FCRL3 gene polymorphisms confer risk for sudden sensorineural hearing loss in a Chinese Han Population

Liu, Hong; Gu, Zheng; Kang, Hou‐Yong; Xia, Ke; Shen, Yang; Wang, Xiaoqiang; Hu, Guohua; Zeng, Jihong; Hong, Suling

doi:10.1016/j.gene.2015.06.005

Cited by 6 publications

(6 citation statements)

References 28 publications

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“…Increased risk was determined by a significantly higher SNP frequency observed in affected SSNHL subjects compared to controls. In contrast, the following seven genes had at least one SNP correlated with a decreased risk: APOE , DNMT1 , FCRL3 , GRHL2 , GPX3, HSPA1A , SERPINE1 (23–29) (Supplemental Digital Content, Table 1, http://links.lww.com/MAO/B337). Decreased risk was inferred by the observation of a significantly lower SNP frequency in SSNHL subjects compared to controls, or by a significantly higher SNP frequency in controls compared to SSNHL subjects.…”

Section: Resultsmentioning

confidence: 99%

“…Decreased risk was inferred by the observation of a significantly lower SNP frequency in SSNHL subjects compared to controls, or by a significantly higher SNP frequency in controls compared to SSNHL subjects. Interestingly, there were two genes, DNMT1 and FCRL3, for which specific genotypes in different SNPs of each gene were found to have opposite associations with SSNHL risk (23,25).…”

Section: Gene Target Association With Ssnhl Susceptibilitymentioning

confidence: 99%

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Utilizing Single Cell RNA-Sequencing to Implicate Cell Types and Therapeutic Targets for SSNHL in the Adult Cochlea

Nelson

Johns

et al. 2021

Otology &Amp; Neurotology

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Section: Resultsmentioning

confidence: 99%

Section: Gene Target Association With Ssnhl Susceptibilitymentioning

confidence: 99%

Utilizing Single Cell RNA-Sequencing to Implicate Cell Types and Therapeutic Targets for SSNHL in the Adult Cochlea

Nelson

Johns

et al. 2021

Otology &Amp; Neurotology

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“…FCRL3 is an immunoglobulin receptor and has specific immunoreceptor-tyrosine activation/inhibitor motifs in its cytoplasmic domain, affecting the modulation of the immune response. 15 Genetic variation in FCRL3 has been associated with a wide range of diseases in different samples, including allergic rhinitis, 16 sudden sensorineural hearing loss, 17 autoimmune thyroid disease, 18 rheumatoid arthritis, 19 and multiple sclerosis. 20 rs11264799 and rs7528684 in FCRL3 have been investigated in many association studies, and a meta-analysis has verified a significant association between these two SNPs and human autoimmune diseases.…”

Section: Discussionmentioning

confidence: 99%

Genetic Polymorphisms of FCRL3, NLRP3 and IL2 are Associated with the Risk of Head and Neck Cancer in a Chinese Population

Zhang

Sun

2021

PGPM

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Purpose This study aimed to evaluate the associations between immune-related gene ( FCRL3, NLRP3 and IL2 ) polymorphisms and the risk of head and neck cancer (HNC). Methods Six polymorphisms of FCRL3, NLRP3 and IL2 were genotyped in 400 HNC cases and 400 controls using a MassARRAY platform. Results rs11264799-T was a protective variant against HNC risk, while rs7528684-G, rs35829419-A and rs6822844-T were all risk alleles for HNC ( p < 0.05). rs11264799-TT was correlated with reduced HNC risk, while rs7528684-GG and rs6822844-TG were associated with an elevated risk of disease ( p < 0.05). Moreover, rs11264799 was correlated with a declining risk of HNC in three genetic models ( p < 0.05). In contrast, rs7528684 exhibited an elevated risk of HNC in recessive and additive models; rs35829419 and rs6822844 were associated with an increased risk of disease in dominant and additive models ( p < 0.05). Finally, an interaction was observed between the above SNPs and drinking ( p < 0.05). Conclusion The results expand our knowledge on immune-related gene polymorphisms in HNC and provide clues for further functional study on the pathogenesis of HNC.

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“…FCRL3, which is a member of immunoglobulin receptor family, is a crucial genetic autoimmunity factor that functions as the mediator between the innate and adaptive immune systems. Considering autoimmunity is one of the important etiologies of SSNHL, Liu et al [2015] evaluated 5 SNPs of FCRL3 in SSNHL patients and revealed a remarkable correlation between three SNPs (rs3761959, rs7522061, rs7528684) and SSNHL among Chinese Han population.…”

Section: Fcrl3 Genementioning

confidence: 99%

Genetic Polymorphisms and Susceptibility to Sudden Sensorineural Hearing Loss: A Systematic Review

et al. 2019

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Background: Recently, genetic factors have been considered as an important risk factor for sudden sensorineural hearing loss (SSNHL). Many studies analyzed the association between SSNHL and polymorphisms. However, most of them gave inconclusive results. Key Message: We performed a systematic review to find out the association between polymorphisms and susceptibility to SSNHL. Finally, 47 studies involving 5,230 SSNHL patients and 68 genes were included for analysis and discussion of results. Polymorphisms in 26 genes have been suggested to be correlated with the susceptibility to SSNHL. Summary: Although a great number of studies support that polymorphisms in genes are associated with susceptibility to SSNHL, we need large multicenter studies, which evaluate multiple single nucleotide polymorphisms in SSNHL patients, to find real genetic risk factors for susceptibility to SSNHL. This is very helpful in designing more effective prevention and treatment strategies for patients with SSNHL.

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FCRL3 gene polymorphisms confer risk for sudden sensorineural hearing loss in a Chinese Han Population

Cited by 6 publications

References 28 publications

Utilizing Single Cell RNA-Sequencing to Implicate Cell Types and Therapeutic Targets for SSNHL in the Adult Cochlea

Utilizing Single Cell RNA-Sequencing to Implicate Cell Types and Therapeutic Targets for SSNHL in the Adult Cochlea

Genetic Polymorphisms of FCRL3, NLRP3 and IL2 are Associated with the Risk of Head and Neck Cancer in a Chinese Population

Genetic Polymorphisms and Susceptibility to Sudden Sensorineural Hearing Loss: A Systematic Review

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