Fatty liver index for hyperuricemia diagnosis: a community-based cohort study

Qu, Jianchang; Dou, Jingtao; Wang, Anping; Liu, Yingshu; Lin, Li; Chen, Kang; Zang, Li; Mu, Yiming

doi:10.1186/s12902-022-01030-6

Cited by 5 publications

(4 citation statements)

References 29 publications

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“…29 Simple measures such as BMI, WC and FLI have been independently correlated with MAFLD. [30][31][32] These findings were validated in the present study. BMI, WC and FLI were better predictors of MAFLD than TC, TG and FPG.…”

Section: Open Accesssupporting

confidence: 87%

Diagnostic value of triglyceride–glucose index and related parameters in metabolism-associated fatty liver disease in a Chinese population: a cross-sectional study

Yu,

Xie,

Peng

et al. 2023

BMJ Open

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ObjectiveOur study aimed to explore the diagnostic value of triglyceride–glucose (TyG) and its related parameters in metabolism-associated fatty liver disease (MAFLD).DesignA cross-sectional study of residents who attended medical checkups at the First Hospital of Nanping City, Fujian Medical University, between 2015 and 2017.SettingOne participation centre.Participants2605 subjects met the inclusion–exclusion criteria and were grouped according to whether they had MAFLD.ResultsThe TyG index and its associated parameters are positively associated with the risk of developing MAFLD (p<0.001). Restriction cube spline analysis showed a significant dose–response relationship between the TyG index and MAFLD. The risk of developing MAFLD increases significantly with a higher TyG index. After adjusting for confounders, this relationship remains (OR: 4.89, 95% CI 3.98 to 6.00). The areas under the receiver operating characteristic curves of the TyG index for MAFLD detection were 0.793 (0.774 to 0.812). The areas under the curve (AUC) of TyG-related parameters were improved, among which TyG-waist circumference (TyG-WC) showed the largest AUC for MAFLD detection (0.873, 95% CI 0.860 to 0.887). In addition, the best cut-off value of the TyG-WC was 716.743, with a sensitivity and specificity of 88.7% and 71.4%, respectively.ConclusionThe TyG index effectively identifies MAFLD, and the TyG-related parameters improved the identification and diagnosis of MAFLD, suggesting that TyG-related parameters, especially TyG-WC, may be a useful marker for diagnosing MAFLD.

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Section: Open Accesssupporting

confidence: 87%

Diagnostic value of triglyceride–glucose index and related parameters in metabolism-associated fatty liver disease in a Chinese population: a cross-sectional study

Yu,

Xie,

Peng

et al. 2023

BMJ Open

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“…12 Hyperuricemia was defined as a uric acid level of > 420 µmol/L. 13 Statistical Analysis SPSS 25.0 was used to process and analyze all statistics. Measurement data for normally distributed continuous variables were expressed as means ± standard deviations, and the Student's t-test method was used for inter-group comparison.…”

Section: Diagnostic Criteriamentioning

confidence: 99%

The Interaction Between Age and Risk Factors for Diabetes and Prediabetes: A Community-Based Cross-Sectional Study

Yan¹,

Cai²,

Chen³

et al. 2023

DMSO

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Objective This study aimed to investigate the interaction between age groups and risk factors for diabetes and prediabetes in Shanghai communities and to identify the effect of age on other risk factors for diabetes and prediabetes. Methods This study recruited 3540 participants with undiagnosed diabetes or prediabetes in 14 communities in Shanghai from February to August 2019. All participants underwent a comprehensive examination, including filling out a detailed questionnaire, physical examination, 75 g oral glucose tolerance test, and blood sample collection. In addition, logistic regression was used to analyze the interaction between age and risk factors for prediabetes and diabetes. Results The statistical analysis included 2776 people. In this study, the prevalence of diabetes and prediabetes were 15.1% and 52.3%, respectively. The prevalence of diabetes and prediabetes is higher in the elderly than in the middle-aged group. Among the risk factors for diabetes, overweight was associated with higher age ( P -interaction 0.028). In addition, among the risk factors for prediabetes, a high level of education was associated with higher age ( P -interaction 0.039) and elevated serum cholesterol level was associated with lower age ( P -interaction 0.019). Conclusion This study confirmed an interaction between age and other influencing factors, which may be important in explaining differences in risk factors for diabetes and prediabetes in the middle-aged and elderly populations. Community health facilities can provide health guidance to people of different age groups to prevent and control prediabetes and diabetes.

