Fc<i>γ</i> receptor polymorphisms and their association with periodontal disease: a meta‐analysis

Dimou, Niki; Nikolopoulos, Georgios K.; Hamodrakas, Stavros J.; Bagos, Pantelis G.

doi:10.1111/j.1600-051x.2009.01530.x

Cited by 42 publications

(35 citation statements)

References 90 publications

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“…The association of Fc-g receptor polymorphisms with the susceptibility to aggressive and chronic periodontitis was previously reported. 39,40 The FCGR2A( þ 131) functional polymorphism has a G-A substitution at nucleotide 519 of the messenger, which results in a switch from arginine (R) to histidine (H) at amino acid position 131 in the immunoglobulin-binding domain. The FCGR3B( þ 78) variant has a C-A substitution at nucleotide 507, which results in a switch from alanine (A) to aspartic acid (D) at amino acid position 78 of the third exon.…”

Section: Discussionmentioning

confidence: 99%

Gene–gene interaction among cytokine polymorphisms influence susceptibility to aggressive periodontitis

et al. 2011

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Aggressive periodontitis (AgP) is a multifactorial disease. The distinctive aspect of periodontitis is that this disease must deal with a large number of genes interacting with one another and forming complex networks. Thus, it is reasonable to expect that gene-gene interaction may have a crucial role. Therefore, we carried out a pilot case-control study to identify the association of candidate epistatic interactions between genetic risk factors and susceptibility to AgP, by using both conventional parametric analyses and a higher order interactions model, based on the nonparametric Multifactor Dimensionality Reduction algorithm. We analyzed 122 AgP patients and 246 appropriate periodontally healthy individuals, and genotyped 28 polymorphisms, located within 14 candidate genes, chosen among the principal genetic variants pointed out from literature and having a role in inflammation and immunity. Our analyses provided significant evidence for gene-gene interactions in the development of AgP, in particular, present results: (a) indicate a possible role of two new polymorphisms, within SEPS1 and TNFRSF1B genes, in determining host individual susceptibility to AgP; (b) confirm the potential association between of IL-6 and Fc g-receptor polymorphisms and the disease; (c) exclude an essential contribution of IL-1 cluster gene polymorphisms to AgP in our Caucasian-Italian population.

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Section: Discussionmentioning

confidence: 99%

Gene–gene interaction among cytokine polymorphisms influence susceptibility to aggressive periodontitis

et al. 2011

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“…NA2 polymorphism in Fc RIIIb , a neutrophil-specific antibody receptor: aggressive periodontitis (123–124). …”

Section: Neutrophil Defects and Polymorphisms Associated With Aggressmentioning

confidence: 99%

Neutrophils in Periodontal Inflammation

Scott

Krauss²

2011

Frontiers of Oral Biology

201

216

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“…Several studies have been carried out to look for the genotypic frequencies of Fc γ RIIA and Fc γ RIIIB in different diseases such as colorectal cancer, chronic periodontal disease, and systemic lupus erythematous [12, 18, 19]. Kuwano et al determined allelic polymorphisms of Fc γ RIIA and Fc γ RIIIB among 263 unrelated Brazilian subjects, including Amazon Indians, blood donors, and sickle cell disease patients.…”

Section: Discussionmentioning

confidence: 99%

The Fc Receptor Polymorphisms and Expression of Neutrophil Activation Markers in Patients with Sickle Cell Disease from Western India

Kangne

Jijina

Italia³

et al. 2013

BioMed Research International

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Objective. Sickle cell disease has variable clinical manifestations. Activation of neutrophils plays an important role in the initiation and propagation of vaso occlusive crises which can be analysed by determining the expression of neutrophil antigens such as CD16, CD32, and CD62L. The common FcγR polymorphisms (FcγRIIA and FcγRIIIB) are considered to influence clinical presentation. This study focuses on distribution of FcγR polymorphisms and their association with neutrophil activity among the patients from western India. Methods. In this paper 127 sickle cell anemia patients and 58 patients with sickle-β-thalassemia (median age 12 ± 8.58 years) with variable clinical phenotypes along with 175 normals were investigated. FcγRs polymorphisms were analysed by RFLP and AS-PCR. Activation of neutrophils was measured by flow cytometry. Results. The genotypic frequency of the H/R genotype of FcγRIIA and the NA1/NA1 genotype of FcγRIIIB was significantly decreased in patients compared to normals (P-0.0074, P-0.0471, resp.). We found a significant difference in the expression of CD32 and CD62L among the patients as against normals. A significantly higher expression of CD32 was seen in the milder patients with the H/H genotype (P-0.0231), whereas the expression of CD16 was higher in severe patients with the NA2/NA2 genotype (P-0.0312). Conclusion. The two FcγR polymorphisms had significant association with variable phenotypes of sickle cell disease. The expression of CD62L decreased in our patients indicating activation of neutrophils.

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Fcγ receptor polymorphisms and their association with periodontal disease: a meta‐analysis

Cited by 42 publications

References 90 publications

Gene–gene interaction among cytokine polymorphisms influence susceptibility to aggressive periodontitis

Gene–gene interaction among cytokine polymorphisms influence susceptibility to aggressive periodontitis

Neutrophils in Periodontal Inflammation

The Fc Receptor Polymorphisms and Expression of Neutrophil Activation Markers in Patients with Sickle Cell Disease from Western India

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