Favourable outcome of coronavirus disease 2019 in a 1‐year‐old girl with acute myeloid leukaemia and severe treatment‐induced immunosuppression

Sieni, Elena; Pegoraro, Francesco; Casini, Tommaso; Tondo, Annalisa; Bortone, Barbara; Moriondo, Maria; Azzari, Chiara; Galli, Luisa; Favre, Claudio

doi:10.1111/bjh.16781

Cited by 31 publications

(43 citation statements)

References 7 publications

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“… 3 , 10 A 1-year-old girl with acute myeloid leukemia receiving chemotherapy at the Meyer Children's Hospital in Florence, Italy, developed temperatures and increased bilateral reticular marking on chest X-ray but fortunately fully recovered without needing any airway support. 11 Hrusak et al made a flash survey on COVID-19 incidence and severity among children on anticancer treatment. 12 Reports from 25 countries worldwide, covering a population of approximately 10,000 children and young people on anti-cancer therapy, identified only nine children that tested positive for SARS-CoV-2.…”

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confidence: 99%

COVID‐19 – Impact on Childhood Haematology Patients

et al. 2020

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confidence: 99%

COVID‐19 – Impact on Childhood Haematology Patients

et al. 2020

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“…(12) In an Italian pediatric haemato-oncology clinic, SARS-CoV-2 infection was detected in 4 out 170 patients at the molecular level; three of them were asymptomatic. (13)The clinical course and outcome of SARS-CoV-2 was reported to be more favorable in children than in adults (1) A possible explanation that children might have less severe disease was attributed to the lower expression of ACE2 receptor and present with a different inflammatory response, with higher numbers of B and T regulator cells, involved in immune tolerance and leading to a less inflammatory immune response. (14) The detrimental impact of COVID-19 pandemic on childhood cancer may be delay in diagnosis (15), delay in starting treatment, the detrimental impact of infection on children with cancer, and the uncertainty about decision for chemotherapy in PCR-positive asymptomatic patients.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 in Children with Cancer: A single Low-Middle income center experience

Ebeid

Ragab

Elsherif

et al. 2020

Preprint

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Background: Coronavirus disease-2019 (COVID-19) could be associated with morbidity and mortality in immunocompromised children. Objective: To measure the frequency of SARS-COV-2 infection among hospitalized children with cancer and detect the associated clinical manifestations and outcomes. Methodology: A prospective non-interventional study including all hospitalized children with cancer conducted between mid-April and mid-June 2020 in Ain Shams University hospital, Egypt. Clinical, laboratory and radiological data were collected. SARS-CoV2 infection was diagnosed by RT-PCR tests in nasopharyngeal swabs. Results: Fifteen of 61 hospitalized children with cancer were diagnosed with SARS-COV-2. Their mean age was 8.3±3.5 years. Initially, 10(66.7%) were asymptomatic and 5(33.3%) were symptomatic with fever and/or cough. Baseline laboratory tests other than SARS-COV-2 RT-PCR were not diagnostic; the mean absolute lymphocyte count was 8.7±2.4 x109/L, C-reactive protein was mildly elevated in most of patients. Imaging was performed in 10(66.7%) patients with significant radiological findings detected in 4(40%) patients. Treatment was mainly supportive with antibiotics as per the febrile neutropenia protocol and local Children Hospital guidance for management of COVID-19 in children. Conclusion: Pediatric cancer patients with COVID-19 were mainly asymptomatic or with mild symptoms. A high index of suspicion and regular screening with nasopharyngeal swab in asymptomatic hospitalized cancer patients is recommended. Introduction: Coronavirus disease 2019 (COVID-19) is a viral respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the first case was detected in December 2019. (1) The COVID-19 pandemic has rapidly escalated into a global crisis. (2) The first case registered in Egypt was in February 2020 and since that date, the numbers have been increasing and by mid-June 2020, 47,856 cases of SARS-CoV-2 and 1766 deaths have been reported by the Ministry of Health (3). Children are usually develops mild disease (4), a Chinese analysis of 2135 confirmed or suspected cases of COVID-19 among children revealed that 55.4% developed mild symptoms or were asymptomatic and only 5.4% had severe illness compared with 18.5% of adult cases. (5) Viral infections in general are associated with increased morbidity and mortality in immunocompromised children. (6) Data on the clinical features and outcomes of immunocompromised children with cancer who are infected with SARS-CoV-2 are scarce. Knowledge from previous influenza A H1N1 pandemics suggests that those vulnerable immunosuppressed children are likely to be infected and to develop manifestation as an increased number of cases are described with time. (7,8) Although isolation as an inpatient is common practice for children who are receiving intensive chemotherapy or stem cell transplant, most children with cancer are treated in the outpatient setting, and hospital visits

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“…Em geral, as crianças são menos hospitalizadas que os adultos (Concha, Rodríguez, Paredes, & Landeros, 2020;Sieni et al, 2020), mesmo aquelas que apresentam alguma doença subjacente (De Luca et al, 2020). Em um dos estudos analisados, a taxa de hospitalização foi semelhante entre crianças com comorbidades e aquelas sem comorbidade, Research, Society and Development, v. 9, n. 12, e5391210748, 2020 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v9i12.…”

Section: Discussionunclassified

A COVID-19 e as crianças com doenças crônicas: revisão de escopo

Antunes

Kinalski

Schneider

et al. 2020

RSD

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Diante do cenário da pandemia por coronavírus, que assola o mundo desde o final de 2019, ainda são muitas as incertezas que envolvem essa doença, COVID-19, e o público pediátrico, principalmente as crianças portadoras de doenças crônicas. Considerando essa realidade, o objetivo deste artigo é conhecer as publicações científicas sobre COVID-19 em crianças com doenças crônicas. Trata-se de um estudo de revisão sistematizada da literatura do tipo Scoping Reviews. A busca foi realizada nos meses de maio de 2020 a agosto de 2020, nas bases eletrônicas de dados SciVerse Scopus, Literatura Latino-Americana e do Caribe em Ciências da Saúde, Public MEDLINE, Current Nursing and Allied Health Literature e Embase, e totalizaram 5.570 produções científicas. A amostra final foi composta por 46 artigos na íntegra, que tiveram os conteúdos extraídos por categorias conceituais: suscetibilidade/fatores de risco; manifestações clínicas; hospitalização; estratégias de cuidado e medidas preventivas em relação à COVID-19 em crianças com doenças crônicas. A pesquisa permite concluir que crianças com doenças crônicas representam um grupo da população que pode apresentar um risco aumentado para complicações da COVID-19. Contudo, os estudos analisados demonstram que não há motivos para suspender o tratamento de crianças com doenças crônicas durante a pandemia e que é fundamental avaliar o risco versus o benefício de iniciar ou manter o tratamento em casos de crianças confirmadas para COVID-19.

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Favourable outcome of coronavirus disease 2019 in a 1‐year‐old girl with acute myeloid leukaemia and severe treatment‐induced immunosuppression

Cited by 31 publications

References 7 publications

COVID‐19 – Impact on Childhood Haematology Patients

COVID‐19 – Impact on Childhood Haematology Patients

COVID-19 in Children with Cancer: A single Low-Middle income center experience

A COVID-19 e as crianças com doenças crônicas: revisão de escopo

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