FDA-Approved Amoxapine Effectively Promotes Macrophage Control of Mycobacteria by Inducing Autophagy

Wang, Jia; Sha, Jian; Strong, Emily; Chopra, Ashok K.; Lee, Sunhee

doi:10.1128/spectrum.02509-22

Cited by 8 publications

(4 citation statements)

References 44 publications

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“…90 Various drugs, including isoniazid and pyrazinamide (first-line tuberculosis drugs) and other compounds and plants mentioned in previous studies, have been reported to target and activate host autophagy. 91,92 Recent studies have shown a variety of old remedies to be remarkably effective in warding off infections, including clonamine, 91 the antidepressant drug amoxapine, 93 and so on. Berbamine (BBM), an FDA-approved drug, inhibits drug-sensitive and resistant Mtb growth by promoting macrophage autophagy.…”

Section: Therapeutic Strategies Targeting Host Autophagymentioning

confidence: 99%

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Host‐pathogen dialogues in different cell death modes during Mycobacterium tuberculosis infection

Ruan,

Lyu,

Lai

et al. 2024

Interdisciplinary Medicine

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Tuberculosis (TB) is a fatal infectious disease that continues to pose a serious public health threat. The emergence of drug‐resistant TB has further worsened the burden of the disease. The interaction between the host and the pathogen involves multiple modes of cell death, which play a role in determining immune outcomes. Several studies have established a strong correlation between cell death and TB progression. This review explores the molecular mechanisms of various cell death modes in Mycobacterium tuberculosis (Mtb) infection and how Mtb's virulence effectors regulate these pathways, including apoptosis, autophagy, pyroptosis, ferroptosis, and necrosis. Furthermore, therapeutic strategies targeting cell death pathways have shown promising results in TB treatment. Importantly, this review highlights the significant potential of mitochondria in mediating communication between different cell death modes and influencing the final outcomes. Overall, this work provides a comprehensive summary of the role of cell death in host immune responses and immune evasion by Mtb. It also offers valuable insights into the pathogenesis of TB and immune evasion strategies employed by Mtb and contributes to the development of more effective anti‐TB therapies.

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Section: Therapeutic Strategies Targeting Host Autophagymentioning

confidence: 99%

“…Recent studies have shown a variety of old remedies to be remarkably effective in warding off infections, including clonamine, 91 the antidepressant drug amoxapine, 93 and so on. Berbamine (BBM), an FDA‐approved drug, inhibits drug‐sensitive and resistant Mtb growth by promoting macrophage autophagy.…”

Section: Autophagymentioning

confidence: 99%

Host‐pathogen dialogues in different cell death modes during Mycobacterium tuberculosis infection

Ruan,

Lyu,

Lai

et al. 2024

Interdisciplinary Medicine

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“…In contrast, the antiprotozoal drug nitazoxanide has been found to strongly stimulate autophagy while inhibiting mTOR signaling 377 . Additionally, the antidepressant amoxapine has demonstrated the ability to induce autophagy and protect macrophages during infection 378 . The anticonvulsant drugs carbamazepine and valproic acid, meanwhile, can induce mTOR‐independent autophagy through AMPK activation, a unique characteristic that sets them apart from other drugs 379 .…”

Section: Host‐directed Therapymentioning

confidence: 99%

“… 377 Additionally, the antidepressant amoxapine has demonstrated the ability to induce autophagy and protect macrophages during infection. 378 The anticonvulsant drugs carbamazepine and valproic acid, meanwhile, can induce mTOR‐independent autophagy through AMPK activation, a unique characteristic that sets them apart from other drugs. 379 MET, the antidiabetic drug, has been reported to significantly reduce intracellular Mtb growth in an AMPK‐dependent manner.…”

Section: Host‐directed Therapymentioning

confidence: 99%

Mycobacterium tuberculosis: Pathogenesis and therapeutic targets

Yang,

Zhang,

Qiao

et al. 2023

MedComm

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Tuberculosis (TB) remains a significant public health concern in the 21st century, especially due to drug resistance, coinfection with diseases like immunodeficiency syndrome (AIDS) and coronavirus disease 2019, and the lengthy and costly treatment protocols. In this review, we summarize the pathogenesis of TB infection, therapeutic targets, and corresponding modulators, including first‐line medications, current clinical trial drugs and molecules in preclinical assessment. Understanding the mechanisms of Mycobacterium tuberculosis (Mtb) infection and important biological targets can lead to innovative treatments. While most antitubercular agents target pathogen‐related processes, host‐directed therapy (HDT) modalities addressing immune defense, survival mechanisms, and immunopathology also hold promise. Mtb’s adaptation to the human host involves manipulating host cellular mechanisms, and HDT aims to disrupt this manipulation to enhance treatment effectiveness. Our review provides valuable insights for future anti‐TB drug development efforts.

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Recognition of Mycobacterium tuberculosis by macrophage Toll-like receptor and its role in autophagy

Wei,

Liu,

Meng

et al. 2024

Inflamm. Res.

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FDA-Approved Amoxapine Effectively Promotes Macrophage Control of Mycobacteria by Inducing Autophagy

Cited by 8 publications

References 44 publications

Host‐pathogen dialogues in different cell death modes during Mycobacterium tuberculosis infection

Host‐pathogen dialogues in different cell death modes during Mycobacterium tuberculosis infection

Mycobacterium tuberculosis: Pathogenesis and therapeutic targets

Recognition of Mycobacterium tuberculosis by macrophage Toll-like receptor and its role in autophagy

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