S ince its original description in 1998, the technique of catheter-based atrial fibrillation (AF) ablation has undergone several modifications. 1 Currently, many operators use an anatomic approach consisting of circumferential lesions encircling individual or ipsilateral pulmonary veins (PVs) with additional empirical left atrial (LA) ablation (lines), whereas others perform a more PV-specific approach using entrance/exit block to validate isolation, deferring any additional non-PV lesions unless clinically indicated. 2-7 Despite these differences in technique, the outcome data for AF patients undergoing ablation seem remarkably consistent between centers, with overall single procedure efficacy of ≥70% in achieving long-term arrhythmia control for patients with paroxysmal AF but significantly lower success rates for patients with persistent or long-standing persistent AF. These observations imply that the mechanisms underlying persistent/long-standing persistent AF may be different from paroxysmal AF. It has been posited that once in the persistent stage, the underlying substrate rather than triggers alone maintains this arrhythmia. Although this hypothesis remains to be proven, it has nevertheless resulted in the development of adjunctive substrate modification strategies for patients with more established forms of AF. 8-11 Among the various substrate modification strategies currently being used, complex fractionated electrogram (CFE) ablation is the most popular. This technique was originally described by Nademanee et al, 8 where by targeting CFEs exclusively these investigators were able to achieve long-term arrhythmia control after a single procedure in up to 70% of patients with persistent AF. However, subsequent attempts by other investigators have not yielded comparable results. 12,13 Despite this inconsistency, many centers are targeting CFEs as a part of the ablation strategy in this group of patients. Contrary to this practice and regardless of the type of AF, our group at the Hospital of the University of Pennsylvania has consistently used an approach comprising pulmonary vein isolation (PVI) with additional targeting of non-PV trigger sites of AF that are identified by a standard stimulation protocol. 14-24 Using this methodology, we have reported outcomes in patients with persistent and long-standing persistent AF, which are comparable with the results achieved by more extensive ablation strategies, including CFE ablation. The purpose of this review is to offer the readers our perspective on the importance of PVs in more established forms of AF and why targeting them (together with documented non-PV trigger sites) remains our preferred ablation strategy for this group of patients.
Response by Roten et al on p 1223(Circ Arrhythm Electrophysiol. 2012;5:1216-1223.)