Fcγ receptor type IIIA is associated with rheumatoid arthritis in two distinct ethnic groups

Morgan, Ann W; Griffiths, Bridget; Ponchel, Frédérique; Montague, B.; Ali, Manir; Gardner, Philip P.; Gooi, H. C.; Situnayake, R D; Markham, Alexander F.; Emery, Paul; Isaacs, John D.

doi:10.1002/1529-0131(200010)43:10<2328::aid-anr21>3.0.co;2-z

Cited by 87 publications

(76 citation statements)

References 37 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While the HLA region has been the genomic region most strongly associated with RA, it is estimated to explain only 30-40% of the genetic risk (84,85), emphasizing the importance of other genes in disease susceptibility and severity. Besides the influence of single genes, interaction between genes may also be important, and results of preliminary studies support interactions of the SE with polymorphisms of tumor necrosis factor (86,87) and Fc␥ receptor IIIA (88).…”

Section: Discussionmentioning

confidence: 90%

Impact of shared epitope genotype and ethnicity on erosive disease: A meta‐analysis of 3,240 rheumatoid arthritis patients

Gorman¹,

Lum²,

Chen³

et al. 2004

Arthritis & Rheumatism

130

View full text Add to dashboard Cite

Objective. The strongest known genetic association in rheumatoid arthritis (RA) is with HLA-DRB1 alleles that share a similar amino acid sequence, termed the shared epitope (SE). Although many studies have examined the association of the SE with disease severity, the results have been inconsistent, which may reflect the relatively small sample sizes or ethnic differences. The aim of this study was to assess the association of HLA-DRB1 SE alleles and genotype with the development of bony erosions in RA by meta-analysis.Methods. We identified English-language articles published between January 1, 1987 and June 1, 1999 through Medline, EMBase, and manual searches of 6 relevant journals. Included were studies in which molecular typing of HLA-DRB1 alleles was performed and in which the presence or absence of bony erosions was reported. Data were extracted from the studies, and erosions were coded as present or absent. Authors were contacted for missing information and data on individual patients.Results. A total of 29 studies and 3,240 patients were available for analysis. The summary odds ratios Conclusion. The SE is associated with the

show abstract

Section: Discussionmentioning

confidence: 90%

Impact of shared epitope genotype and ethnicity on erosive disease: A meta‐analysis of 3,240 rheumatoid arthritis patients

Gorman¹,

Lum²,

Chen³

et al. 2004

Arthritis & Rheumatism

130

View full text Add to dashboard Cite

show abstract

“…A previous case-control positive association of homozygosity for FcgRIIIA Phe158 with RA has been reported, 4 but results are conflicting. 20,21 The present study has been performed with three different groups of RA patients. For the transmission analysis, the 58 Spanish families of the European Consortium on RA families (ECRAF) were analysed.…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms in Spanish rheumatoid arthritis patients: an association and linkage study

et al. 2003

View full text Add to dashboard Cite

“…6 In humans, only a limited number of studies have been reported on the association of FCGR polymorphisms with RA. In Caucasians living in southern Spain, 7 in the United Kingdom (UK), 8 and in North Indians/ Pakistanis,…”

Section: Introductionmentioning

confidence: 99%

Studies on the association of Fcγ receptor IIA, IIB, IIIA and IIIB polymorphisms with rheumatoid arthritis in the Japanese: evidence for a genetic interaction between HLA-DRB1 and FCGR3A

Kyogoku

Tsuchiya

Matsuta³

et al. 2002

Genes Immun

View full text Add to dashboard Cite

We recently detected a new single nucleotide polymorphism of FcgRIIB gene, which alters an amino acid within the transmembrane domain from Ile to Thr (I232T), and its association with SLE in the Japanese. This study was performed to examine whether FCGR2B-I232T was associated with susceptibility to rheumatoid arthritis in the Japanese. At the same time, FCGR2A, 3A and 3B polymorphisms were also examined. Genotyping of FCGR2B-I232T, FCGR2A-H131R, FCGR3A-F176V and FCGR3B-NA1/2 polymorphisms were performed using genomic DNA. Association with RA was analyzed in 382 Japanese patients with RA and 303 healthy individuals using a case-control approach. In addition, the same groups of patients and controls were genotyped for HLA-DRB1 to examine possible interaction with FCGR genes. Significantly different distribution of genotype, allele carrier and allele frequencies was not observed between patients with RA and healthy individuals in any of the four polymorphisms. When the subjects were stratified according to the carriage of HLA-DRB1 shared epitope (SE), significant increase of FCGR3A-176F/F genotype was observed in SE positive patients compared with SE positive healthy individuals (P ¼ 0.009, P corr ¼ 0.07). In conclusion, FCGR3A-176F/F genotype was considered to confer risk through genetic interaction with HLA-DRB1 SE.

show abstract

Fcγ receptor type IIIA is associated with rheumatoid arthritis in two distinct ethnic groups

Cited by 87 publications

References 37 publications

Impact of shared epitope genotype and ethnicity on erosive disease: A meta‐analysis of 3,240 rheumatoid arthritis patients

Impact of shared epitope genotype and ethnicity on erosive disease: A meta‐analysis of 3,240 rheumatoid arthritis patients

Genetic polymorphisms in Spanish rheumatoid arthritis patients: an association and linkage study

Studies on the association of Fcγ receptor IIA, IIB, IIIA and IIIB polymorphisms with rheumatoid arthritis in the Japanese: evidence for a genetic interaction between HLA-DRB1 and FCGR3A

Contact Info

Product

Resources

About