Favorable outcomes after living-donor lobar lung transplantation in ventilator-dependent patients

Toyooka, Shinichi; Yamane, Masaomi; Oto, Takahiro; Sano, Yoshifumi; Okazaki, Masaharu; Hanazaki, Motohiko; Goto, Keiji; Date, Hiroshi

doi:10.1007/s00595-008-3781-z

Cited by 9 publications

(3 citation statements)

References 18 publications

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“…Strategies to increase the number of suitable lung donors include donor management, non-heart beating donor, livingrelated LuTX and volume reduction surgery of the donor organ to overcome size disparities [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Use of donors who have suffered cardiopulmonary arrest and resuscitation in lung transplantation☆

Pilarczyk

Osswald

Pizanis

et al. 2011

European Journal of Cardio-Thoracic Surgery

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Section: Introductionmentioning

confidence: 99%

Use of donors who have suffered cardiopulmonary arrest and resuscitation in lung transplantation☆

Pilarczyk

Osswald

Pizanis

et al. 2011

European Journal of Cardio-Thoracic Surgery

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“…4,20,23 However, the reason for this discrepancy is unknown. Because the general condition of CLT recipients is better than that of LDLLT recipients, 24,25 according to the policy of LDLLT at our institution donor factors, such as the period of preoperative ventilation, are regarded with special concern, relative to recipient factors. Multiple factors, rather than one single factor, are more likely to infl uence bronchial healing after lung transplantation.…”

Section: Discussionmentioning

confidence: 99%

Bronchial healing after living-donor lobar lung transplantation

et al. 2009

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“…Moreover, all intubated LDLLT candidates were young, ranging in age from 6 to 24 years. In a consensus document for the selection of lung transplant candidates from the ISHLT, although mechanical ventilation and/ or extracorporeal life support have basically been listed as relative contraindications for lung transplantation, mechanical support has been recommended for young patients with good rehabilitation potential (8,9). The primary indications for brain-dead donor and livingdonor lung transplantation in Japan are presented in Figure 3.…”

Section: Inclusion Criteria For Ldllt Recipientmentioning

confidence: 99%

Living-donor lobar lung transplantation

Nakajima¹,

Date²

2021

J Thorac Dis

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Living-donor lobar lung transplantation (LDLLT) has become an important life-saving option for patients with severe respiratory disorders, since it was developed by a group in the University of Southern California in 1993 and introduced in Japan in 1998 in order to address the current severe shortage of brain-dead donor organs. Although LDLLT candidates were basically limited to critically ill patients who would require hospitalization, the long-term use of steroids, and/or mechanical respiratory support prior to transplantation, LDLLT provided good post-transplant outcomes, comparable to braindead donor lung transplantation in the early and late phases. In Kyoto University, the 5-and 10-year survival rates after LDLLT were reported to be 79.0% and 64.6%, respectively. LDLLT should be performed under appropriate circumstances, considering the inherent risk to the living donor. In our transplant program, all living donors returned to their previous social lives without any major complications, and living-donor surgery was associated with a morbidity rate of <15%. Both functional and anatomical size matching were preoperatively performed between the living-donor lobar grafts and recipients. Precise size matching before surgery could provide a favorable pulmonary function and exercise capacity after LDLLT. Various transplant procedures have recently been developed in LDLLT in order to deal with the issue of graft size mismatching in recipients, and favorable post-transplant outcomes have been observed. Native upper lobesparing and/or right-to-left inverted transplantation have been performed for undersized grafts, while singlelobe transplantation has been employed with or without contralateral pneumonectomy and/or delayed chest closure for oversized grafts.

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Favorable outcomes after living-donor lobar lung transplantation in ventilator-dependent patients

Abstract: Our findings suggest that LDLLT can have a favorable outcome in selected ventilator-dependent patients.

Cited by 9 publications

References 18 publications

Use of donors who have suffered cardiopulmonary arrest and resuscitation in lung transplantation☆

Use of donors who have suffered cardiopulmonary arrest and resuscitation in lung transplantation☆

Bronchial healing after living-donor lobar lung transplantation

Living-donor lobar lung transplantation

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