Fatty liver deposition and sparing: a pictorial review

Décarie, Patrick-Olivier; Lepanto, Luigi; Billiard, Jean-Sébastien; Olivié, Damien; Murphy-Lavallée, Jessica; Kauffmann, Claude; Tang, An

doi:10.1007/s13244-011-0112-5

Cited by 75 publications

(56 citation statements)

References 14 publications

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“…Even though many studies reported an association between liver fibrosis and hepatic iron overload [22,29] , we did not perform histopathological studies, since biopsy sample taking is not ethically justified in healthy individuals with no clinical indication. It should be noted that since deposition of iron and fat in liver can be heterogeneous [34] , samples obtained by biopsy may not necessarily represent the status of liver iron and fat in all sections of the liver. Of course, imaging evaluation of hepatic steatosis using MRI has been reported as a reliable alternative for the histological study of liver [35] .…”

Section: Discussionmentioning

confidence: 99%

Central Obesity and Liver Iron Content: A Noninvasive Assessment in General Population by Magnetic Resonance Imaging

Radmard

Taheri²,

Seresht³

et al. 2016

Ann Nutr Metab

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Background/Aim: Existing evidence points to an altered status of iron metabolism in obesity. We aimed to investigate whether central obesity is independently associated with estimated liver iron content (liver T2* value) in general population that used the noninvasive assessment method by MRI. Methods: The study was carried out on 200 subjects randomly selected from the Golestan Cohort Study who underwent abdominal MRI. Quantitative T2* maps of entire cross-sectional area of liver were calculated using a semi-automated software for estimating the levels of iron content. Segmentation and calculation of visceral (VFA) and subcutaneous fat area (SFA) were also performed. Results: There was no significant difference in mean liver T2* values between obese (body mass index, BMI >30 kg/m²) and non-obese (BMI ≤30 kg/m²) subjects. After controlling for other covariates, no statistically significant association was detected between liver T2* values and VFA, SFA and VFA/SFA ratio. The drop in the relative signal intensity as an indicator of steatosis and serum ferritin predicted liver T2* values that almost had the same strength (standardized β of -0.41 and -0.41, respectively). Conclusions: Central obesity indices are not correlated with estimated liver iron content by MRI. Hepatic steatosis and serum ferritin seem to be the best predictors of hepatic T2* value. Since central obesity indices were not direct predictors of hepatic T2* value after the adjustment for confounding factors, it is possible that lipid accumulation in the liver locally, but not systematically, influences hepatic iron metabolism.

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Section: Discussionmentioning

confidence: 99%

Central Obesity and Liver Iron Content: A Noninvasive Assessment in General Population by Magnetic Resonance Imaging

Radmard

Taheri²,

Seresht³

et al. 2016

Ann Nutr Metab

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“…Furthermore, several recent studies have used imaging methods to demonstrate that VAT, rather than subcutaneous abdominal fat (i.e. SAT), has more influence than BMI in terms of predicting the presence of NAFLD [94][95][96][97][98][99]. In one such study, obese subjects with hepatic steatosis had higher ratios of truncal:total body fat compared with similarly obese persons without fatty liver [95].…”

Section: Nonalcoholic Fatty Liver Disease Physical Activity and Adimentioning

confidence: 99%

“…In one such study, obese subjects with hepatic steatosis had higher ratios of truncal:total body fat compared with similarly obese persons without fatty liver [95]. Nevertheless, the sensitivity and specificity of available imaging methods for measuring liver fat content are unsatisfactory compared to proton ( 1 H) magnetic resonance spectroscopy; the latter modality is usually not available outside a research setting [97][98][99][100][101][102][103]. Conflicting results on the accuracy of different modalities have been 1.…”

Section: Nonalcoholic Fatty Liver Disease Physical Activity and Adimentioning

confidence: 99%

“…Conflicting results on the accuracy of different modalities have been 1. EPIDEMIOLOGY AND CLINICAL MANAGEMENT OF VISCERAL OBESITY reported, which may be related both to an inadequate "gold standard" (liver biopsy, also burdened by conspicuous sampling errors, is unusually performed in this experimental context) and to technical factors [99,102,103].…”

Section: Nonalcoholic Fatty Liver Disease Physical Activity and Adimentioning

confidence: 99%

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Beyond Nutrition Is There Any Role for Physical Activity in Nonalcoholic Fatty Liver Disease Therapy?

Tarantino¹,

Finelli

2014

Nutrition in the Prevention and Treatment of Abdominal Obesity

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“…Fatty infiltration of the liver, often induced by chemotherapy, may further worsen US performance in this crucial task [4]. In particular, unusual and heterogeneous forms of fatty deposition, such as geographic liver fatty deposition, may prevent greyscale US from reliably ruling out the presence of liver metastases in cancer patients, even in the absence of any overt and/or suspect focal liver lesion [5]. More recently, the introduction of contrast-enhanced ultrasonography (CEUS) has led to a dramatic improvement in diagnostic accuracy of US in the detection of liver metastases, when compared to conventional greyscale US [2,6].…”

Section: Introductionmentioning

confidence: 99%

Detection of liver metastases in cancer patients with geographic fatty infiltration of the liver: the added value of contrast-enhanced sonography

et al. 2017

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PurposeThe aim of this study is to assess the role of contrast-enhanced ultrasonography (CEUS) in the detection of liver metastases in cancer patients with geographic liver fatty deposition on greyscale ultrasonography (US).MethodsThirty-seven consecutive cancer patients (24 women and 13 men; age, 33 to 80 years; mean, 58.1 years) with geographic liver fatty deposition, but without any detectable focal liver lesion on greyscale US, underwent sulphur hexafluoride-enhanced US. Two readers reported by consensus the presence, size, and location of any detected lesion. All patients underwent magnetic resonance imaging (MRI) as a confirmatory study. Sensitivity, specificity, positive and negative predictive values (PPV and NPV), and accuracy were calculated.ResultsSeven focal liver lesions (size, 4 to 10 mm; mean, 6.1 mm) were detected in 4/37 patients (10.8%): four metastases (size, 5 to 10 mm; mean, 6.7 mm) were detected both by CEUS and MRI, with one hemangioma and two cysts (size range, 4 to 6 mm; mean, 5.3 mm) detected by MRI only. In 1/37 patients (2.7%), CEUS misdiagnosed geographic fatty change as three metastases. In 32/37 patients (86.5%), no lesions were detected. Sensitivity, specificity, PPV, NPV, and accuracy of CEUS were 100% (95% confidence Interval [CI], 1.000 to 1.000), 97.1% (95% CI, 0.914 to 1.027), 75%, 100%, and 97.3%, respectively. No statistically significant differences were found between CEUS and MRI in the detection of focal liver lesions (P=0.480), whereas both of them performed better than baseline US (P<0.001).ConclusionCEUS improves the detection of liver metastases in cancer patients with geographic liver fatty deposition on greyscale US.

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Fatty liver deposition and sparing: a pictorial review

Cited by 75 publications

References 14 publications

Central Obesity and Liver Iron Content: A Noninvasive Assessment in General Population by Magnetic Resonance Imaging

Central Obesity and Liver Iron Content: A Noninvasive Assessment in General Population by Magnetic Resonance Imaging

Beyond Nutrition Is There Any Role for Physical Activity in Nonalcoholic Fatty Liver Disease Therapy?

Detection of liver metastases in cancer patients with geographic fatty infiltration of the liver: the added value of contrast-enhanced sonography

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