Favourable hypotensive effect after standardised tomato extract treatment in hypertensive subjects at high cardiovascular risk: a randomised controlled trial

Krasińska, Beata; Osińska, Angelika; Krasińska, Aleksandra; Osiński, Maciej; Rzymski, Piotr; Tykarski, Andrzej; Krasiński, Zbigniew

doi:10.5603/kp.a2017.0215

Cited by 12 publications

(10 citation statements)

References 21 publications

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“…However, in our previous study, we have not found any reduction in blood pressure following a 4-week treatment with ASA compared with standardized tomato extract (213 mg/ day). Both drugs were administered in the morning, and the treatment group included patients of high and very high cardiovascular risk [40]. Similar results were published by Avazini et al who did not observe a decrease in SBP and DBP in patients treated for hypertension with a low-dose ASA administered in the morning [19].…”

Section: Discussionsupporting

confidence: 58%

The impact of acetylsalicylic acid dosed at bedtime on circadian rhythms of blood pressure in the high-risk group of cardiovascular patients—a randomized, controlled trial

Krasińska

Paluszkiewicz

Miciak-Ławicka

et al. 2020

Eur J Clin Pharmacol

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Purpose Time of drug administration may significantly influence its effect. The aim of the present study was to investigate the effect of ASA (administrated in the morning or in the evening) on the anti-hypertensive effect and diurnal blood pressure profile in the high-risk group of cardiovascular patients. Methods All patients (n = 114) had been diagnosed with coronary heart disease and arterial hypertension prior to the enrolment and had been treated with 75 mg per day of ASA in the morning. The patients were randomly assigned to one of the two study groups receiving 75 mg of ASA per day in a single antiplatelet therapy for 3 months in the morning (n = 58) or in the evening (n = 56). The control group (n = 61) consisted of patients with arterial hypertension but without coronary heart disease, not receiving ASA. In all the patients, during each visit, clinical blood pressure (BP) and ambulatory blood pressure measurements (ABPM) were performed. Results There was a significant reduction in 24-h BP and blood pressure at night in the ASA group evening group compared with the ASA morning group and the control group. Conclusions The present study demonstrated that compared with the use of ASA in the morning, its administration in the evening may lead to favourable drop in the ABPM and an improvement of the diurnal profile in the high-risk group of cardiovascular patients who are not naïve to ASA.

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Section: Discussionsupporting

confidence: 58%

The impact of acetylsalicylic acid dosed at bedtime on circadian rhythms of blood pressure in the high-risk group of cardiovascular patients—a randomized, controlled trial

Krasińska

Paluszkiewicz

Miciak-Ławicka

et al. 2020

Eur J Clin Pharmacol

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“…Recently, an antiplatelet effect of tomato extract, mostly attributed to the presence of phenolic compounds, has been well documented in in vitro experimental studies. Its partial benefits in the primary prevention of CVD have been reported for obese subjects [11,12]. A growing interest has also been expressed in the use of mushrooms as functional foods [13,14], and, in recent decades, certain mushroom species have been experimentally found to exert antiplatelet effects through different pathways.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Mushroom Extracts on Human Platelet and Blood Coagulation: In vitro Screening of Eight Edible Species

et al. 2019

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Cardiovascular diseases remain the leading global cause of mortality indicating the need to identify all possible factors reducing primary and secondary risk. This study screened the in vitro antiplatelet and anticoagulant activities of hot water extracts of eight edible mushroom species (Agaricus bisporus, Auricularia auricularia-judae, Coprinus comatus, Ganoderma lucidum, Hericium erinaceus, Lentinula edodes, Pleurotus eryngii, and Pleurotus ostreatus) increasingly cultivated for human consumption, and compared them to those evoked by acetylsalicylic acid (ASA). The antioxidant capacity and concentration of polysaccharides, phenolic compounds, organic acids, ergosterol, macro elements, and trace elements were also characterized. The most promising antiplatelet effect was exhibited by A. auricularia-judae and P. eryngii extracts as demonstrated by the highest rate of inhibition of adenosine-5′-diphosphate (ADP)-induced and arachidonic acid (AA)-induced aggregation. The response to both extracts exceeded the one evoked by 140 µmol/L of ASA in the ADP test and was comparable to it in the case of the AA test. Such a dual effect was also observed for G. lucidum extract, even though it was proven to be cytotoxic in platelets and leukocytes. The extract of P. ostreatus revealed an additive effect on AA-induced platelet aggregation. None of the mushroom extracts altered the monitored coagulation parameters (prothrombin time, prothrombin ratio, and International Normalized Ratio). The effect of mushroom extracts on platelet function was positively related to their antioxidative properties and concentration of polysaccharides and ergosterol, and inversely related to zinc concentration. The study suggests that selected mushrooms may exert favorable antiplatelet effects, highlighting the need for further experimental and clinical research in this regard.

