Fatty liver index<i>vs</i>waist circumference for predicting non-alcoholic fatty liver disease

Motamed, Nima; Sohrabi, Masoudreza; Ajdarkosh, Hossein; Hemmasi, Gholamreza; Maadi, Mansooreh; Sayeedian, Fatemeh Sima; Pirzad, Reza; Abedi, Khadijeh; Aghapour, Sivil; Fallahnezhad, Mojtaba; Zamani, Farhad

doi:10.3748/wjg.v22.i10.3023

Cited by 100 publications

(95 citation statements)

References 32 publications

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“…In contrast with our study, Motamed et al suggested higher cut-off values of FLI for females because of the protective effect of estrogen in females (11).…”

Section: U N C O R R E C T E D P R O O Fcontrasting

confidence: 99%

“…Our findings indicated that the FLI has a good performance in predicting NAFLD with an AUC of 0.84, based on controlled attenuation parameter (CAP) detection, which was in line with the results of a baseline cohort study in Iran that showed FLI has a good predicting power in the diagnosis of NAFLD, with an AUC of 0.865; however, in this cohort study, ultrasound was used for diagnosis of NAFLD (11). Also, in another study by Xiaolin Huang on 8626 Chinese adults, the AUC of FLI was 0.834 for predicting NAFLD (20).…”

Section: Discussionsupporting

confidence: 88%

“…Also, the cut-off values of FLI in our study were lower than the cut-off values proposed by Xiaolin and Motamed in China and Iran populations, respectively (11,20).…”

Section: U N C O R R E C T E D P R O O Fcontrasting

confidence: 94%

“…In the recent years, a number of indices have been considered to predict fatty changes of the liver including the fatty liver index (FLI), hepatic steatosis index (HIS), NAFLD liver fat score, and Steato test (ST) (11). FLI, developed by Bedogni et al in 2006, is a simple and accurate index based on routine clinical and anthropometric measurements including body mass index (BMI), waist circumference (WC), triglyceride (TG), and gamma glutamyltransferase (GGT) (12).…”

Section: Introductionmentioning

confidence: 99%

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Fatty Liver Index (FLI) in Predicting Non-alcoholic Fatty Liver Disease (NAFLD)

et al. 2018

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Background: Non-alcoholic fatty liver disease (NAFLD) is considered as the most common chronic liver disease, which can contribute to some clinical conditions varying from simple steatosis to hepatic cirrhosis. Consequently, the early diagnosis of NAFLD is vital. The present study aimed at investigating the ability of FLI (fatty liver index) in predicting NAFLD. Methods: A total of 212 individuals over the age of 18 years (103 males and 109 females) were recruited from those admitted to a gastrointestinal clinic in Mashhad, northeastern Iran. Anthropometric parameters were measured and blood samples were collected. Hepatic steatosis and fibrosis were identified by FibroScan. FLI from body mass index, waist circumference (WC), triglyceride, and gamma glutamyltransferase data were calculated. Logistic regression was applied to establish a relationship among FLI, hepatic steatosis, and fibrosis. The sensitivity and specificity of FLI and its optimal cut-off point were detected by receiver operating characteristic analysis.

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“…In contrast with our study, Motamed et al suggested higher cut-off values of FLI for females because of the protective effect of estrogen in females (11).…”

Section: U N C O R R E C T E D P R O O Fcontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 88%

“…Also, the cut-off values of FLI in our study were lower than the cut-off values proposed by Xiaolin and Motamed in China and Iran populations, respectively (11,20).…”

Section: U N C O R R E C T E D P R O O Fcontrasting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Fatty Liver Index (FLI) in Predicting Non-alcoholic Fatty Liver Disease (NAFLD)

et al. 2018

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“…Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases around the world (1,2) and its prevalance has grown due to unhealthy life styles (3). The disease has a wide spectrum from simple steatosis to nonalcoholic steatohepatitis (NASH), which is hepatic steatosis accompanied by inflammation or liver cell injury with or without fibrosis (4).…”

