Favorable influence of local injury to the endometrium in intracytoplasmic sperm injection patients with high-order implantation failure

Raziel, Arieh; Schächter, M; Strassburger, D.; Bern, O.; Ron-El, Raphaël; Friedler, Shevach

doi:10.1016/j.fertnstert.2006.05.062

Cited by 152 publications

(147 citation statements)

References 16 publications

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“…However, those reports varied in terms of the characteristics of the device that was used for injury, the degree of injury, and the timing of the intervention. Various devices have been used to injure the endometrium, such as hysteroscopes and biopsy catheters 1, 3, 4, 5, 6, 7, 9. In this study, an endometrial sampler was used that was considered to be an appropriate tool for inducing a mild endometrial injury.…”

Section: Discussionmentioning

confidence: 99%

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Effects of endometrial injury on frozen‐thawed blastocyst transfer in hormone replacement cycles

Matsumoto

Kokeguchi

Shiotani

2017

Reprod Medicine & Biology

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AimTo evaluate whether local endometrial injury would improve the pregnancy rates after frozen‐thawed blastocyst transfer in cycles with hormone replacement.MethodsSeventy‐seven patients who were aged <40 years with a history of at least three unsuccessful embryo transfers and who underwent frozen‐thawed blastocyst transfer during hormone replacement cycles between February and June, 2013 were studied. They were allocated into two groups based on the last digit of their clinical record number: an experimental group (n=22), excluding patients who withheld consent or who were unable to undergo treatment, and a control group (n=55). In the experimental group, the endometrium was scratched once with an endometrial sampler during the luteal phase of the cycle preceding the embryo transfer.ResultsThere was no significant difference in the baseline characteristics between the groups. The clinical pregnancy rate was 6% in the experimental group and 22% in the control group. Among these, the ongoing pregnancy rate was 100% in the experimental group and 50% in the control group.ConclusionEndometrial injury might increase the pregnancy rates after frozen‐thawed blastocyst transfer and decrease the risk of miscarriage in patients with a history of unsuccessful embryo transfers.

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Section: Discussionmentioning

confidence: 99%

“…One possible cause for this is poor endometrial receptivity. Various approaches to addressing this problem have been explored and some recent studies have shown that local endometrial injury can improve both the implantation rates and pregnancy outcomes in patients with unexplained recurrent implantation failure 1, 2, 3, 4, 5, 6, 7, 8, 9…”

Section: Introductionmentioning

confidence: 99%

Effects of endometrial injury on frozen‐thawed blastocyst transfer in hormone replacement cycles

Matsumoto

Kokeguchi

Shiotani

2017

Reprod Medicine & Biology

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“…Further studies involving direct examination of the endometrium are required in order to establish the mechanism of such an endometrial injury. Stimulation of the endometrium by local injury using an endometrial biopsy catheter was reported to be beneficial to patients with normal endometrial measurements who had otherwise unexplained repeated implantation failures [21,22]. However the patient population in this study differs significantly by having a functionally abnormal endometrium.…”

Section: Discussionmentioning

confidence: 84%

Thin unresponsive endometrium—a possible complication of surgical curettage compromising ART outcome

Shufaro

Simon

Laufer

et al. 2008

J Assist Reprod Genet

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Purpose Endometrial thickness is important for implantation. Little data addresses the etiology of persistently thin endometrium. We present a patient cohort in order to define common features and draw conclusions. Methods Thirteen out of 1,405 IVF patients repeatedly had thin unresponsive endometrium (<7 mm). Age, history, uterine cavity status, treatment type and outcome were examined. Results Patient age was 35.9±5.7 years. Ten patients had a curettage performed previously. Nine patients had normal cavity and endometrium, and in four adhesions were diagnosed and removed. Out of 99 cycles performed afterwards, endometrial thickness increased in 22. ETs were performed in 49 cycles resulting in 11 pregnancies. Their outcome was eight miscarriages, two terminations due to malformations, and one live birth. Conclusions Thin unresponsive endometrium was associated with curettage, not necessarily with intrauterine adhesions. Even if adequate thickening eventually occurred, the reproductive outcome was still very poor. Therefore other alternatives should be sought for these patients.