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“…Typical antiplatelet drugs have an irreversible mechanism of action (44,45). Similarly, ZAAX standardized tomato extract (Sequia) has also been found to possess antiaggregatory properties in high-risk hypertension patients: a study on a group of 82 patients aged 28-74 y who may be at high risk of cardiovascular disease found a dose of 213 mg orally in the morning to be effective at preventing aggregation (47), whereas Krasinska et al (48) note a positive correlation between blood platelet activation and P2Y12 receptor activity, particularly in obese patients. Some studies indicated that the bioactive component of tomatoes is lycopene, known to have antioxidant, antihypertensive, and hypolipidemic effects in vitro and in vivo (70,71).…”

Section: Tomato (Solanum Lycopersicum L)mentioning

confidence: 99%

“…Some studies indicated that the bioactive component of tomatoes is lycopene, known to have antioxidant, antihypertensive, and hypolipidemic effects in vitro and in vivo (70,71). In addition, although Thies et al (72) reported that lycopene may also have an effect on blood platelet activation, none of the studies of Fruitflow or ZAAX tomato extract described the concentration of lycopene in the preparations (44,45,47,48,46).…”

Section: Tomato (Solanum Lycopersicum L)mentioning

confidence: 99%

Anti-Aggregatory Potential of Selected Vegetables—Promising Dietary Components for the Prevention and Treatment of Cardiovascular Disease

Olas

2019

Advances in Nutrition

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Increased blood platelet activation, especially platelet aggregation, plays an important function in cardiovascular disease; however, various dietary components may inhibit platelet activation. Recent clinical and epidemiologic studies indicate that both fruits and vegetables, and their products, contain various phytoprotective substances possessing biological properties such as antiplatelet and antioxidant effects that may work synergistically to ameliorate the effect of cardiovascular disease. In addition, the consumption of vegetables and their products may also play an important role in prevention. However, the mechanisms involved have not been clearly defined. Various studies clearly indicate that certain vegetables (e.g., onions, garlic, and tomatoes) have beneficial effects on blood platelet hyperactivity, an important cardiovascular risk factor, and hence may offer new prophylactic and therapeutic possibilities for the treatment of blood platelet hyperactivation and cardiovascular disease. This mini-review evaluates the current literature on the relationship between the consumption of onion (Allium cepa L.), garlic (Allium sativum L.), tomato (Solanum lycopersicum L.), and beetroot (Beta vulgaris L.), and blood platelet activation, which may have important implications for the prophylaxis and treatment of cardiovascular disease.

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Favourable hypotensive effect after standardised tomato extract treatment in hypertensive subjects at high cardiovascular risk: a randomised controlled trial

Cited by 12 publications

References 21 publications

The impact of acetylsalicylic acid dosed at bedtime on circadian rhythms of blood pressure in the high-risk group of cardiovascular patients—a randomized, controlled trial

The impact of acetylsalicylic acid dosed at bedtime on circadian rhythms of blood pressure in the high-risk group of cardiovascular patients—a randomized, controlled trial

The Effect of Mushroom Extracts on Human Platelet and Blood Coagulation: In vitro Screening of Eight Edible Species

Anti-Aggregatory Potential of Selected Vegetables—Promising Dietary Components for the Prevention and Treatment of Cardiovascular Disease

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