Faunistic study on the family Meloidae (Coleoptera) of Ankara province (Turkey)

Demir, Muhammed Arif; Kabalak, Mahmut

doi:10.15671/hjbc.788113

Cited by 2 publications

(3 citation statements)

References 15 publications

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“…This is partly because DTX can inhibit cell mitosis in both S and G2/M phases, whereas PTX can inhibit cell mitosis only in the G2/M phase. In addition, DTX has a longer retention time in tumor cells in comparison to PTX due to its better uptake into cells, slower elimination from cells, and longer terminal elimination half-life from tumor tissue . The only drawback of Taxotere, the only DTX product in the market, seems to be that it contains a high Tween 80 and is applied with alcohol.…”

Section: Results and Discussionmentioning

confidence: 99%

“…In addition, DTX has a longer retention time in tumor cells in comparison to PTX due to its better uptake into cells, slower elimination from cells, and longer terminal elimination half-life from tumor tissue. 18 The only drawback of Taxotere, the only DTX product in the market, seems to be that it contains a high Tween 80 and is applied with alcohol. There is information that a high Tween 80 content causes more side effects and hypersensitivity.…”

Section: Results and Discussionmentioning

confidence: 99%

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Co-Delivery of siRNA and Docetaxel to Cancer Cells by NLC for Therapy

Şenel,

Başaran,

Akyıl

et al. 2024

ACS Omega

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The present study aims to develop a delivery system that can carry small interference RNA (siRNA) with smallmolecule chemotherapeutic drugs, which can be used in cancer treatment. The drug delivery system combines the advantages of a therapeutic agent with two different mechanisms to ensure that it is used efficiently for cancer therapy. In this study, a nanostructured lipid carrier system was prepared, Docetaxel was loaded to these systems, and the Eph siRNA was adsorbed to the outer surface. In addition, DOTAP was added to the lipophilic phase to load a positive charge on the lipidic structure for interaction with the cells. Moreover, characterization, cytotoxicity, and transfection procedures were performed on the whole system. This candidate system was also compared to Taxotere, which is the first approved Docetaxel-containing drug on the market. Given the results, it was determined that the particle size of NLC-DTX was 165.3 ± 3.5 nm, the ζ potential value was 38.2 ± 1.7 mV, and the PDI was 0.187 ± 0.024. Entrapment efficacy of nanoparticles was found to be 92.89 ± 0.21%. It was determined that the lipidic system prepared in vitro release analyses were able to provide sustained release and exhibit cytotoxicity, even at doses lower than the dose used for Taxotere. The formulations prepared had a higher level of effect on cells when compared with pure DTX and Taxotere, but they also exhibited time-dependent cytotoxicity. It was also observed that the use of Eph siRNA together with the chemotherapeutic agent via formulation also contributed to this cell death. The results of the present study indicate that there is a promising carrier system in order to deliver hydrophilic nucleic acids, such as siRNA, together with lipophilic drugs in cancer treatment.

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Section: Results and Discussionmentioning

confidence: 99%

Section: Results and Discussionmentioning

confidence: 99%

Co-Delivery of siRNA and Docetaxel to Cancer Cells by NLC for Therapy

Şenel,

Başaran,

Akyıl

et al. 2024

ACS Omega

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“…Elements of the visual system of fish are laid down at an early stage of embryogenesis. The quality of fish vision depends on many factors, such as the density of the retinal photoreceptors, types of photoreceptor cells, the size of the eye, the lens, and the vitreous body [ 2 , 3 ]. It should be noted that the eye is not the main sense organ for all groups of fish, nor for this class of vertebrates as a whole; thus, fish have wide variations in eye size and shape.…”

Section: Introductionmentioning

confidence: 99%

Some Aspects of Development and Histological Structure of the Visual System of Nothobranchius Guentheri

Nikiforov-Nikishin

Irkha

Kochetkov

et al. 2021

Animals

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In this, work some aspects of the development of the visual system of Nothobranchius guentheri at the main stages of ontogenesis were described for the first time. It was possible to establish that the formation of the visual system occurs similarly to other representatives of the order Cyprinodontiformes, but significantly differs in terms of the individual stages of embryogenesis due to the presence of diapause. In the postembryonic period, there is a further increase in the size of the fish’s eyes and head, to the proportions characteristic of adult fish. The histological structure of the eye in adult N. guentheri practically does not differ from most teleost fish living in the same environmental conditions. The study of the structure of the retina showed the heterogeneity of the thickness of the temporal and nasal areas, which indicates the predominant role of peripheral vision. Morphoanatomical measurements of the body and eyes of N. guentheri showed that their correlation was conservative. This indicates an important role of the visual system for the survival of fish in natural conditions, both for the young and adults. In individuals of the older age group, a decrease in the amount of sodium (Na) and an increase in magnesium (Mg) and calcium (Ca) were found in the eye lens. Such changes in the elemental composition of the lens can be a sign of the initial stage of cataractogenesis and disturbances in the metabolism of lens fibers as a result of aging. This allows us to propose N. guentheri as a model for studying the structure, formation, and aging of the visual and nervous systems.

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Faunistic study on the family Meloidae (Coleoptera) of Ankara province (Turkey)

Cited by 2 publications

References 15 publications

Co-Delivery of siRNA and Docetaxel to Cancer Cells by NLC for Therapy

Co-Delivery of siRNA and Docetaxel to Cancer Cells by NLC for Therapy

Some Aspects of Development and Histological Structure of the Visual System of Nothobranchius Guentheri

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