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“…During normal pregnancy, this inflammation is initiated by the trophoblast and involves the recruitment of natural killer cells to the site of implantation as well as the production of a range of proinflammatory cytokines including IL6 and TNF (57). Localized injury and endometrial biopsies before in vitro fertilization treatment result in greater implantation rates; these increased rates are suspected to be caused by an induction of the proinflammatory molecules necessary for implantation (58,59). Term pregnancy in M. domestica is also inflammatory, with many of the same cytokines (including IL6, TNF, and IL19) being produced in the uterus.…”

Section: Discussionmentioning

confidence: 99%

Embryo implantation evolved from an ancestral inflammatory attachment reaction

Griffith

Chavan

Protopapas

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

176

141

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The molecular changes that support implantation in eutherian mammals are necessary to establish pregnancy. In marsupials, pregnancy is relatively short, and although a placenta does form, it is present for only a few days before parturition. However, morphological changes in the uterus of marsupials at term mimic those that occur during implantation in humans and mice. We investigated the molecular similarity between term pregnancy in the marsupials and implantation in eutherian mammals using the gray short-tailed opossum (Monodelphis domestica) as a model. Transcriptomic analysis shows that term pregnancy in the opossum is characterized by an inflammatory response consistent with implantation in humans and mice. This immune response is temporally correlated with the loss of the eggshell, and we used immunohistochemistry to report that this reaction occurs at the materno-fetal interface. We demonstrate that key markers of implantation, including Heparin binding EGF-like growth factor and Mucin 1, exhibit expression and localization profiles consistent with the pattern observed during implantation in eutherian mammals. Finally, we show that there are transcriptome-wide similarities between the opossum attachment reaction and implantation in rabbits and humans. Our data suggest that the implantation reaction that occurs in eutherians is derived from an attachment reaction in the ancestral therian mammal which, in the opossum, leads directly to parturition. Finally, we argue that the ability to shift from an inflammatory attachment reaction to a noninflammatory period of pregnancy was a key innovation in eutherian mammals that allowed an extended period of intimate placentation.placenta | marsupial | inflammation | pregnancy | evolution I n eutherian (so-called "placental") mammals, pregnancy begins when the blastocyst attaches to the uterine wall, followed by the establishment of a stable fetal-maternal interface. Implantation involves the apposition, attachment, and, in many species, the invasion of the blastocyst into the uterus (1). In particular, structural and molecular changes occur in the luminal epithelia that allow the embryo to attach and invade the uterus (2). Epithelial changes are followed by remodeling of the endometrial stroma, generally known as "decidualization," i.e., the transformation of endometrial stromal fibroblasts into decidual stromal cells, as well as modifications of the endometrial vascular bed (3). When these changes do not occur or occur incompletely, blastocysts fail to implant, resulting in early pregnancy failure (4, 5). In humans, 75% of unsuccessful pregnancies are the result of failures of implantation, and implantation failure is the limiting factor for in vitro fertilization treatment. Furthermore, decades of research have failed to produce clinically effective treatments that increase uterine receptivity to implantation (6-8). Given the magnitude of this problem, extensive efforts have been made to characterize the endometrium for signatures of receptivity (9, 10).Implantati...

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Favorable influence of local injury to the endometrium in intracytoplasmic sperm injection patients with high-order implantation failure

Cited by 152 publications

References 16 publications

Effects of endometrial injury on frozen‐thawed blastocyst transfer in hormone replacement cycles

Effects of endometrial injury on frozen‐thawed blastocyst transfer in hormone replacement cycles

Thin unresponsive endometrium—a possible complication of surgical curettage compromising ART outcome

Embryo implantation evolved from an ancestral inflammatory attachment reaction

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