Favorable and Unfavorable HLA Class I Alleles and Haplotypes in Zambians Predominantly Infected with Clade C Human Immunodeficiency Virus Type 1

Tang, Jianming; Tang, Shenghui; Lobashevsky, Elena; Myracle, Angela D.; Fideli, U.; Aldrovandi, Grace M.; Allen, Susan; Musonda, Rosemary; Kaslow, Richard A.

doi:10.1128/jvi.76.16.8276-8284.2002

Cited by 133 publications

(144 citation statements)

References 68 publications

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“…11 The A*02-Cw16 haplotype was associated with high viral load in HIV-1, clade C-infected Zambians. 12 Finally, a study of C282Y homozygous hemochromatosis subjects demonstrated a significant association between the A*02 allele and a lower CD 8 þ T-lymphocyte count. 13 This association was not observed in healthy controls carrying the A*02 allele, indicating that the lower count may be related to a locus in LD with the A*02 allele.…”

Section: Discussionmentioning

confidence: 98%

Associations between the human MHC and sustained virologic response in the treatment of chronic hepatitis C virus infection

Rhodes

Erlich

et al. 2008

Genes Immun

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The human major histocompatability complex (MHC) genes encode the human leukocyte antigens, which are important in antigen presentation and regulation of CD8 þ and CD4 þ T cells. Response to therapies in hepatitis C virus (HCV) infection is highly variable (30-80%) and lower response rates have been reported among African Americans (AA; B30%) compared to Caucasian Americans (CA; B50%) infected with genotype-1 viruses. We evaluated whether MHC gene variants were associated with response to therapy and racial differences in AA and CA sustained virologic response (SVR) rates. We genotyped alleles at 8 MHC loci: 3 class I (A, B and C) and 5 class II (DRB1, DQA1, DQB1, DPA1 and DPB1) loci in 373 individuals (179 AA and 194 CA) with genotype-1 HCV infections, who were treated with peginterferon-a-2a and ribavirin. We observed carriage of A*02 (RR ¼ 1.33(1.08-1.64); P ¼ 0.008), B *58 (RR ¼ 1.84(1.24-2.73); P ¼ 0.002) and DPB1*1701 (RR ¼ 1.57(1.09-2.26); P ¼ 0.015) to be associated with SVR after adjustment for other predictors of response. In analysis of AA and CA subgroups separately, we observed potential, though not statistically significant, differences in these MHC associations. Variation in the immunogenetic background of HCV-infected individuals might account for some observed variation in viral-specific immunity and courses of disease. In this regard, future studies examining broader patient populations are warranted.

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Section: Discussionmentioning

confidence: 98%

Associations between the human MHC and sustained virologic response in the treatment of chronic hepatitis C virus infection

Rhodes

Erlich

et al. 2008

Genes Immun

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“…To further evaluate the relationship between the specificity of CD8 ϩ T-cell responses and immune control, we investigated HLA-B*13, a class I allele previously linked with successful immune control (16,36) but for which comprehensive analyses of the CD8 ϩ T-cell response had not been undertaken. The initial study cohort comprised 1212 antiretroviral therapy-naïve adults from Durban, South Africa, with chronic HIV-1 C clade infections.…”

Section: Human Immunodeficiency Virus (Hiv)-specific Cd8mentioning

confidence: 99%

Control of Human Immunodeficiency Virus Type 1 Is Associated with HLA-B*13 and Targeting of Multiple Gag-Specific CD8⁺T-Cell Epitopes

Honeyborne

Prendergast

Pereyra

et al. 2007

J Virol

134

136

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To better understand relationships between CD8؉ T-cell specificity and the immune control of human immunodeficiency virus type 1 (HIV-1), we analyzed the role of HLA-B*13, an allele associated with low viremia, in a cohort of 578 C clade-infected individuals in Durban, South Africa. Six novel B*13-restricted cytotoxic T lymphocyte epitopes were defined from analyses of 37 B*13-positive subjects, including three Gag epitopes. These B*13-restricted epitopes contribute to a broad Gag-specific CD8 ؉ response that is associated with the control of viremia. These data are consistent with data from studies of other HLA-class I alleles associated with HIV control that have shown that the targeting of multiple Gag epitopes is associated with relative suppression of viremia.

