Favorable outcomes among neonates not separated from their symptomatic SARS-CoV-2-infected mothers

Martenot, Antoine; Labbassi, Imad; Delfils-Stern, Amélie; Monroy, O.; Langlet, C.; Pichault-Klein, Valérie; Delagrèverie, Héloïse; Marcillac, Fanny de; Fafi‐Kremer, Samira; Deruelle, Philippe; Kuhn, Pierre

doi:10.1038/s41390-020-01226-3

Cited by 10 publications

(21 citation statements)

References 19 publications

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“…Our results agree with those reported by Martenot et al (2021), who found that participants with COVID-19 who roomed-in had an exclusive breastfeeding rate of 11.5% at the time of discharge at 3 days of life, and 50% at the follow-up visit between the 4th and 8th day of life. Considering our analysis, the potential role of interventions employing electronic technologies and the telephone was intriguing, as a useful additional support for improving breastfeeding outcomes, even during rooming-in.…”

Section: Discussionsupporting

confidence: 93%

“…So far, little evidence exists regarding the safety of rooming-in practices among mothers infected with COVID-19 and their newborn infants, and available data are limited to small, non-case-control studies (Martenot et al, 2021; Ronchi et al, 2021). Herein, we describe our experience with mothers infected with COVID-19 and their newborn infants during the course of the coronavirus pandemic.…”

Section: Introductionmentioning

confidence: 99%

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Rooming-In Practice During the Pandemic: Results From a Retrospective Cohort Study

et al. 2022

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Background: The Coronavirus disease 2019 (COVID-19) pandemic emerged in December 2019 and spread rapidly worldwide. So far, evidence regarding the breastfeeding and rooming-in management of mothers with COVID-19 and their newborn infants is scarce. Research Aims: 1) To assess the rate of exclusive breastfeeding at discharge among mothers with COVID-19 and their newborn infants managed either using a rooming-in or a separation regimen; and 2) to evaluate different neonatal outcomes, including the need for re-hospitalization related to COVID-19 among newborn infants in the two groups. Method: We conducted a retrospective two-group comparative observational study. The sample was participants with COVID-19 and their newborn infants ( N = 155 dyads) between March 1, 2020, and April 30, 2021. Two time periods were outlined resulting from the two different clinical practices of mother–infant separation and rooming-in. Results: Within the sample, 145 (93.5%) were asymptomatic. All neonates had documented Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) test results, and six tested positive by reverse transcriptase polymerase chain reaction within 48 hr of life. The rate of exclusive breastfeeding was significantly higher ( p < .0001) within the rooming-in group. Length of hospital stay was significantly lower ( p = .001) within the rooming-in group. Conclusions: Protected rooming-in practice has proven to be safe and effective in supporting breastfeeding: None of the infants enrolled were hospitalized due to COVID-19 infection and the rate of exclusive breastfeeding at discharge was increased compared to those infants separated from their mothers.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Rooming-In Practice During the Pandemic: Results From a Retrospective Cohort Study

et al. 2022

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“…gegenüber dem Übertragungsrisiko, der Erkrankungswahrscheinlichkeit des Neugeborenen und nicht zuletzt der entstehenden Nachteile bei Trennung von Mutter und Kind abgewogen werden [61,78]. Das Risiko des Neugeborenen, von der Mutter mit SARS-CoV-2 infiziert zu werden, ist gering [79] und das Outcome meist günstig [80]. Das Risiko einer Infektion des Neugeborenen mit SARS-CoV-2 scheint sich nicht in Abhängigkeit davon zu unterscheiden, ob das Neugeborene in einem separaten Raum betreut wird oder im Zimmer der Mutter bleibt [81].…”

Section: Eine Sars-covunclassified

Empfehlungen zu SARS-CoV-2/COVID-19 in Schwangerschaft, Geburt und Wochenbett – Update November 2021 (Kurzfassung)

