Fatty infiltration of the liver: quantification with phase-contrast MR imaging at 1.5 T vs biopsy.

Levenson, H; Greensite, Fred; Hoefs, John C.; Friloux, L.; Applegate, Gregory R.; Silva, E; Kanel, Gary C.; Buxton, Richard B.

doi:10.2214/ajr.156.2.1898804

Cited by 165 publications

(112 citation statements)

References 3 publications

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“…29 Although new MRI techniques have resulted in considerable improvement in detecting steatosis, these methods measure hepatic fat indirectly, and thus, the majority of comparative studies have used biopsy results. [30][31][32][33] Due to the above-mentioned disadvantages and insensitivities of imaging-based modalities, we used liver biopsy results to diagnose hepatic steatosis. It should be noted that liver biopsies have limitations, for example sampling error in the case of inhomogeneous fat distribution and variability of interpretation, 34,35 however, liver biopsies uniquely provide a direct measure of hepatic steatosis, and have sensitivity and specificity advantages over imaging studies.…”

Section: Discussionmentioning

confidence: 99%

Visceral adipose tissue area is an independent risk factor for hepatic steatosis

Park

Kim

et al. 2007

J of Gastro and Hepatol

144

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Background and Aim: Recent data indicate that hepatic steatosis is associated with insulin resistance, dyslipidemia and obesity (especially central body fat distribution). There have been few studies on the correlation between biopsy-proven hepatic steatosis and the above factors in a disease-free population. The aim of the present study was to evaluate the relation between hepatic steatosis assessed by biopsy and clinical characteristics including regional fat distribution measured by computed tomography (CT) in living liver donors. Methods: Laboratory data, liver/spleen Hounsfield ratio (L/S ratio), regional fat distribution by CT and liver status by biopsy were evaluated retrospectively in a total of 177 living liver donors without a history of alcohol intake. Results: The unpaired t-test showed that age, triglycerides (TG), high density lipoprotein, total cholesterol, alanine aminotransferase, body mass index, L/S ratio, visceral adipose tissue area (VAT) and subcutaneous adipose tissue area (SAT) were associated with hepatic steatosis. In the multiple logistic regression analysis, VAT (odds ratio 1.031, 95% CI 1.013-1.048, P < 0.01) and TG (odds ratio 1.012, 95% CI 1.004-1.020, P < 0.01) were independent risk factors of hepatic steatosis. Subgroup analysis also showed that VAT was an independent risk factor in men (odds ratio 1.022, 95% CI 1.003-1.041, P < 0.05) and women (odds ratio 1.086, 95% CI 1.010-1.168, P < 0.05). Conclusion: Our results suggest that visceral abdominal adiposity is correlated with hepatic steatosis in healthy living liver donors.

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Section: Discussionmentioning

confidence: 99%

Visceral adipose tissue area is an independent risk factor for hepatic steatosis

Park

Kim

et al. 2007

J of Gastro and Hepatol

144

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“…With the use of modern scanners and fast imaging sequences, such as dualecho chemical shift GRE imaging, the effects of magnetic field inhomogeneities are reduced, thereby allowing more accurate and easier quantification of liver fat (3)(4)(5). Quantification of hepatic fat fraction (HFF) from out-and in-phase MR images is a reliable method, and the HFF values correlate highly with histological liver fat fractions (4,6,7).…”

