Favorable osteogenic activity of vericiguat doped in β-tricalcium phosphate: In vitro and in vivo studies
Zhou-Shan Tao,
Cai-Liang Shen
Abstract:Recently, more and more studies have shown that guanylate cyclase, an enzyme that synthesizes cyclic guanosine monophosphate (cGMP), plays an important role in bone metabolism. Vericiguat (VIT), a novel oral soluble guanylate cyclase stimulator, directly generates cyclic guanosine monophosphate and reduce the death incidence from cardio-vascular causes or hospitalization. Recent studies have shown beneficial effects of VIT in animal models of osteoporosis, but very little is currently known about the effects o… Show more
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