Zöllkau

Hagenbeck

Hecher

et al. 2022

Z Geburtshilfe Neonatol

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ZusammenfassungSeit Beginn der SARS-CoV-2-Pandemie haben die Deutsche Gesellschaft für Gynäkologie und Geburtshilfe und die Gesellschaft für Peri-/Neonatalmedizin Empfehlungen zum Umgang mit SARS-CoV-2-positiven Schwangerschaften und Neugeborenen veröffentlicht und wiederholt aktualisiert. Als Weiterführung der bestehenden Empfehlungen werden in dem aktuellen Update Schlüsselfragen zur prä-, peri- und postnatalen Versorgung von Schwangeren, Gebärenden, Wöchnerinnen, Stillenden mit SARS-CoV-2 und COVID-19 sowie deren Un- oder Neugeborenen auf der Grundlage von Veröffentlichungen bis zum September 2021 behandelt. Die Empfehlungen und Stellungnahmen wurden sorgfältig aus den aktuell verfügbaren wissenschaftlichen Daten abgeleitet und anschließend im Expertenkonsens verabschiedet. Dieser Leitfaden – hier in der Kurzfassung vorliegend – soll eine Hilfe für die klinische Entscheidungsfindung darstellen. Die Auslegung und therapeutische Verantwortung obliegen weiterhin dem betreuenden medizinischen Team vor Ort, dessen Entscheidungen durch diese Empfehlungen unterstützt werden sollen. Aufgrund der raschen Dynamik neuer Erkenntnisse kann eine Anpassung erforderlich sein. Die Empfehlungen werden durch die Zustimmung der Fachgesellschaften getragen: Deutsche Gesellschaft für Perinatale Medizin (DGPM), Deutsche Gesellschaft für Gynäkologie und Geburtshilfe (DGGG), Deutsche Gesellschaft für Pränatal- und Geburtsmedizin (DGPGM), Deutsche Gesellschaft für Pädiatrische Infektiologie (DGPI), Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin (GNPI).

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“…Most studies examining milk produced by women with coronavirus disease 2019 (COVID-19) have demonstrated that it is an unlikely source of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) maternal-to-child transmission ( 1 – 4 ). Nonetheless, SARS-CoV-2 has been detected in a fraction of milk samples in some studies ( 5 – 7 ).…”

Section: Introductionmentioning

confidence: 99%

Milk From Women Diagnosed With COVID-19 Does Not Contain SARS-CoV-2 RNA but Has Persistent Levels of SARS-CoV-2-Specific IgA Antibodies

et al. 2021

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BackgroundLimited data are available regarding the balance of risks and benefits from human milk and/or breastfeeding during and following maternal infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).ObjectiveTo investigate whether SARS-CoV-2 can be detected in milk and on the breast after maternal coronavirus disease 2019 (COVID-19) diagnosis; and characterize concentrations of milk immunoglobulin (Ig) A specific to the SARS-CoV-2 spike glycoprotein receptor binding domain (RBD) during the 2 months after onset of symptoms or positive diagnostic test.MethodsUsing a longitudinal study design, we collected milk and breast skin swabs one to seven times from 64 lactating women with COVID-19 over a 2-month period, beginning as early as the week of diagnosis. Milk and breast swabs were analyzed for SARS-CoV-2 RNA, and milk was tested for anti-RBD IgA.ResultsSARS-CoV-2 was not detected in any milk sample or on 71% of breast swabs. Twenty-seven out of 29 (93%) breast swabs collected after breast washing tested negative for SARS-CoV-2. Detection of SARS-CoV-2 on the breast was associated with maternal coughing and other household COVID-19. Most (75%; 95% CI, 70-79%; n=316) milk samples contained anti-RBD IgA, and concentrations increased (P=.02) during the first two weeks following onset of COVID-19 symptoms or positive test. Milk-borne anti-RBD IgA persisted for at least two months in 77% of women.ConclusionMilk produced by women with COVID-19 does not contain SARS-CoV-2 and is likely a lasting source of passive immunity via anti-RBD IgA. These results support recommendations encouraging lactating women to continue breastfeeding during and after COVID-19 illness.

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Favorable outcomes among neonates not separated from their symptomatic SARS-CoV-2-infected mothers

Cited by 10 publications

References 19 publications

Rooming-In Practice During the Pandemic: Results From a Retrospective Cohort Study

Rooming-In Practice During the Pandemic: Results From a Retrospective Cohort Study

Empfehlungen zu SARS-CoV-2/COVID-19 in Schwangerschaft, Geburt und Wochenbett – Update November 2021 (Kurzfassung)

Milk From Women Diagnosed With COVID-19 Does Not Contain SARS-CoV-2 RNA but Has Persistent Levels of SARS-CoV-2-Specific IgA Antibodies

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