Fatty liver of pregnancy and its relationship to tetracycline therapy

Tigecycline-induced acute pancreatitis: case report and literature review

“…Medications in the tetracycline class, including tetracycline, minocycline and oxytetracycline, have been associated with acute pancreatitis [6][7][8]. Although the exact mechanism of tetracyclineinduced pancreatitis is still unknown, there have been at least three different mechanisms hypothesised, including (i) formation of a toxic metabolite, (ii) hypertriglyceridaemia and (iii) a high biliary concentration.…”

Tetracycline Nephrotoxicity and Nonoliguric Acute Renal Failure

“…6 Although these cases are reported as hepatic failure primarily, in several the renal and electrolyte abnormalities were more promi¬ nent than the hepatic changes. An unusual Kunin.27 Urinalysis, determination of the level of drug in serum, and tests of renal function should be carried out frequently for proper management of these patients.…”

“…3,6 Another potentially fatal side effect of this antibiotic drug is nephrotoxicity. Acute renal failure associated with tetracycline is not accompanied by oliguria.…”

Antibiotics in pregnancy: Toxicity and teratogenicity

“…Furthermore, the occurrence of congenital limb malformations due to tetracyclines has been discussed (19). Severe adverse effects, such as lethal fatty liver degeneration, were reported in pregnant women undergoing tetracycline therapy (often after a high dosage) (20,21). The danger of side-effects with respect to the mother is probably greatest during the last trimester of pregnancy.…”