FcRn regulates antigen presentation in dendritic cells downstream of DEC205-targeted vaccines
Christophe Macri,
Matthew Paxman,
Devi Jenika
et al.
Abstract:Dendritic cell (DC)-targeted vaccination is a new mode of antigen delivery that relies on the use of monoclonal antibodies (mAb) to target antigen to specific DC subsets. The neonatal Fc receptor (FcRn) is a non-classical Fc receptor that binds to immunoglobulin G (IgG) in acidified endosomes and controls its intracellular transport and recycling. FcRn is known to participate in the antigen presentation of immune complexes, however its contribution to DC-targeted vaccination has not previously been examined. H… Show more
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