FDG-PET/CT for the Preoperative Lymph Node Staging of Invasive Bladder Cancer

Swinnen, Greet; Maes, Alex; Pottel, Hans; Vanneste, A.; Billiet, Ignace; Lesage, Karl; Werbrouck, Patrick

doi:10.1016/j.eururo.2009.05.014

Cited by 155 publications

(88 citation statements)

References 20 publications

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“…PET using fluorine-18 fluorodeoxyglucose ( 18 F-FDG) is a well-established imaging tool for detection of malignancy [8][9][10][11][12]. Inflammatory cells and tumor cells share a similar molecular basis of 18 F-FDG uptake, for example overexpression of glucose transporter (GLUT-1 and GLUT-3) and glycolytic enzymes.…”

Section: Introductionmentioning

confidence: 99%

Determinants of diagnostic performance of 18F-FDG PET/CT in patients with fever of unknown origin

Pereira¹,

Husmann²,

Sah³

et al. 2016

Nuclear Medicine Communications

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OBJECTIVES There is uncertainty about patient selection and the adequate timing at which fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) is indicated in the diagnostic work-up of fever of unknown origin (FUO). The aim of this study was to determine the diagnostic performance of F-FDG PET/CT in patients with FUO. METHODS All consecutive patients who underwent F-FDG PET/CT at the University Hospital Zurich because of FUO between 2006 and 2012 were included in this retrospective, observational study. RESULTS A total of 76 patients [70% men, median (interquartile range) age 60 (47-67) years] were included. F-FDG PET/CT showed characteristically increased F-FDG activity in 56 patients (74%), leading to confirmation of or change in the suspected cause of FUO in 57 and 17%, respectively. The final diagnosis after F-FDG PET/CT included infection (21%), malignancy (22%), noninfectious inflammatory disease (12%), others (5%), or an unknown cause (40%). The success rate, sensitivity, and specificity of F-FDG PET/CT were 60, 77, and 31%, respectively. Sensitivity was highest in patients with suspected malignancy (100%, 95% confidence interval 79-100%). Diagnostic performance was independent of the investigated variables other than suspected infection as a cause of FUO (odds ratio 0.1, 95% confidence interval 0.01-0.8, P=0.033). CONCLUSION The diagnostic performance of F-FDG PET/CT was significantly higher in patients with suspected malignancy causing a FUO compared with suspected infection or noninfectious inflammatory disease. However, it was independent of the baseline characteristics and duration of fever. This supports the recommendation to perform F-FDG PET/CT early in the diagnostic work-up of FUO, which may shorten disease duration and lower health costs, particularly when infection or malignancy is suspected.

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Section: Introductionmentioning

confidence: 99%

Determinants of diagnostic performance of 18F-FDG PET/CT in patients with fever of unknown origin

Pereira¹,

Husmann²,

Sah³

et al. 2016

Nuclear Medicine Communications

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show abstract

“…Karbon (C) kolin veya C-methionin gibi mesaneye ekskresyonu daha az olan diğer radyoizotoplar ile yapılan çalışmalarda primer tümör gösterilebilmekte ise de bu radyoizotopların tanıya ve evrelemeye katkısı gösterilememiştir (8,11,20). PET-BT ile yapılan çalışmalar göstermiştir ki mesane kanseri nodal evrelemesinde kontrastlı BT'ye göre üstünlüğünü, primer tümör tanısında ve lokal evrelemede gösterememektedir (21,22,23).…”

Section: Pozitron Emisyon Tomografi-bilgisayarlı Tomografiunclassified

The Role of Radiology in Perivesical Invasion of Muscle-Invasive Bladder Cancer

Öz¹,

Mungan²

2016

uob

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“…The optimum or specific isotope for studying bladder cancer has not yet been determined (34 (15,(35)(36)(37)(38). FDG is still the most widely used isotope to investigate bladder cancer (34).…”

Section: Transurethral Resectionmentioning

confidence: 99%

“…The molecular and immunologic profile of UBC may be characterized so as to select patients who will benefit from different therapeutic approaches. Additionally, the available methods for staging remain inaccurate and further studies are needed to improve the staging techniques (12)(13)(14)(15)(16)(17)(18).…”

Section: Background Introduction To Bladder Cancermentioning

confidence: 99%

Staging and tumor biological mechanisms of lymph node metastasis in invasive urinary bladder cancer

Aljabery¹

2017

Linköping University Medical Dissertations

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Aim: To study the possibility of detecting lymph node metastasis in locally advanced urinary bladder cancer (UBC) treated with radical cystectomy (RC) by using preoperative positron emission tomography/computed tomography (PET/CT) and peroperative sentinel node biopsy (SNB) technique. We also investigate the clinical significance of macrophage traits expression by cancer cells, M2-macrophage infiltration (MI) in tumor stroma and the immunohistochemical expression of biomarkers in cancer cells in relation to clinico-pathologic data. Patients and Methods:We studied prospectively 122 patients with UBC, pathological stage pT1-pT4 treated with RC and pelvic lymph node dissection (PLND) during [2005][2006][2007][2008][2009][2010][2011] at the Department of Urology, Linköping University Hospital. In the first study, we compared the results of preoperative PET/CT and conventional CT with the findings of postoperative histopathological evaluation of lymph nodes (LNs). In the second study we investigated the value of SNB technique for detecting pathological LNs during RC in patients with UBC. We also examined the significance of the primary tumor location in the bladder in predicting the site of LN metastases, and the prognostic significance of lympho-vascular invasion (LVI) and lymph node metastasis density (LNMD) on survival. In the third study, we investigate the clinical significance of macrophage infiltration (MI) in tumor stroma and macrophage-traits expression by tumor cells. In the fourth study, we investigate the cell cycle suppression pro-

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FDG-PET/CT for the Preoperative Lymph Node Staging of Invasive Bladder Cancer

Cited by 155 publications

References 20 publications

Determinants of diagnostic performance of 18F-FDG PET/CT in patients with fever of unknown origin

Determinants of diagnostic performance of 18F-FDG PET/CT in patients with fever of unknown origin

The Role of Radiology in Perivesical Invasion of Muscle-Invasive Bladder Cancer

Staging and tumor biological mechanisms of lymph node metastasis in invasive urinary bladder cancer

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