Favorable Effects of Tea on Reducing the Cognitive Deficits and Brain Morphological Changes in Senescence-Accelerated Mice

Abstract

SummaryThe present study was carried out to explore the effects of oolong and green teas on improving the memory deficits and brain pathological changes in senescence accelerated-prone mice P8 (SAMP8). Six-month-old mice were supplied with oolong tea, green tea or water as the sole drinking fluid for 16 wk. The memory ability of mice was evaluated by passive and active avoidance tests, while the extent of the brain degeneration was measured by the spongiosis grades and the lipofuscin percentage in the hippocampus. The total grading score and serum biochemical levels were also measured. The results indicated that the mice supplemented with the oolong and green tea drinks reversed the cognitive impairment, lessened the spongy degeneration and lipofuscin, and increased the serum Trolox equivalent antioxidant capacity more than the control group. The total grading score of the oolong tea group was lower than that of the control group in male mice, whereas it did not differ among female groups. No differentiations in the concentrations of total cholesterol, triglyceride, glucose, iron or hemoglobin were observed among three drink groups. In conclusion, oolong and green teas could reduce the deteriorations of cognitive ability, brain degenerative changes and aging process in SAMP8, probably through the potent antioxidative activity of the tea.

Moderate-dose Regular Lifelong Alcohol Intake Changes the Intestinal Flora, Protects against Aging, and Keeps Spatial Memory in the Senescence-accelerated Mouse Prone 8 (SAMP8) Model

“…The intake of 1% EtOH had anti-aging effects in SAMP lines. The SAMP lines are often used to evaluate the antiaging effects of anti-oxidant foods such as reduced coenzyme Q10 (57) and teas (58,59). Ethanol is metabolized by alcohol dehydrogenase and aldehyde dehydrogenase, microsomal ethanol oxidation system (MEOS), and catalase.…”

The anti-aging effects of Ludwigia octovalvis on Drosophila melanogaster and SAMP8 mice

“…We further investigated the pro-cognitive effect of LOE in SAMP8 mice, which are known to develop early onset of deficits in learning and memory and have been demonstrated to be a suitable model for studying fundamental mechanisms of Alzheimer's disease Morley 1992, 1993;Chan et al 2006;Takeda 2009). In the novel object recognition tests, 3-monthold SAMP8 mice showed sustained recognition memory up to 3 h after the training session, spending more time on the novel object compared to the familiar object (Fig.…”

The impact of flavonoids on spatial memory in rodents: from behaviour to underlying hippocampal mechanisms

“…Animal studies involving other flavonoid-rich food supplementation such as tea [35] and pomegranate juice [87], or pure flavonols such as quercetin, rutin [159] or fisetin [123] have provided further evidence that dietary flavonoids are beneficial in reversing the course of neuronal and behavioural ageing. For example, the flavanol (-)-epicatechin, especially in combination with exercise, has been observed to enhance the retention, but not the acquisition, of rat spatial memory in water maze tasks [214].…”