Fatty kidney disease: The importance of ectopic fat deposition and the potential value of imaging

Mende, Christian W.; Einhorn, Daniel

doi:10.1111/1753-0407.13232

Cited by 20 publications

(17 citation statements)

References 54 publications

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“…40 The term "fatty kidney," first appearing in the literature in 1883, 41 suggests that hyperlipidemia is the cause of the characteristic renal lipid accumulation and nephrotoxicity. 40 Obesity itself is associated with increased renal tubular sodium reabsorption followed by initial hyperfiltration and a subsequent gradual decline in the estimated glomerular filtration rate. 7 Adipocytes are able to secrete all components of the RAAS and are upregulated in obesity.…”

Section: Discussionmentioning

confidence: 99%

“…39 The probable mechanism of this phenomenon was the association between obesity and fatty kidney disease. 40 The term "fatty kidney," first appearing in the literature in 1883, 41 suggests that hyperlipidemia is the cause of the characteristic renal lipid accumulation and nephrotoxicity. 40 Obesity itself is associated with increased renal tubular sodium reabsorption followed by initial hyperfiltration and a subsequent gradual decline in the estimated glomerular filtration rate.…”

Section: Discussionmentioning

confidence: 99%

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The association of hypertriglyceridemic waist phenotype with hypertension: A cross‐sectional study in a Chinese middle aged‐old population

Xuan

Shen

Wang

et al. 2022

J of Clinical Hypertension

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The present study aimed to evaluate the relationship between the hypertriglyceridemic waist (HTGW) phenotype and hypertension. We undertook a cross-sectional study with a sample of 9015 adults from China. The HTGW phenotype was defined as elevated waist circumference (WC) and elevated triglyceride (TG) concentration.Logistic regression analysis was used to evaluate the association between the HTGW phenotype and hypertension. The prevalence of hypertension was significantly higher in individuals with the HTGW phenotype, than in those with the normal waist normal triglyceride (NWNT) phenotype (89.9% vs 75.3%, respectively, P < .001). After adjusting for age, sex, BMI, current smoker, and current alcohol consumption, the HTGW phenotype was associated with hypertension (Odds Ratio (OR)1.53; 95% CI 1.25-1.87).After further adjustment for potential confounders, the HTGW phenotype was still significantly associated with hypertension (adjusted OR1.28; 95% CI 1.04-1.58) regardless of sex. The subgroup analyses generally revealed similar associations across all subgroups. This study indicated that the HTGW phenotype was strongly associated with hypertension, and blood pressure should be clinically monitored in individuals with the HTGW phenotype. We suggested a combined use of hypertriglyceridemia waist phenotype in identifying participants who are at high risk of hypertension.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The association of hypertriglyceridemic waist phenotype with hypertension: A cross‐sectional study in a Chinese middle aged‐old population

Xuan

Shen

Wang

et al. 2022

J of Clinical Hypertension

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“…50 The other probable mechanism of this phenomenon was the association between obesity and fatty kidney disease. The term "fatty kidney", first named in the literature in 1883, 51 suggests that hyperlipidemia is the cause of renal lipid accumulation and nephrotoxicity. 52 Obesity is correlated with initial hyperfiltration leading to elevated renal tubular sodium reabsorption and a subsequent gradual decline in the estimated glomerular filtration rate.…”

Section: Discussionmentioning

confidence: 99%

The Association Between Hypertriglyceridemic-Waist Phenotype and Chronic Kidney Disease in Patients with Type 2 Diabetes: A Cross-Sectional METAL Study

