FDG-PET/CT in Skeletal Muscle: Pitfalls and Pathologies

Parida, Girish Kumar; Roy, Shambo Guha; Kumar, Rakesh

doi:10.1053/j.semnuclmed.2017.02.003

Cited by 36 publications

(26 citation statements)

References 102 publications

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“…The imaging diagnoses in this study were based on the detection of abnormal SUVs in the various anatomical locations that matched the primary presenting clinical signs. One of the challenges of FDG PET imaging has been to correctly differentiate abnormal uptake from normal physiological uptake or nonpathologic variants/artifacts . To minimize false‐positive assessments, the observer must be familiar with these possible variants of physiological radiopharmaceutical uptake.…”

Section: Discussionmentioning

confidence: 99%

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Fluorine‐18‐fluoro‐2‐deoxy‐d‐glucose PET‐CT aids in detection of soft‐tissue injuries for dogs with thoracic or pelvic limb lameness

Frank

Mann

Duerr

2019

Vet Radiology Ultrasound

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Fluorine-18-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) provides physiologic images of tissues based on their glucose metabolism. The combination of FDG PET and CT (FDG PET-CT) has been utilized in human musculoskeletal imaging to localize soft tissue lesions, however, this modality has not been thoroughly investigated for the diagnosis of canine lameness. This prospective, descriptive study evaluated FDG PET-CT findings in 25 client-owned dogs with inconclusive origin of thoracic or pelvic limb lameness (thoracic limb n = 15/25, 60%; pelvic limb n = 6/25, 24%; and combination of both limbs n = 4/25, 16%). We hypothesized that FDG PET-CT would aid the detection of soft tissue lesions not visible with other imaging modalities. Combined FDG PET-CT detected soft tissue lesions in 40% (n = 10/25) and osteoarthritis in 64% (n = 16/25) of the patients. FDG PET detected more soft tissue lesions than contrastenhanced CT (n = 15/15, 100% and n = 12/15, 80%, respectively), while CT identified more osteoarthritis lesions than FDG PET (n = 26/26, 100% and n = 18/26, 69%, respectively). The three imaging-diagnoses based on the FDG PET component included the following: flexor carpi ulnaris muscle tear, psoas major myopathy, and tarsal desmopathy. No diagnosis for the lameness was obtained in three dogs. Findings supported FDG PET-CT as a useful adjunct imaging modality for detection of certain soft tissue injuries of the musculoskeletal system. Combined FDG PET-CT should be considered for cases where the cause of lameness is thought to be of soft tissue origin and cannot be diagnosed by conventional means. K E Y W O R D S functional imaging, myopathy, PET tracer, SUVmax, tendinopathy

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Section: Discussionmentioning

confidence: 99%

“…This results in a buildup of FDG in highly metabolic tissues that exhibit high glucose consumption to sustain their metabolic activity. Thereby, increased glucose utilization by activated inflammatory cells allows FDG PET to identify musculoskeletal pathology …”

Section: Introductionmentioning

confidence: 99%

Fluorine‐18‐fluoro‐2‐deoxy‐d‐glucose PET‐CT aids in detection of soft‐tissue injuries for dogs with thoracic or pelvic limb lameness

Frank

Mann

Duerr

2019

Vet Radiology Ultrasound

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“…Muscle metabolic glucose uptakes were observed to be decreased after treatment, though the basal levels could not be interpreted since FDG has never been used to evaluate muscle metabolism before. In a review, the determinants of muscle metabolism and their reflections in 18-FDG PET/CT were assessed, with suggestions and precautions towards increased uptakes and their considerations as being pathological or non-pathological (Parida, 2017 Survival was reported to be related with sarcopenia in patients with cancer, since survival is a measure of paramount interest in studies of all types of cancer (Gokyer, 2019;Hopanci bicakli, 2019;Nakamura, 2015Nakamura, , 2019Ozawa, 2019). In our study, we observed a relation with sarcopenia and survival both in terms of CT-based and FDG-based metabolic evaluation, which suggested the utility of metabolic evaluation in muscle assessment in MM.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of Sarcopenia with F‐18 FDG PET/CT and relation with disease outcomes in patients with multiple myeloma

et al. 2020

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Multiple myeloma (MM) is characterised with the neoplastic production of clonal plasma cells which produce a monoclonal immunoglobulin. Accounting for 1%-2% of all cancers and more than 15% of haematological malignancies in the United States, worldwide incidence of MM is reported as 160.000/year with 106.000 deaths/year (Bray, 2018; Siegel, 2019). Median age of patients with MM at diagnosis is 66 years, and only 2% of patients are younger than 40 years. Most patients present with symptoms related with anaemia, hypercalcaemia, bone pain, renal disease and constitutional symptoms including fatigue and weight loss (Cowan, 2016). The standard of care for the bone disease of MM has evolved from plain radiographs to more sophisticated modalities, spinal magnetic resonance (MR), position emission tomography/computerised tomography (PET/CT), whole-body CT or MRI, and more recently, PET/ CT with novel agents against the pathophysiology of bone disease of MM, pentixafor PET/CT (Pan, 2020). Sarcopenia is defined as loss of skeletal muscle mass and is an important health problem generally related with ageing

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“…Physiologic skeletal muscle FDG uptake has been described,[ 2 ] most commonly in the head and neck areas[ 3 ] resulting from voluntary muscular activity[ 4 ] or involuntary activity such as stress-induced muscle tension or spasm. [ 5 6 7 8 ] The physiologic uptake of FDG in temporal and masseter muscles, in this case, might be explained by subconscious muscular tension, although the patient did not report any symptom, or by voluntary activity such as clenching teeth.…”

Section: Discussionmentioning

confidence: 99%

Temporal muscle uptake causing an unusual focal artifact on three-dimensional stereotactic surface projections statistical maps of (18F) fluorodeoxyglucose brain positron emission tomography in a patient with Alzheimer's disease

Thientunyakit

Minoshima

2020

World J Nucl Med

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( 18 F) fluorodeoxyglucose brain positron emission tomography and statistical mapping analysis, such as three-dimensional stereotactic surface projections, have been used widely for the evaluation of dementia patients. We present an unusual focal artifact on the statistical maps resulting from intense temporal muscle uptake in a patient with Alzheimer’s disease. Various degrees of physiologic uptake can be seen in head and neck muscles. However, it is unusual to see a focal artifact on the statistical maps due to temporal muscle uptake. This case illustrates the importance of quality control of imaging processing when atypical findings are seen on statistical maps.

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FDG-PET/CT in Skeletal Muscle: Pitfalls and Pathologies

Cited by 36 publications

References 102 publications

Fluorine‐18‐fluoro‐2‐deoxy‐d‐glucose PET‐CT aids in detection of soft‐tissue injuries for dogs with thoracic or pelvic limb lameness

Fluorine‐18‐fluoro‐2‐deoxy‐d‐glucose PET‐CT aids in detection of soft‐tissue injuries for dogs with thoracic or pelvic limb lameness

Evaluation of Sarcopenia with F‐18 FDG PET/CT and relation with disease outcomes in patients with multiple myeloma

Temporal muscle uptake causing an unusual focal artifact on three-dimensional stereotactic surface projections statistical maps of (18F) fluorodeoxyglucose brain positron emission tomography in a patient with Alzheimer's disease

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