Favorable Healing Following Space Creation in rhBMP‐2–Induced Periodontal Regeneration of Horizontal Circumferential Defects in Dogs with Experimental Periodontitis

Saito, Emiko; Saito, Akira; Kawanami, Masamitsu

doi:10.1902/jop.2003.74.12.1808

Cited by 39 publications

(41 citation statements)

References 24 publications

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“…The most studied BMPs for bone regeneration applications are BMP-2 and BMP-7 [336,337]. Many preclinical studies have shown the usefulness of recombinant human BMPs for the regeneration of bone tissue [338,339,340,341]. Bone defect healing using genetic approach where an implant comprising of a bioresorbable polymer mixed with mesenchymal stem cells transfected with adenovirus BMP-2 has been demonstrated [342].…”

Section: Developments and The Future Of Bone Augmentationmentioning

confidence: 99%

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Sima²,

2015

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Alveolar bone augmentation in vertical dimension remains the holy grail of periodontal tissue engineering. Successful dental implant placement for restoration of edentulous sites depends on the quality and quantity of alveolar bone available in all spatial dimensions. There are several surgical techniques used alone or in combination with natural or synthetic graft materials to achieve vertical alveolar bone augmentation. While continuously improving surgical techniques combined with the use of auto- or allografts provide the most predictable clinical outcomes, their success often depends on the status of recipient tissues. The morbidity associated with donor sites for auto-grafts makes these techniques less appealing to both patients and clinicians. New developments in material sciences offer a range of synthetic replacements for natural grafts to address the shortcoming of a second surgical site and relatively high resorption rates. This narrative review focuses on existing techniques, natural tissues and synthetic biomaterials commonly used to achieve vertical bone height gain in order to successfully restore edentulous ridges with implant-supported prostheses.

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Section: Developments and The Future Of Bone Augmentationmentioning

confidence: 99%

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Sima²,

2015

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“…On the upper jaw, intraosseous defects on premolars and molars were also described [45, 58, 59]. The number of residual osseous walls present at the level of the surgical defect was considered to be an important factor for healing.…”

Section: The Different Animal Models In Periodontologymentioning

confidence: 99%

Experimental Animal Models in Periodontology: A Review

Struillou¹,

Boutigny²,

Soueidan³

et al. 2010

TODENTJ

181

198

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In periodontal research, animal studies are complementary to in vitro experiments prior to testing new treatments. Animal models should make possible the validation of hypotheses and prove the safety and efficacy of new regenerating approaches using biomaterials, growth factors or stem cells. A review of the literature was carried out by using electronic databases (PubMed, ISI Web of Science). Numerous animal models in different species such as rats, hamsters, rabbits, ferrets, canines and primates have been used for modeling human periodontal diseases and treatments. However, both the anatomy and physiopathology of animals are different from those of humans, making difficult the evaluation of new therapies. Experimental models have been developed in order to reproduce major periodontal diseases (gingivitis, periodontitis), their pathogenesis and to investigate new surgical techniques. The aim of this review is to define the most pertinent animal models for periodontal research depending on the hypothesis and expected results.

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“…Among several growth factors, platelet-derived growth factor (PDGF) (20, 21), fibroblast growth factor-2 (FGF-2) (22, 23), amelogenin (24, 25), and bone morphogenetic proteins (BMPs) (7, 13, 26) are well known to have peri-odontal regeneration potential ( see Table 18.1). …”

Section: Methodsmentioning

confidence: 99%

Preclinical Methods for the Evaluation of Periodontal Regeneration In Vivo

Seol

Pellegrini

Franco

et al. 2010

Methods in Molecular Biology

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For the determination of key factors or devices that promote periodontal regeneration, preclinical investigations using in vivo animal models are critical for evaluating the biological responses before human clinical trial testing. In this chapter, we provide an overview on the commonly used preclinical animals for the study of reconstructive procedures to promote bone and soft tissue repair of tooth-supporting periodontal defects. Steps are provided on the animal management for evaluation of outcome measures using descriptive histology, histomorphometry, three-dimensional imaging, and safety assessments. The use of these key measures of periodontal regeneration should aid investigators in the selection of appropriate surrogate endpoints to be utilized in the clinical arena, which are not practical or ethical in humans. These methods will prepare investigators and assist them in identifying endpoints that can then be adapted to human clinical trial planning.

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Favorable Healing Following Space Creation in rhBMP‐2–Induced Periodontal Regeneration of Horizontal Circumferential Defects in Dogs with Experimental Periodontitis

Abstract: Implantation of rhBMP-2/PGS enhances bone formation and connective tissue attachment in horizontal circumferential defects. In addition, the use of a spacer membrane reduces the degree of bone formation, but minimizes ankylosis.

Cited by 39 publications

References 24 publications

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Experimental Animal Models in Periodontology: A Review

Preclinical Methods for the Evaluation of Periodontal Regeneration In Vivo

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