Favre-Racouchot Syndrome in a 39-Year Old Female following Radiation Therapy

Sutherland, Ashley E.; Green, Peter J.

doi:10.2310/7750.2013.13011

Cited by 5 publications

(5 citation statements)

References 11 publications

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“…Radiation therapy has been also described as a possible predisposing factor . In fact, five cases of postradiation FRD are described in the literature.…”

Section: Resultsmentioning

confidence: 99%

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Favre–Racouchot disease: systematic review and possible therapeutic strategies

Paganelli

Mandel

Kaleci

et al. 2018

Acad Dermatol Venereol

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Favre-Racouchot disease (FRD) is a relatively common dermatosis induced by chronic sun exposure. FRD is clinically and histologically characterized by the presence of both comedones and cysts in the context of an elastotic degeneration of the dermis. Those lesions are mainly located in the face, especially in the malar and periorbital areas. Smoking and radiotherapy seem to play a role in the pathogenesis together with UV exposure. The disease affects predominantly the aged population and seems to be a problem of mainly aesthetic concern. No official guidelines are available for the treatment of FRD; most common therapeutic strategies are represented by topical retinoids and laser treatments. The goal of our review was to identify the principal clinical and epidemiological characteristics of FRD and to analyse all the therapeutic strategies available. We also focused our attention on the follow-up of this particular dermatosis. Our aim was therefore to suggest alternative possible strategies for both the treatment and the follow-up of these patients. Our data support the efficacy of carbon dioxide laser and topical retinoids in the setting of FRD, but we also suggest considering alternative treatments, such as plasma exeresis. We also recommend planning both a short-term and a long-term follow-up visit, as the majority of relapses is observed after 10-12 months.

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“…Radiation therapy has been also described as a possible predisposing factor . In fact, five cases of postradiation FRD are described in the literature.…”

Section: Resultsmentioning

confidence: 99%

“…Radiation therapy has been also described as a possible predisposing factor. 13 In fact, five cases of postradiation FRD are described in the literature. Cysts and comedones developed in the irradiated region, after a variable time following radiotherapy, ranging from 2 weeks 14 up to several years.…”

Section: Epidemiologymentioning

confidence: 99%

Favre–Racouchot disease: systematic review and possible therapeutic strategies

Paganelli

Mandel

Kaleci

et al. 2018

Acad Dermatol Venereol

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“…1 The cause of the disease is still unclear, and patients with this disease often have excessive smoking, prolonged sun exposure, ionizing radiation, harsh environment, and other related factors. 2 , 3 With the high incidence among fishermen, farmers, drivers, and the low incidence in women, the disease may be related to its occupational characteristics. 4 It usually occurs in the temporal, periorbital, neck, back of the hand and other exposure areas, with clinical manifestations of blackhead, cyst and elastic fiber nodules as the main features.…”

Section: Discussionmentioning

confidence: 99%

Nodular Elastoidosis with Cysts and Acne: A Case Report

Jiao,

Niu,

Yang

2023

CCID

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A 53-year-old male presented to the clinic for “bilateral temporal dark yellow plaques with pruritus for 8 years.” The patient had bilateral temporal dark yellow plaques without obvious inducement 8 years ago and did not see doctors at that time. Five years ago, bilateral temporal skin lesions gradually increased and were accompanied by severe itching. On top of them, there were several blackheads and pimples with the size of needle tips up to the size of rice grains. After compression, lipid substances could be excreted and there was a clear odor. The patient sought medical attention at a local hospital, but the diagnosis and medication were unknown, and the symptoms did not improve. In the past month, due to the aggravation of skin lesions and itching that affected sleep, he visited the outpatient clinic of our hospital again. The patient was diagnosed with nodular elastoidosis with cysts and acne and was given 5% peroxybenzoyl gel and 0.1% tretinoin cream for topical use. After 2 weeks, the itching symptoms of the patient were significantly reduced.

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“…Major risk factors for FRD seem to be chronic UV exposure, cigarette smoking and radiation therapy. [2][3][4] Histologically FRD is characterized by significant actinic elastosis and epidermal atrophy. 5 Although FRD is a common condition, there are not many treatment options.…”

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confidence: 99%

“…Both patients had the splicing mutation c.2126 + 1G>A in ATP2C1 ( Fig. 2a), 4 which leads to two aberrant splice pattern variants (Fig. 2b).…”

mentioning

confidence: 99%