FDG PET/CT Findings of Multifocal Epithelioid Hemangioendotheliomas of the Bones

Rao, Maohua; Chen, Yue; Huang, Zhanwen; Zhu, Yan; Xiao, Xiuli

doi:10.1097/rlu.0000000000000810

Cited by 10 publications

(4 citation statements)

References 25 publications

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“…Four out of five patients underwent contrast-enhanced T1WI, all showing obvious enhancement. Considering some EH patients present with multiple lesions and more than one organ involved, PET/CT is a useful imaging method for evaluating it (11,12). However, due to the rarity of this disease, 18 F-FDG PET/CT features of the thoracic spine and even bones are rarely described in the literature.…”

Section: Discussionmentioning

confidence: 99%

CT, MRI, and PET/CT imaging features of thoracic spine epithelioid hemangioma: a retrospective observational study

Hu,

Li,

Xiong

et al. 2024

Front. Oncol.

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IntroductionEpithelioid hemangioma (EH) is an intermediate locally aggressive tumor that consists of epithelioid cells and endothelial cell differentiation, which can occur at any age, but is most common between the ages of 30 and 40 years. EH in the thoracic spine is rare, and accurate diagnosis is critical to treatment planning. Our aim was to explore the imaging and clinical data of thoracic spine EH to improve the understanding of this rare disease.MethodsFrom January 1, 2018 to June 30, 2023, a database of thoracic spine masses was retrospectively reviewed. Five patients with histologically proven thoracic spine EH and complete imaging available were identified and analyzed. Computed tomography (CT) and magnetic resonance imaging (MRI) findings were evaluated separately by two radiologists with more than 10 years of experience. Positron emission tomography (PET)/CT was conducted by two nuclear medicine diagnostic technologists with at least 5 years of experience.ResultsThe patients included three male and two female patients aged 23 to 56 years (mean age was 38.4 ± 14.3 years). All patients underwent CT, MRI, and 18F-FDG PET/CT examination before treatment. Four patients were limited to one vertebral involvement, only one patient had multiple vertebral involvement, and all tumors involved the accessories, including one involving the posterior ribs. The maximum diameter of the tumor ranged from 2.7 to 4.3.ConclusionsCT, MRI, and 18F-FDG PET/CT findings of thoracic spine EH have certain characteristics, and understanding these imaging findings will help to obtain accurate diagnosis before surgery.

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Section: Discussionmentioning

confidence: 99%

CT, MRI, and PET/CT imaging features of thoracic spine epithelioid hemangioma: a retrospective observational study

Hu,

Li,

Xiong

et al. 2024

Front. Oncol.

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“…Considering most EHE patients present with multiple lesions and more than one organ involved, 3,4 PET/CT represents a useful imaging modality for evaluation of EHE. In previous studies, EHE demonstrates variable, but most commonly moderate 18 F-FDG uptake on PET/CT 5,6 . Besides 18 F-FDG PET/CT, 68 Ga-DOTATATE and 68 Ga-FAPI PET/CT also demonstrated increased radiotracer uptake in the EHE lesions 7,8 .…”

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confidence: 81%

“…In previous studies, EHE demonstrates variable, but most commonly moderate 18 F-FDG uptake on PET/CT. 5,6 Besides 18 F-FDG PET/CT, 68 Ga-DOTATATE and 68 Ga-FAPI PET/CT also demonstrated increased radiotracer uptake in the EHE lesions. 7,8 In this case, 68 Ga-FAPI PET/CT revealed higher radiotracer uptake and a greater number of osseous lesions than 18 F-FDG in a patient with metastatic EHE.…”

Section: Figurementioning

confidence: 93%

68Ga-FAPI Versus 18F-FDG PET/CT in the Evaluation of Epithelioid Hemangioendothelioma of Bone

Cai²,

Meng³

et al. 2023

Clin Nucl Med

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Epithelioid hemangioendothelioma (EHE) is a rare type of vascular tumor that may arise in bone. Here we presented a 62-year-old man with suspected bone metastases who underwent PET/CT to detect the primary tumor. He underwent 18 F-FDG and 68 Ga-FAPI PET/CT under the prospective trial NCT04416165. Radiotracer uptake was much higher with 68 Ga-FAPI PET/CT than with 18 F-FDG PET/CT in most of bone lesions. No intense uptake likely presenting the primary tumor was observed. Subsequent bone biopsy confirmed the diagnosis of EHE of bone. This case suggested that 68 Ga-FAPI PET/CT might be a useful tool for evaluation of EHE.

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Section: Discussionmentioning

confidence: 99%

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FDG PET/CT Findings of Multifocal Epithelioid Hemangioendotheliomas of the Bones

Abstract: Epithelioid hemangioendothelioma of the bones is very rare. We report a 78-year-old patient suffering from epithelioid hemangioendothelioma of multiple pelvic bones and the right femur. FDG PET/CT scan showed intense activity in mainly lytic lesions of these bones.

Cited by 10 publications

References 25 publications

CT, MRI, and PET/CT imaging features of thoracic spine epithelioid hemangioma: a retrospective observational study

CT, MRI, and PET/CT imaging features of thoracic spine epithelioid hemangioma: a retrospective observational study

68Ga-FAPI Versus 18F-FDG PET/CT in the Evaluation of Epithelioid Hemangioendothelioma of Bone

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