Fcgamma RIIa polymorphism in systemic lupus erythematosus

Abstract

Objectives-Polymorphism of the phagocyte IgG receptor Fc RIIa may modulate immune complex mediated inflammation, particularly when immune complexes contain IgG2. Previous studies suggest that this polymorphism may be an important risk factor for lupus nephritis. Fc RIIa is biallelic, the alleles R and H each having a gene frequency of about 50%. Nephritis has been associated with an increased frequency of the R allele. The frequency of common Fc RIIa alleles was examined in white subjects from the United Kingdom and Greek subjects with systemic lupus erythematosus (SLE) and healthy controls. Methods-Fc RIIa genotyping was performed using a single step polymerase chain reaction technique, which diVerentiates the two major alleles, R and H. Two study populations were examined: (a) white subjects from the United Kingdom : 66 controls and 81 with SLE (19 of whom had renal disease) and (b) Greek: 52 controls and 42 with SLE (19 with renal disease). Results-No significant relation was observed between Fc RIIa genotype and susceptibility to SLE or SLE nephritis. Conclusions-The Fc RIIa R allele does not seem to be associated with SLE (with or without renal disease) in our United Kingdom white or Greek populations.

The genetics of systemic lupus erythematosus: putting the pieces together

“…Other studies, however, did not find an association within their respective European populations. [78][79][80] These differences may be attributable to genetic variances among different ethnic groups. Fc␥RIIA does appear to play an important role in some SLE populations, while playing a smaller (maybe even undetectable) role in others.…”

Association of Fcγ receptor IIIB, but not of Fcγ receptor IIA and IIIA, polymorphisms with systemic lupus erythematosus in Japanese

“…13 Based on the presence of functionally relevant polymorphisms, Fc␥Rs have been considered as attractive candidates for the susceptibility genes to systemic lupus 15,16 while no association was found in AfroCaribbean, Chinese, British and Greek Caucasians. 17,18 The latter studies may lack the statistical power and the results could represent false negatives. A recent study reported that Fc␥RIIA-131H/R polymorphism was associated with clinical symptoms, rather than the development, of SLE.…”

FcγRIIa Polymorphism in Systemic Lupus erythematosus

“…There have been at least four such studies [7,8,10,11] although in one of them [10], FcγRIIa-R131/R131 allotype was significantly associated with some clinical and serological parameters of the disease despite the absence of any influence on the risk for SLE in general. The role of FcγRIIa polymorphism in SLE is clearly uncertain, particularly on the basis of data reported for Caucasian and black patients.…”

“…The failure to demonstrate any association between FcγRIIa allotypes and SLE with or without nephritis has now been reported in several Caucasian [7,8,10], AfroCaribbean [7], Chinese [7,11], and Malay [11] ethnic groups (table 3). Botto et al [7] studied 215 Caucasoid, 70 Afro-Caribbean, and 46 Chinese patients with SLE and 259, 77, and 49 ethnically matched controls, respectively.…”

“…A similar study by Salmon et al [6] but involving only American Caucasians (262 SLE patients and 103 non-SLE controls), failed to replicate the findings of Duits et al [5] that FcγRIIa allotypes are a risk factor with pathophysiologic importance for development of lupus nephritis in Caucasian SLE patients. [12] et al [5] et al [6] et al [7] et al [7] et al [7] et al [8] et al [8] et al [9] et al [10] et al [11] The potential association of FcγRIIa allotypes with SLE in other racial groups was extended to include patients of Korean origin in a study by Song et al [9]. In this study from South Korea, there were 73 SLE patients and 64 non-SLE controls.…”