FDG-PET/CT, a Promising Exam for Detecting High-Risk Myeloma Patients?

Michaud-Robert, Anne-Victoire; Jamet, Bastien; Bailly, Clément; Carlier, Thomas; Moreau, Philippe; Touzeau, Cyrille; Bourgeois, Mickaël; Bodet-Milin, Caroline

doi:10.3390/cancers12061384

Cited by 6 publications

(4 citation statements)

References 45 publications

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“…18 F-FDG PET/CT exhibits superior sensitivity and specificity for SBP lesions. It can detect minimal residual disease inside and outside the bone marrow at the same time in one examination, which cannot be identified by χ-ray and magnetic resonance imaging[ 41 , 42 ]. In the early stages of patients with SBP after RT, 18 F-FDG PET/CT performs poorly in disease staging; however, a high SUV max value is a regular prognostic indicator for progression[ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Solitary hyoid plasmacytoma with unicentric Castleman disease: A case report and review of literature

Zhang¹,

He²,

Hao³

et al. 2022

World J Clin Cases

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BACKGROUND Solitary plasmacytoma and unicentric Castleman disease (UCD) are rare lymphoproliferative disorders characterized by monoclonal plasma cells and a single set of locally enlarged lymph nodes, respectively. CASE SUMMARY A 48-year-old Han Chinese man presented to our department with a neck mass and progressive foreign body sensation in his throat. 18 F-FDG positron emission tomography revealed focally increased radioactivity centered around the hyoid, and computed tomography (CT) revealed osteolytic lesions. Histopathology revealed Castleman-like features and CD138/CD38-positive mature plasma cells. Systemic work-up ruled out the possibility of POEMS syndrome, lymphoma, and multiple myeloma, leading to a final diagnosis of solitary hyoid plasmacytoma with UCD. The patient underwent partial hyoid resection and selective neck dissection, followed by intensity-modulated radiotherapy. 99mTc-MDP single-photon emission computed tomography/CT reevaluation showed neither local recurrence nor distant bone metastasis at the 40-mo follow-up. CONCLUSION The diagnostic process and differential diagnosis of this rare case provided valuable educational information to clinicians.

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Section: Discussionmentioning

confidence: 99%

Solitary hyoid plasmacytoma with unicentric Castleman disease: A case report and review of literature

Zhang¹,

He²,

Hao³

et al. 2022

World J Clin Cases

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“…It has been included in the 2019 International Myeloma Working Group (IMWG) recommendations as a feasible imaging strategy for the initial workup of newly diagnosed MM. FDG-PET/CT detects myeloma-related lesions with excellent sensitivity and specificity with the advantage of carrying out both bone and extra-bone exploration in a single examination [ 36 – 38 ].…”

Section: Positron Emission Tomography With Computed Tomography 18f-de...mentioning

confidence: 99%

“…The performance of FDG-PET/CT in detecting MM is excellent, with a sensitivity of around 90% for the detection of myeloma lesions, and specificity was varying from 70 to 100% in several studies, with greater sensitivity than whole-body conventional radiography and comparable sensitivity with pelvic-spinal MRI. PET/CT detects more osseous myeloma manifestations in 40%–60% of cases as compared to conventional radiography and detects lesions in patients with false-negative conventional radiography results [ 23 , 36 , 44 ].…”

Section: Positron Emission Tomography With Computed Tomography 18f-de...mentioning

confidence: 99%

Modern imaging techniques in the monitoring of patients with multiple myeloma

Pop

Tomoaia

Pârvu

2022

Medicine and Pharmacy Reports

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Bone disease for many patients is a serious problem, often causing pathological bone fractures; a spinal collapse, in conclusion, is a disease that affects the quality of life. It is the most frequent feature of multiple myeloma (MM), and it is used to put a diagnostic and the need to start treatment. Because of these complications, imaging plays a vital role in the diagnosis and workup of myeloma patients. For many years, the conventional radiography has long been considered the gold standard for detecting bone lesions. The main reasons are the wide availability, the low cost, the relatively low radiation dose, and the ability of this imaging method to cover the entire bone system. Because of its incapacity to evaluate the response therapy, more sophisticated techniques such as whole-body low-dose computed tomography (WBLDCT), whole-body magnetic resonance imaging, and 18F-fluorodeoxyglucose–positron emission tomography/computed tomography (PET/CT). In this review, some of the advantages, indications of use, and applications of the three techniques in managing patients with MM will be discussed. The European Myeloma Network guidelines have recommended WBLDCT as the imaging modality of choice for the initial assessment of MM-related lytic bone lesions. Magnetic resonance imaging is the gold-standard imaging modality for the detection of bone marrow involvement. One of the modern imaging methods and PET/CT can provide valuable prognostic data and is the preferred technique for assessing response to therapy.

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“…The past decade has seen considerable advances in developing risk classifiers based on cytogenetics and gene expression profiling ( 6), but spatial heterogeneity can limit the sensitivity of these tests because they are based on cells obtained from a single bone marrow biopsy. Several 18 F-FDG PET/CT characteristics could be defined as possible high-risk biomarkers and could be used to define high-risk patients at the initial diagnosis of symptomatic MM (7). 18 F-FDG PET/CT is equally beneficial for patients with solitary plasmacytoma to detect medullary and extramedullary lesions (8,9) and has a prognostic value for patients with smoldering MM (10,11).…”

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confidence: 99%