Favorable effects of superficially deacetylated chitin nanofibrils on the wound healing process

Abstract

Previous reports indicate that the beneficial effect of chitin nanofibrils (CNFs), and chitosan nanofibrils (CSNFs) for wound healing. In this study, the wound healing effects of superficially deacetylated chitin nanofibrils (SDACNFs) were evaluated using an experimental model. In the experiments using circular excision wound model, SDACNFs induced re-epithelium and proliferation of the fibroblasts and collagen tissue. In the chitin, CNFs, and CSNFs, on the other hand, the e-epithelium and proliferation of the fibroblasts and collagen tissue were not induced perfectly compared with the SDACNFs group. In particular, re-epithelization was observed on day 4 in the only SDACNF group. Moreover, SDACNFs did not induce severe systemic inflammation in the linear incision wound model. The data indicated that SDACNFs effectively induced the proliferation and re-modeling phases compared with chitin, CNFs, and CSNFs in the wound. These data indicate that SDACNFs can be beneficial as a new biomaterial for wound healing.

Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice

“…Owing to cationic electrostatic repulsive forces, the deacetylated chitin readily disintegrated and the SDACNFs were homogeneously dispersed in water. We have reported that SDACNFs have various biological activities, including effects on obesity and hypercholesterolemia by oral administration [14,15] and on wound healing by topical application [16,17]. In this study, we investigated the prophylactic effects of orally administered SDACNFs against 5-FU-induced intestinal mucositis.…”

Effect of purification method of β-chitin from squid pen on the properties of β-chitin nanofibers

“…4 When chitin is disintegrated into NF, the hydrophilic surface area increases, enhancing the biochemical significance of the material [13,14]. As disintegrating methods of chitin into NF, ultrasonication, grinding, or the Star Burst system under acidic conditions have been reported [15][16][17].…”

Protein/CaCO3/Chitin Nanofiber Complex Prepared from Crab Shells by Simple Mechanical Treatment and Its Effect on Plant Growth

“…In a previous study, we isolated chitin nanofibers from crab shells and prepared them using a simple mechanical treatment [2]. Chitin nanofibers have a characteristic morphology [3], high surface-to-volume ratio [4], high mechanical strength [5,6], and efficient biological properties [7,8,9,10]. …”