FcRγ deficiency improves survival in experimental sepsis by down-regulating TLR4 signaling pathway

Wei, Zhimin; Wang, Zhuo; Wan, Xiaojian; Li, Xian-Jing; Li, Yixing; Bai, Yang; Yang, Xue; Yang, Yong; Jiao, Shunchang; Liu, Zhefeng

doi:10.1007/s12026-018-9039-y

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Biomarkers Of Sepsis1

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2019

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“…FcγR1/CD64 expression on neutrophils is also reported to be associated with the severity of SIRS and sepsis. The deletion of FcγR1 improves survival in septic mice by downregulating the TLR4 signaling pathway [125]. To investigate the clinical diagnosis value of CD64 expression in ill adult sepsis patients, 1986 patients were enrolled with the meta-analysis.…”

Section: Biomarkers Of Sepsismentioning

confidence: 99%

The Pathogenesis of Sepsis and Potential Therapeutic Targets

Huang

Cai

2019

IJMS

462

332

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Sepsis is defined as “a life-threatening organ dysfunction caused by a host’s dysfunctional response to infection”. Although the treatment of sepsis has developed rapidly in the past few years, sepsis incidence and mortality in clinical treatment is still climbing. Moreover, because of the diverse manifestations of sepsis, clinicians continue to face severe challenges in the diagnosis, treatment, and management of patients with sepsis. Here, we review the recent development in our understanding regarding the cellular pathogenesis and the target of clinical diagnosis of sepsis, with the goal of enhancing the current understanding of sepsis. The present state of research on targeted therapeutic drugs is also elaborated upon to provide information for the treatment of sepsis.

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Section: Biomarkers Of Sepsismentioning

confidence: 99%