Fatty acids and oxidative stress in psychiatric disorders

Tsaluchidu, Sofia; Cocchi, Massimo; Tonello, Lucio; Puri, Basant K.

doi:10.1186/1471-244x-8-s1-s5

Cited by 119 publications

(60 citation statements)

References 5 publications

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“…In studies that examined the impact of Montmorency tart cherry juice supplementation on exercise-induced inflammation, tart cherry juice attenuated circulating inflammatory markers and increased the antioxidant capacity of cyclists and marathon runners (58,59). Because patients with sleep and psychiatric disorders exhibit increased levels of oxidative stress (60), the abundance of antioxidants in cherries may mediate improvements in sleep quality by minimizing oxidative damage.…”

Section: Sleep-promoting Foods and Sleep Quality: Experimental Findingsmentioning

confidence: 99%

“…Kiwifruit is a good source of vitamins C and E (46), both of which protect against the damaging effects of free radicals, and is a source of folate. Previous studies reported an association between disordered sleep and oxidative stress (60), and folate deficiency has been linked to insomnia and restless leg syndrome (61). Folic acid supplementation has been shown to alleviate these symptoms (62).…”

Section: Sleep-promoting Foods and Sleep Quality: Experimental Findingsmentioning

confidence: 99%

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Effects of Diet on Sleep Quality

St‐Onge

Mikic

Pietrolungo

2016

Advances in Nutrition

365

300

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There is much emerging information surrounding the impact of sleep duration and quality on food choice and consumption in both children and adults. However, less attention has been paid to the effects of dietary patterns and specific foods on nighttime sleep. Early studies have shown that certain dietary patterns may affect not only daytime alertness but also nighttime sleep. In this review, we surveyed the literature to describe the role of food consumption on sleep. Research has focused on the effects of mixed meal patterns, such as high-carbohydrate plus lowfat or low-carbohydrate diets, over the short term on sleep. Such studies highlight a potential effect of macronutrient intakes on sleep variables, particularly alterations in slow wave sleep and rapid eye movement sleep with changes in carbohydrate and fat intakes. Other studies instead examined the intake of specific foods, consumed at a fixed time relative to sleep, on sleep architecture and quality. Those foods, specifically milk, fatty fish, tart cherry juice, and kiwifruit, are reviewed here. Studies provide some evidence for a role of certain dietary patterns and foods in the promotion of high-quality sleep, but more studies are necessary to confirm those preliminary findings. Adv Nutr 2016;7:938-49.

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Section: Sleep-promoting Foods and Sleep Quality: Experimental Findingsmentioning

confidence: 99%

Section: Sleep-promoting Foods and Sleep Quality: Experimental Findingsmentioning

confidence: 99%

Effects of Diet on Sleep Quality

St‐Onge

Mikic

Pietrolungo

2016

Advances in Nutrition

365

300

View full text Add to dashboard Cite

show abstract

“…Apesar da etiologia incerta da esquizofrenia, evidências apontam para um metabolismo anormal dos fosfolipídios, particularmente na composição dos ácidos graxos das membranas celulares [14][15][16][17][18][19] . Nesse contexto, estudos revelaram que pacientes esquizofrênicos apresentam níveis reduzidos de ácidos graxos de cadeia longa nas membranas dos eritrócitos, provavelmente por causa de atividade excessiva de uma fosfolipase A 2 20,21 .…”

Section: Introductionunclassified

Ácidos graxos ômega 3 e tratamento da esquizofrenia

Zemdegs¹,

Pimentel²,

Priel³

2010

Rev. psiquiatr. clín.