Xuan¹,

Zhang²,

Wang³

et al. 2022

DMSO

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The aim of this study was measuring the association between the hypertriglyceridemic-waist (HTGW) phenotype and chronic kidney disease in a large type 2 diabetes population. Methods: A total of 4254 diabetic patients from the cross-sectional Environmental Pollutant Exposure and Metabolic Diseases in Shanghai (METAL) study were enrolled. The hypertriglyceridemic-waist (HTGW) phenotype was defined as the presence of an elevated waist circumference (WC) and elevated triglyceride (TG) concentration. Chronic kidney disease (CKD) was defined as an estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 m 2 or urinary albumin creatinine ratio (uACR) more than 30 mg/g. Linear and multiple logistic regression models were used for measuring the association between HTGW phenotype and chronic kidney disease. Results: The prevalence of CKD was 29% and 35.8% in total participants and participants with HTGW phenotype, respectively. Subjects in the HTGW phenotype group were more likely to have CKD (OR 1.47, 95% CI: 1.11, 1.95) compared with subjects in the normal waist circumference and normal triglycerides (NTNW) group. HTGW phenotype was both associated with the increasing risk of decreased eGFR (OR 1.31, 95% CI: 1.02, 1.75) and elevated uACR (OR 1.57, 95% CI: 1.18, 2.11). Furthermore, the stratified analysis showed that the strongest positive association between HTGW phenotype and CKD presence was found in the subgroup of presence of hypertension. The associations were all fully adjusted for age, sex, BMI, current smoking, current drinking and other confounding factors. Conclusion:Our study suggested a positive association between the HTGW phenotype and CKD in Chinese type 2 diabetes patients. Further prospective studies are needed to confirm our findings and to investigate the underlying biological mechanisms.

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“…Patients with FRPM-high had significantly lower eGFR level than those with FRPM-low. Ectopic fat accumulation in the skeletal muscle may be linked to ectopic fat accumulation in the kidney, causing lower eGFR 31 . Older age in patients with FRPM-high can cause lower eGFR.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Impact of Ectopic Fat Deposition within Psoas Muscle in Stage IV Gastric Cancer Patients Undergoing Systemic Chemotherapy

Ikegami¹,

Nishikawa²,

Goto³

et al. 2022

J. Cancer

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Aims: In this study, we focused on the fat ratio within psoas muscle (FRPM) and sought to clarify the impact of FRPM on overall survival (OS) in stage IV gastric cancer (GC) patients undergoing systemic chemotherapy ( n = 79, median age = 69 years, 59 males). Methods: The median FRPM was 1.67 %. Forty patients with FRPM ≥1.67 % were defined as the FRPM-high group, and the remaining 39 patients was defined as the FRPM-low group. The median PMI in male and female patients was 4.35 cm 2 /m 2 and 2.88 cm 2 /m 2 . Thirty male patients with PMI ≥4.35 cm 2 /m 2 and 10 female patients with PMI ≥2.88 cm 2 /m 2 was defined as the PMI-high group, and the remaining 39 patients was defined as the PMI-low group. Results: The 1-, 2- and 3- year cumulative OS rate for all cases was 70.8%, 24.3% and 14.6%. The proportion of ECOG-PS 2 or 3 in patients with FRPM-high and FRPM-low was 17.5% (7/40) and 2.6% (1/39). The 1-, 2- and 3- year cumulative OS rate in patients with FRPM-high and FRPM-low was 67.3%, 14.3% and 7.6% in the FRPM-high group and 74.8%, 40.5% and 32.4% in the FRPM-low group ( P = 0.0341). The 1-, 2- and 3- year cumulative OS rate in patients with PMI-high and PMI-low was 86.7%, 40.4% and 30.0% in the PMI-high group and 55.8%, 12.8% and 6.4% in the PMI-low group ( P < 0.0001). In the multivariate analysis of factors associated with OS, PMI ( P = 0.0047) and FRPM ( P = 0.0019) were independent predictors for the OS. Conclusion: Higher FRPM can be associated with decreased physical activity, and not only skeletal muscle mass but also skeletal muscle function can be an essential prognostic factor in stage IV GC patients undergoing systemic chemotherapy.

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Fatty kidney disease: The importance of ectopic fat deposition and the potential value of imaging

Cited by 20 publications

References 54 publications

The association of hypertriglyceridemic waist phenotype with hypertension: A cross‐sectional study in a Chinese middle aged‐old population

The association of hypertriglyceridemic waist phenotype with hypertension: A cross‐sectional study in a Chinese middle aged‐old population

The Association Between Hypertriglyceridemic-Waist Phenotype and Chronic Kidney Disease in Patients with Type 2 Diabetes: A Cross-Sectional METAL Study

Prognostic Impact of Ectopic Fat Deposition within Psoas Muscle in Stage IV Gastric Cancer Patients Undergoing Systemic Chemotherapy

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