FDG-PET imaging and the diagnosis of non-small cell lung cancer in a region of high histoplasmosis prevalence

Croft, Donita R.; Trapp, J. Douglas; Kernstine, Kemp H.; Kirchner, Peter T.; Mullan, Brian F.; Galvin, Jeffery R.; Peterson, Michael W.; Groß, Thomas; McLennan, Geoffrey; Kern, Jeffrey A.

doi:10.1016/s0169-5002(02)00023-5

Cited by 100 publications

(45 citation statements)

References 8 publications

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“…Most patients with cancer and acute histoplasmosis in this study were male, although this proportion was not statistically different from the proportion in the population of patients with cancer cared for during the study period (P = .190; expected number of boys among 33 patients, [13][14][15][16][17][18][19][20][21][22][23][24][25]. A similar preponderance of male patients has been found by serosurveys of healthy children and those undergoing evaluation for mediastinal masses.…”

Section: Discussionsupporting

confidence: 60%

“…Careful evaluation must continue until imaging methods that can distinguish between malignant and benign pulmonary lesions reduce the need for invasive procedures. 24 Differentiation between histoplasmosis and malignancy in children with mediastinal masses is also a chronic problem for pediatricians. In a study of 37 children who were from a region endemic for histoplasmosis and who had mediastinal masses, Gaebler et al found no useful demographic feature, laboratory result, or radiologic finding for distinguishing between these groups except for a CF yeast or mycelial titer $1:32.…”

Section: Discussionmentioning

confidence: 99%

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Histoplasmosis in a pediatric oncology center

Adderson

2004

The Journal of Pediatrics

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Histoplasmosis in a pediatric oncology center

Adderson

2004

The Journal of Pediatrics

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“…Increased MIBI uptake in aspergilloma and granuloma due to silicosis has not yet been described. These false-positive results show similar limitations for MIBI as are known for PET [4,6,17].…”

Section: Discussionsupporting

confidence: 72%

Solitary pulmonary nodule evaluation with 99mTc-methoxy isobutyl isonitrile in a tuberculosis-endemic area

Schuurmans¹,

Ellmann²,

Bouma³

et al. 2007

European Respiratory Journal

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High prevalence of tuberculosis increases the odds for nonmalignant solitary pulmonary nodules (SPNs). Positron emission tomography (PET) using 18 F-fluorodeoxyglucose is the method of choice for the identification of malignant SPNs requiring curative surgery. However, PET is not widely available. Technetium-99m methoxy isobutyl isonitrile (MIBI) is inexpensive, widely available and shows increased uptake in malignant SPNs. The aim of the present study was to prospectively evaluate the diagnostic value of MIBI single photon emission computed tomography to distinguish between benign and malignant SPNs in a tuberculosis-endemic area.In total, 49 patients with radiologically indeterminate SPNs (single lesion f6 cm in diameter) were prospectively evaluated with MIBI. The final diagnosis was established with bronchoscopy, fine-needle aspiration, surgical resection or clinical follow-up for o2 yrs.A total of 12 (92%) out of 13 malignant lesions showed increased uptake of MIBI, while no uptake was observed in 33 (92%) out of 36 benign lesions. MIBI uptake indicated malignancy with a sensitivity and specificity of 92% and a negative predictive value of 97%.In this tuberculosis-endemic area, technetium-99m methoxy isobutyl isonitrile single photon emission computed tomography evaluation of solitary pulmonary nodules had a high negative predictive value. Therefore, it has the potential to prevent unnecessary surgical resections of benign nodules and serve as a low-cost alternative when positron emission tomography is not available.

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“…Focal lesions also exhibit increased FDG uptake. Therefore, such lesions maybe mistaken for lung cancer on PET/CT, and imaging does not reduce the need for diagnostic biopsy [50][51][52][53].…”

Section: Endemic Fungi and Cryptococcusmentioning

confidence: 99%

Radiologic Imaging Techniques for the Diagnosis and Management of Invasive Fungal Disease

Hanson

Caligiuri

Wiggins

et al. 2015

Curr Fungal Infect Rep

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Invasive fungal diseases (IFDs) are an important cause of morbidity and mortality, especially in immunocompromised patients. Prompt antifungal therapy is essential for favorable outcomes, but clinical signs and symptoms are nonspecific and mycologic confirmation is often not possible. Radiographic testing is an important adjunct to the diagnosis and management of IFDs. Early imaging has been associated with improved survival, particularly in neutropenic patients with fungal pneumonia or acute invasive fungal sinusitis. This review summarizes common radiologic appearances of IFDs of the lung, sinus, and brain. The advantages and limitations of computed tomography (CT) and magnetic resonance (MR) imaging are discussed as are recent developments in nuclear medicine and proton MR spectroscopy technology.

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FDG-PET imaging and the diagnosis of non-small cell lung cancer in a region of high histoplasmosis prevalence

Cited by 100 publications

References 8 publications

Histoplasmosis in a pediatric oncology center

Histoplasmosis in a pediatric oncology center

Solitary pulmonary nodule evaluation with 99mTc-methoxy isobutyl isonitrile in a tuberculosis-endemic area

Radiologic Imaging Techniques for the Diagnosis and Management of Invasive Fungal Disease

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