Fc-saxatilin inhibits VEGF-induced permeability by regulating claudin-5 expression in human brain microvascular endothelial cells

Choi, Hyun Jung; Kim, Na Eun; Kwon, Il; Choi, Dukhwan; Kim, Jayoung; Heo, Ji Hoe

doi:10.1016/j.mvr.2019.103953

Cited by 9 publications

(2 citation statements)

References 28 publications

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“…The use of selective integrin α -β3 inhibitors after stroke may reduce BBB rupture of focal ischemia by inhibiting VEGF-mediated vascular rupture [ 47 - 49 ]. Fc-saxatilin can reduce VEGF-induced permeability in human microvascular endothelial cells (HBMECs) by regulating the activation of Src and Fak signaling proteins in downstream signaling pathways, which may contribute to its protective effect on ischemic cerebrovascular leakage [ 50 ].…”

Section: Therapeutic Studies Targeting Vegfmentioning

confidence: 99%

VEGF, a Key Factor for Blood Brain Barrier Injury After Cerebral Ischemic Stroke

Zheng

Wang

et al. 2022

Aging and disease

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Blood brain barrier (BBB) injury is an important factor affecting the prognosis of ischemic stroke. Extensive research on BBB injury has revealed that blood vessels and neural networks are interdependent and interrelated during and after the development of the brain. An array of signaling molecules, known as angioneurins, can affect both blood vessels and neural networks simultaneously. Angioneurins not only regulate the angiogenesis and remodeling process of the vascular system, but also act as neurotrophic and neuroprotective factors, or serve as guide molecules for axons. Vascular endothelial growth factor (VEGF) is a type of angioneurin that is expressed in neurons, astrocytes, macrophages, and vascular endothelial cells in ischemic and hypoxic brain tissues after cerebral ischemia. VEGF can increase and induce the destruction of the endothelial barrier in the early stages of cerebral ischemia. Both the upregulation of endogenous VEGF levels and the use of exogenous VEGF are harmful in the acute stage of stroke. However, the harmful effects of VEGF on vascular integrity are transient. Several studies have shown that VEGF regulates angiogenesis, neurogenesis, neurite growth and brain edema after cerebral ischemia. Therefore, it is crucial to understand the dual role of VEGF in ischemic stroke. The following will focus on the damage caused by VEGF to the BBB in the context of cerebral ischemic stroke, as well as therapeutic studies targeting VEGF.

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Section: Therapeutic Studies Targeting Vegfmentioning

confidence: 99%

VEGF, a Key Factor for Blood Brain Barrier Injury After Cerebral Ischemic Stroke

Zheng

Wang

et al. 2022

Aging and disease

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“…Claudin-5 is a tight junction protein and an important structural element of the BBB mediating the selective BBB permeability. In claudin-5 knockout mice, the BBB is opened [ 104 ]. In human brain endothelial cells, the expression of this protein is dynamically regulated by VEGF at the transcriptional level.…”

Section: In Vitro Studies Of the Msc Transmigration Through The Bbbmentioning

confidence: 99%

Cell Therapy of Stroke: Do the Intra-Arterially Transplanted Mesenchymal Stem Cells Cross the Blood–Brain Barrier?

Yarygin

Namestnikova

Sukhinich

et al. 2021

Cells

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Animal model studies and first clinical trials have demonstrated the safety and efficacy of the mesenchymal stem cells’ (MSCs) transplantation in stroke. Intra-arterial (IA) administration looks especially promising, since it provides targeted cell delivery to the ischemic brain, is highly effective, and can be safe as long as the infusion is conducted appropriately. However, wider clinical application of the IA MSCs transplantation will only be possible after a better understanding of the mechanism of their therapeutic action is achieved. On the way to achieve this goal, the study of transplanted cells’ fate and their interactions with the blood–brain barrier (BBB) structures could be one of the key factors. In this review, we analyze the available data concerning one of the most important aspects of the transplanted MSCs’ action—the ability of cells to cross the blood–brain barrier (BBB) in vitro and in vivo after IA administration into animals with experimental stroke. The collected data show that some of the transplanted MSCs temporarily attach to the walls of the cerebral vessels and then return to the bloodstream or penetrate the BBB and either undergo homing in the perivascular space or penetrate deeper into the parenchyma. Transmigration across the BBB is not necessary for the induction of therapeutic effects, which can be incited through a paracrine mechanism even by cells located inside the blood vessels.

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Mechanical Behaviour and Finite Element Analysis of Biomaterials: A Review

Sharma

Kukshal

2021

Lecture Notes in Mechanical Engineering

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Fc-saxatilin inhibits VEGF-induced permeability by regulating claudin-5 expression in human brain microvascular endothelial cells

Cited by 9 publications

References 28 publications

VEGF, a Key Factor for Blood Brain Barrier Injury After Cerebral Ischemic Stroke

VEGF, a Key Factor for Blood Brain Barrier Injury After Cerebral Ischemic Stroke

Cell Therapy of Stroke: Do the Intra-Arterially Transplanted Mesenchymal Stem Cells Cross the Blood–Brain Barrier?

Mechanical Behaviour and Finite Element Analysis of Biomaterials: A Review

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