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confidence: 99%

Diffusion‐weighted MRI of fatty liver

Poyraz

Onur

Kocakoç

et al. 2011

Magnetic Resonance Imaging

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Purpose: To investigate the effect of fat infiltration on the apparent diffusion coefficient (ADC) of liver, and assess the relationship between ADC and hepatic fat fraction (HFF).Materials and Methods: MRI scans of 120 consecutive patients were included in this retrospective study. Of these, 42 patients were included in the fatty liver group and 78 in the control group. ADC values were measured from a pair of diffusion-weighted (DW) images (b ¼ 0 mm 2 /s and 1000 mm 2 /s). HFFs were measured using T1W GRE dual-echo images. The difference between the ADCs of the two groups was assessed with the t-test. The relationship between HFF and ADC was determined using linear regression analysis and the Pearson correlation coefficient (r).Results: Mean HFFs were 0.85 6 2.86 and 13.67 6 8.62 in the control and fatty liver groups, respectively. The mean ADC of fatty liver group 1.20 6 0.22 Â 10 À3 mm 2 /s was significantly lower than that of the control group 1.32 6 0.23 Â 10 À3 mm 2 /s (P ¼ 0.02). Linear regression analysis revealed an inverse relationship between ADC and HFF (r ¼ À0.39, P < 0.0001).Conclusion: ADC significantly decreases in patients with >5% HFF, and ADC and HFF exhibit an inverse relationship.

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“…Liver steatosis is linked to obesity because, in obese subjects, visceral fat functions as an endocrine organ by producing inflammatory mediators that interfere with hepatic glucose metabolism and cause insulin resistance and liver steatosis (1,5,6). Some studies (7)(8)(9)(10) have investigated the ability of magnetic resonance (MR) imaging to help detect liver steatosis in patients with diffuse liver disease. Clinically calculated body mass index (BMI) (patient's body weight divided by the square of his or her height) has often been used as a surrogate anthropometric marker of obesity-related morbidity, even though this measurement does not account for body tissue composition or distribution of body fat.…”

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confidence: 99%

Liver Steatosis: Investigation of Opposed-Phase T1-weighted Liver MR Signal Intensity Loss and Visceral Fat Measurement as Biomarkers

Bahl¹,

Qayyum²,

Westphalen³

et al. 2008

Radiology

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Purpose:To investigate if opposed-phase T1-weighted and fat-suppressed T2-weighted liver signal intensity (SI) loss and visceral fat measurement at magnetic resonance (MR) imaging and body mass index (BMI) are correlated with grade of liver steatosis in patients with nonalcoholic fatty liver disease (NAFLD) or hepatitis C virus (HCV) and human immunodeficiency virus (HIV)-related liver disease. Materials and Methods:Committee on Human Research approval and patient consent were obtained for this HIPAA-compliant study. Fiftytwo patients (15 men, 37 women) with NAFLD (n ϭ 29) or HCV and HIV-related liver disease (n ϭ 23) underwent prospective contemporaneous MR imaging and liver biopsy. Liver SI loss was measured on opposed-phase T1-weighted and fat-suppressed T2-weighted MR images. Visceral fat area was measured at three levels on watersuppressed T1-weighted MR images (n ϭ 44). Spearman rank correlation coefficients and recursive partitioning were used to examine correlations. Results:Histopathologic liver steatosis correlated well with liver SI loss on opposed-phase T1-weighted MR images ( ϭ 0.78), fat-suppressed T2-weighted MR images ( ϭ 0.75), and average visceral fat area ( ϭ 0.77) (all P Ͻ .01) but poorly with BMI ( ϭ 0.53, P Ͻ .01). Liver SI losses on opposed-phase T1-weighted MR imaging of less than 3%, at least 3% but less than 35%, at least 35% but less than 49%, and at least 49% corresponded to histopathologic steatosis grades of 0 (n ϭ 16 of 17), 1 (n ϭ 11 of 16), 2 (n ϭ 7 of 13), and 3 (n ϭ 5 of 6), respectively. A visceral fat area of greater than or equal to 73.8 cm 2 was associated with the presence of histopathologic steatosis in 41 of 44 patients.

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Fatty infiltration of the liver: quantification with phase-contrast MR imaging at 1.5 T vs biopsy.

Abstract: Quantificationof hepatic fat content by application of MR phase-contrast imaging (Dixon method) at 1.

Cited by 165 publications

References 3 publications

Visceral adipose tissue area is an independent risk factor for hepatic steatosis

Visceral adipose tissue area is an independent risk factor for hepatic steatosis

Diffusion‐weighted MRI of fatty liver

Liver Steatosis: Investigation of Opposed-Phase T1-weighted Liver MR Signal Intensity Loss and Visceral Fat Measurement as Biomarkers

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