Fatty liver disease in living liver donors: a single‐institute experience of 220 donors

Wen, Fang; Noda, Momoko; Gotoh, Kunihito; Morooka, Yuki; Noda, Takehiro; Kobayashi, Shogo; Doki, Yuichiro; Eguchi, Hidetoshi; Umeshita, Koji

doi:10.1111/tri.14005

Cited by 4 publications

(4 citation statements)

References 38 publications

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“…In this study, we demonstrated that 14.2% of living donors developed fatty liver after donation hepatectomy. Consistently, recent single‐institution studies in Japan revealed that the incidence of fatty liver in the living donor after donation hepatectomy was 3.8%–14.5% 12,13 . In the general population, a cross‐sectional study of Japanese adults ( n = 11 714) revealed NAFLD in 20.4% of subjects 14 .…”

Section: Discussionsupporting

confidence: 54%

“…Consistently, recent single‐institution studies in Japan revealed that the incidence of fatty liver in the living donor after donation hepatectomy was 3.8%–14.5%. 12 , 13 In the general population, a cross‐sectional study of Japanese adults ( n = 11 714) revealed NAFLD in 20.4% of subjects. 14 Another study of 8352 adult subjects who received a health checkup revealed that the prevalence of NAFLD was 29.7%.…”

Section: Discussionmentioning

confidence: 99%

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Long‐term risk of a fatty liver in liver donors

Goto

Kawamura

Watanabe

et al. 2023

Annals of Gastroent Surgery

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Aim Approximately 30 years have passed since the first experience of living donor liver transplantation. The time to evaluate the long‐term safety of living donors has been fulfilled. Meanwhile, nonalcoholic fatty liver disease is increasingly common and a critical problem. The aim of this study was to evaluate the safety of living donor, focusing on fatty liver postdonation hepatectomy. Methods Living donors (n = 212, 1997–2019) were evaluated by computed tomography (CT) at >1‐year postdonation. A liver to spleen (L/S) ratio of <1.1 was defined as fatty liver. Results Among 212 living liver donors, 30 (14.2%) detected fatty liver at 5.3 ± 4.2 years postdonation. The cumulative incidence rates of fatty liver were 3.1%, 12.1%, 22.1%, and 27.7% at 2, 5, 10, and 15 years postdonation, respectively. Of 30 subjects who developed fatty liver, 18 (60%) displayed a severe steatosis (L/S ratio <0.9). Five (16.7%) had a prior history of excessive alcohol abuse. More than 30% developed metabolic syndrome including obesity, hyperlipidemia, and diabetes. Although six (20%) had a Fib‐4 index of >1.3, which included a case with a Fib‐4 index of >2.67, no significant increased Fib‐4 index was observed in the subjects with fatty liver as compared to those without fatty liver (p = 0.66). The independent predictive risk factors for developing fatty liver were male sex, pediatric recipient, and higher body mass index (>25) at donation. Conclusion Living donors with risk factors for developing fatty liver should be carefully followed‐up for the prevention and management of metabolic syndrome.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Long‐term risk of a fatty liver in liver donors

Goto

Kawamura

Watanabe

et al. 2023

Annals of Gastroent Surgery

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“…According to results reported using the Clavien-Dindo classification, the frequency of life-threatening complications was minimal [27, 33], and hepatobiliary complications were reported in approximately 2~18% of cases [27,34]. Nevertheless, some donors may require medical treatment or prolonged hospitalization [35][36][37], which can reduce health-related quality of life [38] and threaten mental health, such as the development of anxiety or alcohol use disorders [7]. Donor safety after surgery is of utmost importance [39].…”

Section: Discussionmentioning

confidence: 99%

Research Trends on Living Donors for Liver Transplantation: A Text Network Analysis and Topic Modeling

Choi,

Kim,

Seo

2024

J Korean Acad Fundam Nurs

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Purpose: This study aimed to identify research topics and trends on living liver donors over time through text network analysis and topic modeling.Methods: Five electronic databases (PubMed, CINAHL, Embase, Web of Science, and PsycINFO) were reviewed for studies published through September 2023, and 392 studies were included. Text network analysis was used to identify the basic characteristics and centrality of the network. The topics were named after extracting meaningful topics through topic modeling using latent Dirichlet allocation.Results: A total of 1,111 keywords were extracted from the abstracts of 392 selected studies, among which “length of stay,” “morbidity,” “mortality,” “pain,” and “quality of life” showed high frequency and centrality. Through topic modeling analysis, the following four topics were derived: objective health indicators (topic 1), subjective health indicators (topic 2), hepatobiliary-related indicators (topic 3), and early health indicators (topic 4). An analysis of trends in these topics over time showed that the proportion of topics 1, 3, and 4 increased or remained stable. In contrast, there was no significant change in topic 2, representing subjective health indicators.Conclusion: This study explored research trends on living liver donors using text network analysis and topic modeling. Based on the main topics derived, research on postoperative outcomes for living liver donors has focused on objective health indicators, hepatobiliary-related indicators, and early health indicators compared to subjective health indicators. We suggest that future studies utilize integrated indicators of physical and psychosocial aspects.

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“…The controlled attenuation parameter (CAP) is a novel ultrasound-based elastography method for detection of the grade of steatosis, an important parameter in the assessment of a liver donor, and mainly associated with male sex and high body mass index [ 32 ].…”

Section: New Ultrasound Techniques In Liver Transplantationmentioning

confidence: 99%

Liver Transplant Imaging prior to and during the COVID-19 Pandemic

Bellini

Fresilli

Lauro

et al. 2022

BioMed Research International

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Background. The suspension of the surgical activity, the burden of the infection in immunosuppressed patients, and the comorbidities underlying end-stage organ disease have impacted transplant programs significantly, even life-saving procedures, such as liver transplantation. Methods. A review of the literature was conducted to explore the challenges faced by transplant programs and the adopted strategies to overcome them, with a focus on indications for imaging in liver transplant candidates. Results. Liver transplantation relies on an appropriate imaging method for its success. During the Coronavirus Disease 2019 (COVID-19) pandemic, chest CT showed an additional value to detect early signs of SARS-CoV-2 infection and other screening modalities are less accurate than radiology. Conclusion. There is an emerging recognition of the chest CT value to recommend its use and help COVID-19 detection in patients. This examination appears highly sensitive for liver transplant candidates and recipients, who otherwise would have not undergone it, particularly when asymptomatic.

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Fatty liver disease in living liver donors: a single‐institute experience of 220 donors

Cited by 4 publications

References 38 publications

Long‐term risk of a fatty liver in liver donors

Long‐term risk of a fatty liver in liver donors

Research Trends on Living Donors for Liver Transplantation: A Text Network Analysis and Topic Modeling

Liver Transplant Imaging prior to and during the COVID-19 Pandemic

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