Section: Introductionmentioning

confidence: 99%

Interpretation of Serum Visfatin Level in Relation to Hepatic Injury is Probably Gender Dependent in Nonalcoholic Fatty Liver Disease

et al. 2017

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Background: Studies on the association between visfatin and nonalcoholic fatty liver disease (NAFLD) have contradictory results and the role of this adipokine in NAFLD pathogenesis has remained unclear. In vitro studies indicate that visfatin expression could be regulated by sex hormones. Testosterone down-regulates visfatin expression in pre-adipocytes and estrogen increases its expression in adipocytes. Objectives: This study aimed at exploring whether the association between serum visfatin and markers of hepatic injury is the same for both genders in patients with NAFLD. Methods: In this cross-sectional study, 62 consecutive patients (32 males and 30 females) with NAFLD were recruited. Fasting serum visfatin, caspase-cleaved cytokeratin 18 (cCK18), total soluble cytokeratin 18 (CK18), liver enzymes (AST and ALT), insulin, and lipidglucose profile was measured. Anthropometric measurements, fibroscan and assessment of dietary intake and physical activity level, were performed for each participant. Two independent sample t tests, chi-square test, univariate, and multiple linear regression (to adjust for confounding factors) were used to analyze the data. Results: In males, serum visfatin had a significant positive association with serum Aspartate Aminotransferase (AST) (B = 0.47, P = 0.009), alanine aminotransferase (ALT) (B = 0.40, P = 0.035), CK18 (B = 0.50, P = 0.008), and cCK18 (B = 0.47, P = 0.012). In females, serum visfatin only had a weak association with CK18 (B = 0.37, P = 0.045). Instead, higher body mass index (BMI) was significantly associated with increased serum CK18 (B = 0.44, P = 0.02), cCK18 (B = 0.42, P = 0.02), controlled attenuation parameter (CAP) (B = 0.39, P = 0.049), and liver stiffness measurement (LSM) (B = 0.40, P = 0.03) in females. Higher waist to hip ratio was also significantly related to serum AST (B = 0.37, P = 0.04), ALT (B = 0.50, P = 0.02), CK18 (B = 0.41, P = 0.03), cCK18 (B = 0.37, P = 0.04), and CAP (B = 0.39,

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The association between nonalcoholic fatty liver disease and corrected QT interval prolongation among generally healthy Iranian population: Fasa Cohort Study (FACS)

Naderi

Farjam

Sani

et al. 2023

Clinical Cardiology

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Background There are limited studies about the association between nonalcoholic fatty liver disease (NAFLD) and corrected QT interval (QTc) prolongation worldwide. Hypothesis Therefore, we designed the current study to determine this association in a large cohort of a generally healthy population. Methods We analyzed the data of 4603 individuals aged 35–70 who participated in the Fasa Cohort Study (FACS). Based on 12‐lead electrocardiograms, QT intervals were calculated and corrected by Bazzet's formula. A QTc interval of more than 430 ms in men and 450 ms in women was considered prolonged. The Fatty Liver Index was used to identify the participants with NAFLD. Results Of all participants, 1550 (33.6%) met the NAFLD criteria. In subjects of both genders with NAFLD, the mean values of the QTc interval were considerably higher than in those without NAFLD (p < .001). After adjusting for a wide range of confounders, including age, gender, smoking status, physical activity, total cholesterol, high‐density lipoprotein‐cholesterol levels, diabetes, and hypertension status, in linear regression analysis, the standardized β coefficient of QTc interval among participants with NAFLD was 2.56 ms (95% confidence interval [CI]: 0.49–4.64). After controlling the same confounders, the odds ratio of NAFLD for a prolonged QTc interval in men was 1.47 (95% CI: 1.18–1.84; p < .001) and in women was 1.39 (95% CI: 1.15–1.68; p < .001) using logistic regression analysis. Conclusions NAFLD was a risk factor for QTc interval prolongation. Awareness about the risk of NAFLD in increasing the potential cardiac arrhythmias should be raised to lower cardiac mortality.

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Fatty liver indexvswaist circumference for predicting non-alcoholic fatty liver disease

Abstract: Although FLI had acceptable discriminatory power in the diagnosis of NAFLD, WC was a simpler and more accessible index with a similar performance.

Cited by 100 publications

References 32 publications

Fatty Liver Index (FLI) in Predicting Non-alcoholic Fatty Liver Disease (NAFLD)

Fatty Liver Index (FLI) in Predicting Non-alcoholic Fatty Liver Disease (NAFLD)

Interpretation of Serum Visfatin Level in Relation to Hepatic Injury is Probably Gender Dependent in Nonalcoholic Fatty Liver Disease

The association between nonalcoholic fatty liver disease and corrected QT interval prolongation among generally healthy Iranian population: Fasa Cohort Study (FACS)

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