Favorable outcomes of interferon-α and ribavirin treatment for a male with subacute sclerosing panencephalitis

Sonoda, Yuri; Sonoda, Motoshi; Yonemoto, Kousuke; Sanefuji, Masafumi; Taira, Ryoji; Motomura, Yoshitomo; Ishimura, Masataka; Torisu, Hiroyuki; Kira, Ryutaro; Kusuhara, Koichi; Sakai, Yasunari; Ohga, Shouichi

doi:10.1016/j.jneuroim.2021.577656

Cited by 2 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A case study of a 10-year-old Japanese boy demonstrated that the advancement of SSPE can be avoided by using intraventricular interferon-α. High levels of T helper 17 (TH-17) cells were shown on a flow-cytometric analysis with the use of intraventricular interferon-α [ 48 ]. According to a case report, the combination of ribavirin with Interferon-alpha and Inosiplex proved to be a good treatment option with positive responses [ 49 ].…”

Section: Prevention and Controlmentioning

confidence: 99%

Measles Induced Encephalitis: Recent Interventions to Overcome the Obstacles Encountered in the Management Amidst the COVID-19 Pandemic

et al. 2022

View full text Add to dashboard Cite

Encephalitis, a well-known complication of measles, is inflammation of the brain parenchyma which is mostly due to the viral invasion of neurons. It presents with a variety of symptoms ranging from mild to severe depending on the extent of the damaged neurons. The diagnosis is based on clinical symptoms such as fever, headache, altered level of consciousness, focal neurological deficits, etc. A detailed history and physical examination facilitate the diagnosis. Investigations include blood tests for measles-specific antibodies, CT, MRI, and analysis of the CSF. The management of measles-induced encephalitis mainly revolves around prevention against contracting the disease and providing supportive care if acquired. The administration of the measles vaccine is the major means of preventing this disease in childhood. Two doses are required to achieve sufficient immunity against measles, the first at the age of 12–15 months and the second at 4–6 years of age. Supportive care includes administering acetaminophen for fever, oral rehydrating salt (ORS) for diarrhea and vomiting, antibiotics for otitis media and pneumonia, and using anti-epileptics such as sodium valproate for seizures. Vitamin A can be given to prevent severe effects in children. The specific treatment would depend on the type of encephalitis the patient has developed.

show abstract

Section: Prevention and Controlmentioning

confidence: 99%

Measles Induced Encephalitis: Recent Interventions to Overcome the Obstacles Encountered in the Management Amidst the COVID-19 Pandemic

et al. 2022

View full text Add to dashboard Cite

show abstract

Functional properties of measles virus proteins derived from a subacute sclerosing panencephalitis patient who received repeated remdesivir treatments

Schmitz,

Handrejk,

Liepina

et al. 2024

J Virol

View full text Add to dashboard Cite

Measles virus (MeV) causes acute, systemic disease and remains an important cause of morbidity and mortality in humans. Despite the lack of known entry receptors in the brain, MeV can persistently infect the brain causing the rare but fatal neurological disorder subacute sclerosing panencephalitis (SSPE). SSPE-causing MeVs are characterized by a hypermutated genome and a hyperfusogenic F protein that facilitates the rapid spread of MeV throughout the brain. No treatment against SSPE is available, but the nucleoside analog remdesivir was recently demonstrated to be effective against MeV in vitro . We show that treatment of an SSPE patient with remdesivir led to transient clinical improvement and did not induce viral escape mutants, encouraging the future use of remdesivir in SSPE patients. Functional characterization of the viral proteins sheds light on the shared properties of SSPE-causing MeVs and further contributes to understanding how those viruses cause disease.

show abstract

Favorable outcomes of interferon-α and ribavirin treatment for a male with subacute sclerosing panencephalitis

Cited by 2 publications

References 20 publications

Measles Induced Encephalitis: Recent Interventions to Overcome the Obstacles Encountered in the Management Amidst the COVID-19 Pandemic

Measles Induced Encephalitis: Recent Interventions to Overcome the Obstacles Encountered in the Management Amidst the COVID-19 Pandemic

Functional properties of measles virus proteins derived from a subacute sclerosing panencephalitis patient who received repeated remdesivir treatments

Contact Info

Product

Resources

About