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“…A high FLI is associated with increased insulin resistance [31], oxidative protein products, and in ammatory marker [32], suggesting that the risk of MACE may increase similarly to the presence of MetS. FLI is also known to be associated with metabolic diseases [31,[33][34][35], nonmetabolic diseases [36-39], and mortality [40,41] beyond the diagnosis method of hepatic steatosis. Similar to previous study ndings [14,18,[40][41][42], our report found that high FLI was associated with elevated risk of MACE, all-cause mortality, and liver-related mortality.…”

Section: Subgroup Analysismentioning

confidence: 99%

The association of fatty liver index and metabolic syndrome with cardiovascular outcomes, liver-related mortality, and all-cause mortality: A nationwide cohort study

Park,

Kim

et al. 2024

Preprint

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We investigated the risk of cardiovascular events, all-cause mortality, and liver-related mortality according to the presence of metabolic syndrome (MetS) and fatty liver index (FLI). In this retrospective longitudinal population-based cohort study, we used Korean National Health Insurance Service data from 2009 to 2012. Nonalcoholic fatty liver disease (NAFLD) was defined as FLI ≥ 60. Risk of all-cause mortality, liver-related mortality, and major adverse cardiovascular events (MACE) including myocardial infarction (MI), stroke, heart failure (HF), and cardiovascular disease (CVD)-related mortality was assessed according to the presence of MetS and FLI among adults (aged 40 to 80 years) who underwent health examinations (n = 769,422). During a median 8.59 years of follow up, 44,356 (5.8%) cases of MACE, 24,429 (3.2%) cases of all-cause mortality, and 1,114 (0.1%) cases of liver-related mortality were detected in the entire cohort. When the FLI < 30 without MetS group was set as a reference, the FLI ≥ 60 with MetS group had the highest risk of MACE (adjusted hazard ratio [aHR] 2.05, 95% confidence interval [CI] 1.98–2.13) and all-cause mortality (aHR 1.96, 95% CI 1.86–2.07). The risk of liver-related mortality (aHR 10.71, 95% CI 8.05–14.25) was highest in the FLI ≥ 60 without MetS group. The FLI ≥ 60 with MetS group had a higher risk of MACE (aHR 1.39, 95%CI 1.28–1.51), a lower risk of liver-related mortality (aHR 0.44, 95%CI 0.33–0.59), and no significant difference in all-cause mortality compared with the FLI ≥ 60 without MetS group. The FLI ≥ 60 with MetS group was associated with the highest risk of MACE and the FLI ≥ 60 without MetS group had the highest risk liver-related mortality, but there was no significant difference in all-cause mortality between two groups.

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Fatty liver index for hyperuricemia diagnosis: a community-based cohort study

Cited by 5 publications

References 29 publications

Diagnostic value of triglyceride–glucose index and related parameters in metabolism-associated fatty liver disease in a Chinese population: a cross-sectional study

Diagnostic value of triglyceride–glucose index and related parameters in metabolism-associated fatty liver disease in a Chinese population: a cross-sectional study

The Interaction Between Age and Risk Factors for Diabetes and Prediabetes: A Community-Based Cross-Sectional Study

The association of fatty liver index and metabolic syndrome with cardiovascular outcomes, liver-related mortality, and all-cause mortality: A nationwide cohort study

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