Favourable effect of flunarizine on the recovery from hemiparesis in rats with intracerebral hematomas

Treatment of intracerebral hemorrhage in animal models: Meta‐analysis

“…The most frequently used animal model of ICH was collagenase injection (53 [60%] studies; see Supporting Information Table 1), and ICH was induced in the striatum in all but 1 study (99%) 51. The median number of treated or control animals used in each study was 14 (interquartile range, 12–21; full range, 6–100).…”

“…We excluded 10 studies because ICH was not induced using collagenase or autologous blood injection,16–18 outcome data could not be extracted or obtained,19 variance values of zero precluded meta‐analysis,20, 21 or interventions were administered before the induction of ICH22–25 (although we included 3 of these studies in a post hoc sensitivity analysis24–26). After corresponding authors clarified the data in 2 studies,27, 28 we included 88 studies reporting 151 different treatment comparisons (87 of which had sham groups) that described the effects of nonsurgical interventions on neurobehavioral outcome in 2,616 treated or control rodents with ICH (Supporting Information Table 1) 26–113…”