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“…The design and conduct of these studies have been described elsewhere (9,18,28). The selection of mostly HIV-1 subtype Cinfected Zambians (n ϭ 423) was based on the availability of HIV-1 RNA measurements.…”

Section: Subjectsmentioning

confidence: 99%

“…Among B58s alleles (all B*57 alleles, B*5801-*5802, and B*1516-*1517) (25). The HLA-B*57 alleles have consistently been associated with a favorable disease course in populations with different HIV-1 viral subtypes and ethnic backgrounds (1,6,11,28,30). However, assessment of the other B58s alleles has been relatively sparse (4,10,14).…”

mentioning

confidence: 99%

Human Leukocyte Antigen B58 Supertype and Human Immunodeficiency Virus Type 1 Infection in Native Africans

Lazaryan¹,

Lobashevsky²,

Mulenga³

et al. 2006

J Virol

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Human leukocyte antigen (HLA) class I alleles can be grouped into supertypes according to their shared peptide binding properties. We examined alleles of the HLA-B58 supertype (B58s) in treatment-naïve human immunodeficiency virus type 1 (HIV-1)-seropositive Africans (423 Zambians and 202 Rwandans). HLA-B and HLA-C alleles were resolved to four digits by a combination of molecular methods, and their respective associations with outcomes of HIV-1 infection were analyzed by statistical procedures appropriate for continuous or categorical data. The effects of the individual alleles on natural HIV-1 infection were heterogeneous. In HIV-1 subtype C-infected Zambians, the mean viral load (VL) was lower among B*5703 (P ‫؍‬ 0.01) or B*5703-Cw*18 (P < 0.001) haplotype carriers and higher among B*5802 (P ‫؍‬ 0.02) or B*5802-Cw*0602 (P ‫؍‬ 0.03) carriers. The B*5801-Cw*03 haplotype showed an association with low VL (P ‫؍‬ 0.05), whereas B*5801 as a whole did not. Rwandans with HIV-1 subtype A infection showed associations of B*5703 and B*5802 with slow (P ‫؍‬ 0.06) and rapid (P ‫؍‬ 0.003) disease progression, respectively. In neither population were B*1516-

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Favorable and Unfavorable HLA Class I Alleles and Haplotypes in Zambians Predominantly Infected with Clade C Human Immunodeficiency Virus Type 1

Cited by 133 publications

References 68 publications

Associations between the human MHC and sustained virologic response in the treatment of chronic hepatitis C virus infection

Associations between the human MHC and sustained virologic response in the treatment of chronic hepatitis C virus infection

Control of Human Immunodeficiency Virus Type 1 Is Associated with HLA-B*13 and Targeting of Multiple Gag-Specific CD8⁺T-Cell Epitopes

Human Leukocyte Antigen B58 Supertype and Human Immunodeficiency Virus Type 1 Infection in Native Africans

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Favorable and Unfavorable HLA Class I Alleles and Haplotypes in Zambians Predominantly Infected with Clade C Human Immunodeficiency Virus Type 1

Cited by 133 publications

References 68 publications

Associations between the human MHC and sustained virologic response in the treatment of chronic hepatitis C virus infection

Associations between the human MHC and sustained virologic response in the treatment of chronic hepatitis C virus infection

Control of Human Immunodeficiency Virus Type 1 Is Associated with HLA-B*13 and Targeting of Multiple Gag-Specific CD8+T-Cell Epitopes

Human Leukocyte Antigen B58 Supertype and Human Immunodeficiency Virus Type 1 Infection in Native Africans

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Control of Human Immunodeficiency Virus Type 1 Is Associated with HLA-B*13 and Targeting of Multiple Gag-Specific CD8⁺T-Cell Epitopes