Fatty acids and plasma antioxidants in HIV-positive patients: Correlation with nutritional and immunological status

Constans, J.; Peuchant, Evelyne; Pellegrin, J.L.; Sergeant, Claire; Hamon, C.; Dubourg, Liliane; Thomas, MF; Simonoff, M.; Pellegrin, Isabelle; Brossard, G.; Barbeau, Pierre-Andre; Fleury, Hervé; Clerc, M; Leng, B; Conri, C.

doi:10.1016/0009-9120(95)00017-4

Cited by 33 publications

(22 citation statements)

References 15 publications

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“…In view of in vitro evidence of altered expression of genes involved in lipid metabolism and fatty acid profiles of HIV-infected cells [24, 22, 23, 20, 21], of clinical evidence of disturbed plasma and tissue lipid concentrations in antiretroviral-naive HIV-1-infected patients [4, 13, 8, 14, 15, 9, 10, 16, 12], and of an increased plasma unesterified AA concentration and brain AA metabolism in 7–9 month old HIV-1 Tg rats [31], we hypothesized that lipid concentrations in different organs and plasma will be altered in drug-free HIV-1 Tg rats compared to wildtype controls. To test this hypothesis, in the present study we measured concentrations of different lipids (including fatty acids) in liver, plasma, heart and brain of 7–9 month old wildtype and HIV-1 Tg rats fed a polyunsaturated fatty acid (PUFA)-sufficient diet free of AA and docosahexaenoic acid (DHA, 22:6n-3) [31, 32].…”

Section: Introductionmentioning

confidence: 99%

Altered lipid concentrations of liver, heart and plasma but not brain in HIV-1 transgenic rats

Taha

Basselin

Ramadan

et al. 2012

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Section: Introductionmentioning

confidence: 99%

Altered lipid concentrations of liver, heart and plasma but not brain in HIV-1 transgenic rats

Taha

Basselin

Ramadan

et al. 2012

Prostaglandins, Leukotrienes and Essential Fatty Acids

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“…The results of this study suggest that there may be. The results indicated that an 'affluent, Western' type of diet, different from the prudent diet recommended for optimal health 21,27 , is positively associated with metabolic variables known to decrease in HIV-infected subjects proportionally to disease stage 12,25 . Urgent research is necessary for a better understanding of the early metabolic effects of HIV and ways that diet can be used to reduce the impact of HIV infection on health.…”

Section: Discussionmentioning

confidence: 96%

“…As for serum albumin 12 , there appears to be an association between disease stage and serum cholesterol level 25 . The decrease in cholesterol of the HIV-infected subjects was accompanied by a decrease in HDL-cholesterol.…”

Section: Discussionmentioning

confidence: 99%

The nutritional status of asymptomatic HIV-infected Africans: directions for dietary intervention?

Vorster

Kruger

Margetts

et al. 2004

Public Health Nutr.

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Objective: To compare the relationships between food (nutrient) intakes and biochemical markers of nutritional status of asymptomatic HIV-infected with HIVuninfected subjects, to gain more information on the appropriate diet for HIV-infected persons at an early stage of infection. Design: Cross-sectional population-based survey. Setting: North West Province, South Africa. Subjects: Two hundred and sixteen asymptomatic HIV-infected and 1550 HIVuninfected men and women volunteers aged 15 years and older, recruited as 'apparently healthy' subjects from 37 randomly selected sites. Outcome measures: Food and nutrient intakes, measured with a validated foodfrequency questionnaire, and nutritional status indicated by anthropometric and biochemical variables, measured by a standardised methodology. Results: The prevalence of HIV infection in the study population was 11.9%. The anthropometric indices and nutrient intakes of HIV-infected and uninfected subjects did not differ significantly, indicating that these 216 HIV-infected subjects were at an early stage of infection. Of the biochemical nutritional status variables, high-density lipoprotein cholesterol and total cholesterol, haemoglobin, albumin and triglycerides were significantly lower in infected subjects. They also had higher globulin and liver enzyme levels than uninfected subjects. In infected subjects, serum albumin correlated significantly with serum lipids, serum vitamin A, serum vitamin E, serum iron, total iron-binding capacity and haemoglobin. The significant positive correlations of the liver enzymes with serum lipids, albumin, vitamin A and iron, observed in HIV-uninfected subjects, disappeared in the infected subjects. Polyunsaturated fat intake showed significant positive correlations with the increased liver enzymes in infected subjects. A principal components analysis indicated that, in infected subjects, increased liver enzymes correlated with higher consumption of maize meal and lower consumption of meat and vegetables. Conclusions and recommendations: This survey indicated that asymptomatic HIVinfected subjects who followed a diet rich in animal foods had smaller decreases in serum albumin, haemoglobin and lipid variables, and smaller increases in liver enzymes, than those who consumed a diet based on staple foods. This suggests that animal foods are associated with improved nutritional status in HIV-infected persons. These results should be confirmed with intervention studies before dietary recommendations for asymptomatic HIV-infected individuals can be made.

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“…Low serum vitamin E levels in HIV-1-infected individuals prior to the ART era have been correlated with a higher degree of lipid peroxidation [177], increased p24 antigenemia [178], decreased plasma levels of polyunsaturated fatty acids and increased plasma immunogloblin IgE levels [179]. In an observational study prior to ART, Tang and colleagues found that in a cohort of 312 HIV-infected men, those in the highest quartile of serum vitamin E levels (≥23.5 µmol/l) showed a 34% decrease in risk of progression to AIDS compared with those in the lowest quartile (relative hazard [RH]: 0.66; 95% CI: 0.41-1.06) [46].…”

Section: Vitamin Ementioning

confidence: 99%

Micronutrients and HIV Infection

Campa

Baum²

2010

HIV Ther.

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The immune system requires several essential micronutrients to maintain an effective immune response. HIV infection destroys the immune system and promotes nutritional deficiencies, which further impair immunity. This article reviews the role of several micronutrients (vitamins A, C, E and D, the B vitamins, and minerals, selenium, iron and zinc) that are relevant for maintaining immune function. In addition, the deficiencies of these micronutrients have been associated with faster progression of HIV-1 disease. This review examines the evidence from observational studies of an association between micronutrient status and HIV disease, as well as the effectiveness of micronutrient supplementation on HIV-disease progression, pregnancy outcomes and nutritional status, among others, utilizing randomized clinical trials. Each micronutrient is introduced with a summary of its functions in human physiology, followed by the presentation of studies conducted in HIV-infected patients in relation to this specific micronutrient. Overall findings and recommendations are then summarized.

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Fatty acids and plasma antioxidants in HIV-positive patients: Correlation with nutritional and immunological status

Cited by 33 publications

References 15 publications

Altered lipid concentrations of liver, heart and plasma but not brain in HIV-1 transgenic rats

Altered lipid concentrations of liver, heart and plasma but not brain in HIV-1 transgenic rats

The nutritional status of asymptomatic HIV-infected Africans: directions for dietary intervention?

Micronutrients and HIV Infection

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