Fatty liver and atherogenic dyslipidemia have opposite effects on diabetic micro- and macrovascular disease

Hermans, Michel P.; Bouénizabila, E.; Amoussou-Guenou, K. Daniel; Gninkoun, Comlan Jules; Ahn, Sylvie A.; Rousseau, Michel F.

doi:10.1016/j.dsx.2022.102613

Cited by 6 publications

(9 citation statements)

References 27 publications

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“… 36 – 40 We also found an association between MAFLD and absence of peripheral arterial disease. The latter is compatible with the paradoxical ocular protection of steatosis in T2DM patients, 41 , 42 as there is an established association between lower-extremity arterial disease and diabetic retinopathy. 43 Moreover, recent data from large cohorts indicate that patients with high visceral fat and low liver fat suffer from higher cardiovascular risk.…”

Section: Discussionsupporting

confidence: 57%

A Cross-sectional Real-life Study of the Prevalence, Severity, and Determinants of Metabolic Dysfunction-associated Fatty Liver Disease in Type 2 Diabetes Patients

Binet¹,

Loumaye²,

Hermans³

et al. 2023

J Clin Transl Hepatol

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Background and Aims Most data on liver assessment in type 2 diabetes mellitus (T2DM) patients are from retrospective cohorts with selection bias. We aimed at appraising the feasibility, results, and benefits of an outpatient systematic noninvasive screening for metabolic dysfunction-associated fatty liver disease (MAFLD) severity and determinants in T2DM patients. Methods We conducted a 50-week cross-sectional study enrolling adult T2DM outpatients from a diabetes clinic. An algorithm based on guidelines was applied using simple bioclinical scores and, if applicable, ultrasound and/or elastometry. Results Two hundred and thirteen patients were included. Mean age and body mass index were 62 years and 31 kg/m 2 and 29% of patients had abnormal transaminase levels. The acceptance rate of additional liver examinations was 92%. The prevalence of MAFLD, advanced fibrosis and cirrhosis was 87%, 11%, and 4%, respectively. More than half of the cases of advanced fibrosis had not been suspected and were detected by this screening. MAFLD was associated with poor glycemic control, elevated transaminases, low HDL-C and the absence of peripheral arterial disease. Advanced fibrosis was linked to high waist circumference and excessive alcohol consumption, which should be interpreted with caution owing to the small number of patients reporting excessive consumption. Conclusions Simple bioclinical tools allowed routine triage of T2DM patients for MAFLD severity, with high adherence of high-risk patients to subsequent noninvasive exams.

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Section: Discussionsupporting

confidence: 57%

A Cross-sectional Real-life Study of the Prevalence, Severity, and Determinants of Metabolic Dysfunction-associated Fatty Liver Disease in Type 2 Diabetes Patients

Binet¹,

Loumaye²,

Hermans³

et al. 2023

J Clin Transl Hepatol

Self Cite

View full text Add to dashboard Cite

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“…The existence of such an interaction pattern can be supported by other studies to some extent, which showed in patients with type 2 diabetes mellitus, those who developed NAFLD had a lower frequency of cataract. 68 , 69 Admittedly, the underlying mechanisms require to be further investigated.…”

Section: Discussionmentioning

confidence: 99%

Associations of severe liver diseases with cataract using data from UK Biobank: a prospective cohort study

Chen,

Wei,

et al. 2024

eClinicalMedicine

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“…Nevertheless, a prospective study of T2DM patients using glucagon-like receptor-I agonists calls for more attention paid on potential side effects of therapeutic strategies, as a protective effect on liver steatosis of NASH was found with aggravated retinopathy simultaneously [ 71 ]. Current and future treatments for liver diseases should guarantee that they would not worsen ophthalmopathy (if existed) and vice versa [ 193 ].…”

Section: Clinical Links and Practical Applicationsmentioning

confidence: 99%

Insights into the liver-eyes connections, from epidemiological, mechanical studies to clinical translation

Wu,

Duan,

Yang

et al. 2023

J Transl Med

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Maintenance of internal homeostasis is a sophisticated process, during which almost all organs get involved. Liver plays a central role in metabolism and involves in endocrine, immunity, detoxification and storage, and therefore it communicates with distant organs through such mechanisms to regulate pathophysiological processes. Dysfunctional liver is often accompanied by pathological phenotypes of distant organs, including the eyes. Many reviews have focused on crosstalk between the liver and gut, the liver and brain, the liver and heart, the liver and kidney, but with no attention paid to the liver and eyes. In this review, we summarized intimate connections between the liver and the eyes from three aspects. Epidemiologically, we suggest liver-related, potential, protective and risk factors for typical eye disease as well as eye indicators connected with liver status. For molecular mechanism aspect, we elaborate their inter-organ crosstalk from metabolism (glucose, lipid, proteins, vitamin, and mineral), detoxification (ammonia and bilirubin), and immunity (complement and inflammation regulation) aspect. In clinical application part, we emphasize the latest advances in utilizing the liver-eye axis in disease diagnosis and therapy, involving artificial intelligence-deep learning-based novel diagnostic tools for detecting liver disease and adeno-associated viral vector-based gene therapy method for curing blinding eye disease. We aim to focus on and provide novel insights into liver and eyes communications and help resolve existed clinically significant issues.

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Fatty liver and atherogenic dyslipidemia have opposite effects on diabetic micro- and macrovascular disease

Cited by 6 publications

References 27 publications

A Cross-sectional Real-life Study of the Prevalence, Severity, and Determinants of Metabolic Dysfunction-associated Fatty Liver Disease in Type 2 Diabetes Patients

A Cross-sectional Real-life Study of the Prevalence, Severity, and Determinants of Metabolic Dysfunction-associated Fatty Liver Disease in Type 2 Diabetes Patients

Associations of severe liver diseases with cataract using data from UK Biobank: a prospective cohort study

Insights into the liver-eyes connections, from epidemiological, mechanical studies to clinical translation

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