2017
DOI: 10.1097/rlu.0000000000001580
|View full text |Cite
|
Sign up to set email alerts
|

FDG PET/CT Assesses the Risk of Femoral Pathological Fractures in Patients With Metastatic Breast Cancer

Abstract: Purpose Assessment of pathological fracture risk is critical to optimize the use of prophylactic orthopedic fixation to prevent pathological fractures. Better prediction of pathological fracture risk is needed. We evaluated if quantitative measures of FDG-avidity can assess femoral pathological fracture risk in patients with metastatic breast cancer (MBC). Methods A HIPAA-compliant retrospective case-control study was performed under IRB waiver. Patients with MBC who received an FDG PET/CT from 1/2008–12/201… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
8
0

Year Published

2018
2018
2022
2022

Publication Types

Select...
8
1

Relationship

1
8

Authors

Journals

citations
Cited by 15 publications
(8 citation statements)
references
References 23 publications
0
8
0
Order By: Relevance
“…van der Linden et al advise to use 3-cm cortical involvement as a cutoff point [5,27]. The most promising are CT-based algorithms that are currently being developed [25]. Once such models will be able to provide quick predictions in the clinical setting, hopefully the everlasting question of how to determine the fracture risk will belong to the past.…”
Section: Discussionmentioning
confidence: 99%
“…van der Linden et al advise to use 3-cm cortical involvement as a cutoff point [5,27]. The most promising are CT-based algorithms that are currently being developed [25]. Once such models will be able to provide quick predictions in the clinical setting, hopefully the everlasting question of how to determine the fracture risk will belong to the past.…”
Section: Discussionmentioning
confidence: 99%
“…Prophylactic internal fixation of pathological subtrochanteric fractures due to metastatic lesions has to be considered in cases of increasing pain [7]. Fluorodeoxyglucose (FDG)-positron emission tomography (PET) may help identify breast cancer patients at high risk of subsequent pathological fracture of the proximal femur [25]. In the future, CT scan-based finite element (FE) analysis may provide a useful tool for identification of impending pathological fractures requiring prophylactic stabilization [11,22].…”
Section: Resultsmentioning
confidence: 99%
“…Antiresorptive agents, including primarily bisphosphonates and denosumab, play an important role in decreasing pain and preventing skeletal events but do not obviate the need for mechanical stabilization [11,36]. Scoring systems have been established and validated to predict completion of impending pathologic fractures in long bones, but a clinical algorithm does not exist for the pelvis, where the decision to pursue surgical treatment is based on the surgeon's clinical assessment, training, and experience [13,17,33,47].…”
Section: Navigation For Fixation Of Pelvic Metastasesmentioning
confidence: 99%