Favourable effect of an acidified milk (LC-1) on Helicobacter pylori gastritis in man

Felley, Christian; Corthésy–Theulaz, Irène; Rivero, Jose-Luis Blanco; Sipponen, P; Kaufmann, Martin; Bauerfeind, Peter; Wiesel, Paul; Brassart, Dominique; Pfeifer, Andréa; Blum, A. L.; Michetti, Pierre

doi:10.1097/00042737-200101000-00005

Cited by 179 publications

(103 citation statements)

References 28 publications

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“…Clarithromycin eradicated H. pylori in 26% of the subjects and LC-1 did not improve the effect of the antibiotic. 46 Side effects decreased during supplementation with L. casei DG in the course of quadruple therapy, resulting in a slight improvement of H. pylori eradication. 47 The results of these studies suggest that probiotic supplementation during anti-H. pylori therapy decreases adverse side effects, resulting in better compliance and, in some cases, improved rates of eradication.…”

Section: Utilization Of Probiotics In Association With Antibiotics Inmentioning

confidence: 99%

Systematic review: are probiotics useful in controlling gastric colonization by Helicobacter pylori?

Gotteland

Brunser

Cruchet

2006

Aliment Pharmacol Ther

217

161

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SUMMARYHelicobacter pylori is a highly prevalent pathogen considered as an aetiological factor for gastroduodenal ulcers, and a risk factor for gastric adenocarcinoma and lymphoma in humans. Most subjects colonized by this micro-organism are asymptomatic and remain untreated. In symptomatic patients, the antibiotic treatment has a high cost and is not 100% effective because of resistance to antibiotics and to moderate patient compliance. This review discusses the role of probiotics as alternative solutions to assist in the control of H. pylori colonization in atrisk populations.The evidence that some strains of Lactobacillus and Bifidobacterium are able to inhibit H. pylori growth through the release of bacteriocins or organic acids, and may also decrease its adhesion to epithelial cells, is reviewed. In addition, probiotics have a possible role in the stabilization of the gastric barrier function and the decrease of mucosal inflammation. Other aspects that are considered are the contribution of probiotics to the healing of the gastric mucosa linked to their antioxidant and anti-inflammatory properties.Clinical trials in colonized adults and children are reviewed, and suggest that probiotics do not eradicate H. pylori but maintain lower levels of this pathogen in the stomach; in combination with antibiotics, probiotics may increase eradication rate and/or decrease adverse effects. Papers suggesting similar effects on H. pylori by foodstuffs such as berry juice and some milk proteins are quoted. Regular intake of these and other dietary products might constitute a low-cost, large-scale alternative solution applicable for populations at-risk for H. pylori colonization.

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Section: Utilization Of Probiotics In Association With Antibiotics Inmentioning

confidence: 99%

Systematic review: are probiotics useful in controlling gastric colonization by Helicobacter pylori?

Gotteland

Brunser

Cruchet

2006

Aliment Pharmacol Ther

217

161

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“…L. johnsonii La1 (formerly Lactobacillus acidophilus La1) is a Nestlé proprietary strain that has been extensively studied for its probiotic properties and is commercialised in the LC 1 fermented milk products. La1 shows immunomodulatory properties (Link-Amster et al 1994;Schiffrin et al 1995;Haller et al 2000a,b), antipathogenic properties (Bernet et al 1994;BernetCamard et al 1997;Felley et al 2001;Pérez et al 2001) and the ability to interact with the host (Granato et al 1999;Neeser et al 2000). The determination and analysis of the complete genome sequence of L. johnsonii La1 has provided valuable targets for the investigation of the above interactions.…”

Section: Lactobacillus Johnsonii La1 (Ncc2761) (Contributed By David mentioning

confidence: 99%

Discovering lactic acid bacteria by genomics

Klaenhammer

Altermann

Arigoni

et al. 2002

Lactic Acid Bacteria: Genetics, Metabolism and Applications

132

145

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This review summarizes a collection of lactic acid bacteria that are now undergoing genomic sequencing and analysis. Summaries are presented on twenty different species, with each overview discussing the organisms fundamental and practical significance, environmental habitat, and its role in fermentation, bioprocessing, or probiotics. For those projects where genome sequence data were available by March 2002, summaries include 30 a listing of key statistics and interesting genomic features. These efforts will revolutionize our molecular view of Gram-positive bacteria, as up to 15 genomes from the low GC content lactic acid bacteria are expected to be available in the public domain by the end of 2003. Our collective view of the lactic acid bacteria will be fundamentally changed as we rediscover the relationships and capabilities of these organisms through genomics.

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“…[29]. Further investigations in Switzerland have found that L. johnsonii probiotics are capable of producing a favourable affect on H.pylori induced gastritis in human subjects including a trial which found that 2 weeks of L. johnsonii consumption suppressed H.pylori infection regardless of whether it was combined with a standard medication used to treat H. pylori called omeprazole, or with a placebo [30].…”

Section: Infectionsmentioning

confidence: 99%

Probiotics and human health: Synoptic review.

Maity¹,

Misra²

2009

African Journal of Food, Agriculture, Nutrition and Development

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Favourable effect of an acidified milk (LC-1) on Helicobacter pylori gastritis in man

Abstract: These results suggest that H. pylori infection and gastritis can be down-regulated by LC-1.

Cited by 179 publications

References 28 publications

Systematic review: are probiotics useful in controlling gastric colonization by Helicobacter pylori?

Systematic review: are probiotics useful in controlling gastric colonization by Helicobacter pylori?

Discovering lactic acid bacteria by genomics

Probiotics and human health: Synoptic review.

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