and nature of the melanotic foci due to signal changes whereas the others propose positron emission tomography (PET)-CT due to the high metabolic consumption of 18 fluoroglucose that helps to locate the lesions [11,12] . Surgery is treatment of choice in case of metastases as the surgical resection not only enhances survival but also improves quality of life [10,13] .…”

Section: Discussionmentioning

confidence: 99%

Ileocecal intussusception due to the intestinal metastasis of malignant melanoma

Öziş

Ataç

Sahli

et al. 2014

CRCP

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Intestinal obstruction due to ileocecal intussusception is very rare in adult age. Primary and secondary tumors, inflammatory or proliferative processes of the bowel are the causative factors. Malignant melanoma is a common disease in the western world with high metastatic rates, and is also a common extra-abdominal source of gastrointestinal metastases.We present a 55-year-old woman with the complaints of an abrupt colicky abdominal pain, nausea and vomiting. Her history revealed cutaneous melanoma that was excised five years ago. Her physical examination revealed abdominal distention with generalized abdominal tenderness. Multidetector computed tomography (MDCT) revealed a mass at ileocecal junction with dilatation of entire small bowel segments. Metastasis was confirmed by laparotomy. After a right-sided hemicolectomy, patient died of disease with widespread metastasis with of one year after colectomy.

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“…PET combined with CT imaging (PET‐CT) has become a major diagnostic tool in the detection of metastatic disease, as the technique improves the identification of deep soft tissue, lymph node and visceral metastases 15,16 . PET‐CT has been also proposed as the method of choice in detecting gastrointestinal melanoma metastases, which frequently are underdiagnosed by standard endoscopic techniques 17,18 . However, small metastatic deposits need to achieve a certain size to be detected by PET‐CT 15 .…”

Section: Discussionmentioning

confidence: 99%

“…15,16 PET-CT has been also proposed as the method of choice in detecting gastrointestinal melanoma metastases, which frequently are underdiagnosed by standard endoscopic techniques. 17,18 However, small metastatic deposits need to achieve a certain size to be detected by PET-CT. 15 In this case, the diagnosis of metastatic melanoma was particularly challenging. While the presence of widely disseminated small pigmented lesions appearing in crops in a patient with a previous diagnosis of melanoma suggested epidermotropic metastatic melanoma as a possibility, a staging evaluation (including a PET-CT) was negative for distant metastatic disease.…”

Section: Discussionmentioning

confidence: 99%

Intraepidermal epidermotropic metastatic melanoma: a clinical and histopathological mimicker of melanoma in situ occurring in multiplicity

Lestre

João

Ponte

et al. 2011

Journal of Cutaneous Pathology

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Journal of Cutaneous PathologyIntraepidermal epidermotropic metastatic melanoma: a clinical and histopathological mimicker of melanoma in situ occurring in multiplicityThe distinction between primary melanoma and melanoma metastatic to the skin has major prognostic implications. We report a case of a 67-year-old male with a diagnosis of a superficial spreading melanoma (stage IB) rendered 6 years earlier who presented clinically with an atypical nevus on his left thigh. Histopathological examination showed an intraepidermal melanocytic proliferation that was interpreted as melanoma in situ. Subsequently, 45 additional pigmented macules appeared in crops over a 9-month period. Clinically and dermoscopically, these lesions were extremely polymorphic. Histopathological findings were compatible with melanoma in situ, as each lesion consisted of a wholly intraepidermal proliferation of markedly atypical melanocytes arranged singly and in nests. A complete gastrointestinal study showed multiple pigmented metastatic lesions throughout the stomach and small bowel, which supported a diagnosis of metastatic melanoma with gastrointestinal and epidermotropic skin involvement. Monosomy of chromosome 9 and a BRAF V600E mutation were detected in the primary tumor sample and in macro-dissected secondary lesions. No CDKN2A or CDK4 germline mutations were found. Intraepidermal epidermotropic metastases of melanoma have been rarely described in literature. In this case, histopathology alone was insufficient to distinguish metastatic melanoma from multiple in situ melanomas. The recognition of epidermotropic metastases should be based on the correlation between clinical, dermoscopic, histopathological and molecular findings.

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FDG-PET in the detection of gastrointestinal metastases in melanoma

Cited by 29 publications

References 11 publications

Metastasis of the gastrointestinal tract: FDG-PET imaging

Metastasis of the gastrointestinal tract: FDG-PET imaging

Ileocecal intussusception due to the intestinal metastasis of malignant melanoma

Intraepidermal epidermotropic metastatic melanoma: a clinical and histopathological mimicker of melanoma in situ occurring in multiplicity

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