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ResumoContexto: A esquizofrenia é uma desordem psiquiátrica complexa e debilitante cujo tratamento de base é realizado com medicamentos antipsicóticos. No entanto, evidências sugerem que a suplementação dietética com ácidos graxos ômega 3 (n-3) pode ser benéfica em diversas desordens psiquiátricas. Objetivo: Revisar a eficácia do n-3 como coadjuvante no tratamento farmacológico da esquizofrenia. Métodos: Realizou-se uma pesquisa nas bases de dados eletrônicas Medline, Lilacs e SciELO. A estratégia de busca também incluiu a busca em árvore. Todos os estudos randomizados e controlados relevantes foram incluídos nesta revisão, independentemente do ano de publicação. Resultados: Até o momento, foram divulgados seis estudos randomizados, duplo-cegos placebo controlados; cinco deles apresentaram resultados positivos na melhora dos sintomas da esquizofrenia, assinalando, ainda, superioridade do ácido graxo eicosapentaenoico (EPA) em relação ao ácido graxo docosaexaenoico. Em geral, o consumo de 2 g/dia de EPA conjuntamente com a medicação antipsicótica usual parece reduzir a sintomatologia da esquizofrenia, particularmente os sintomas positivos. Conclusão: A terapia nutricional com EPA mostrou-se útil como coadjuvante no tratamento da esquizofrenia. Por conseguinte, sugere-se que os pacientes esquizofrênicos sejam encorajados a consumir refeições balanceadas e saudáveis ricas em EPA e, caso a quantidade ideal não seja atingida pela dieta, a suplementação pode ser benéfica. Zemdegs JCS, et al. / Rev Psiq Clín. 2010;37(5):223-7Palavras-chave: Esquizofrenia, nutrição, ácido eicosapentaenoico, ácido graxo ômega 3, tratamento. AbstractBackground: Schizophrenia is a complex and debilitating psychiatric disorder, whose primary pharmacological intervention is the use of antipsychotics. There is, however, growing evidence that dietary supplementation with omega 3 fatty acids (n-3) may be beneficial in several psychiatric conditions. Objective: To review the efficacy of n-3 as a treatment for schizophrenia. Methods: Electronic searches of the following databases were performed: Medline, Lilacs e SciELO. The search strategy also included cited reference searching. All relevant randomized controlled trials were included in the review. Results: To date, five out of six randomized, double-blind, and placebo controlled studies obtained improvement in the symptoms of the psychosis. Besides, an advantage in the intake of eicosapentaenoic fatty acid (EPA) in relation to docosahexaenoic fatty acid was designated. Essentially, the intake of 2 g/day of EPA in addition to the standard medication was effective in decreasing the symptoms of schizophrenia. Discussion: The nutritional therapy with EPA revealed to be useful as coadjutant in the treatment of schizophrenia. Therefore, we suggest that the schizophrenic patients should be encouraged to consume balanced and healthy meals rich in EPA and, if the ideal amount is not reached by the diet, the supplementation is likely to be beneficial.

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“…The participants underwent a medical examination and blood sampling. Serum TOS, TAC, estrogen, progesterone, and PON-1 levels were assessed during the luteal (days [21][22][23][24][25] and follicular (days 6-8) phases of 2 consecutive menstrual cycles in all 50 subjects. Ovulation was determined by evaluating plasma progesterone levels on day 21 (the subject was considered to be ovulating when plasma progesterone levels were ≥10.0 ng/ mL).…”

Section: Procedures and Participantsmentioning

confidence: 99%

“…Measuring the total antioxidant capacity (TAC) requires the simultaneous quantification of several antioxidant markers and is one indicator of oxidative status [5]. Oxidative stress may lead to premature cell death and is associated with many ischemic and inflammatory diseases, degenerative disorders, and psychiatric disorders such as depression, bipolar disorder, schizophrenia, obsessive compulsive disorder, sleep disorders, and anxiety disorders [18][19][20][21][22][23]. In addition, almost all steps of inflammation and cellular immune activation have been linked to depression pathogenesis [24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Total oxidant–antioxidant and paraoxonase-1 levels in premenstrual dysphoric disorder: a follow-up study

Özcan

Oral

Güleç

et al. 2017

Psychiatry and Clinical Psychopharmacology

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Objective: Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome (PMS) that was categorized as a mood disorder in the most recent version of the Diagnostic and Statistical Manual for Mental Disorders. In addition to a history of PMS, a PMDD diagnosis requires prospective symptom assessment for 2 consecutive menstrual periods. Although the effects of some oxidants-antioxidants were previously studied in PMS, their possible effects in PMDD remain unknown. Paraoxonase-1 (PON-1) is a new high-density lipoproteinassociated enzyme with many antioxidative effects. We hypothesized that assessing serum total oxidant-antioxidant and PON-1 levels could clarify the role of oxidant-antioxidant system in PMDD. Methods: All participants (n = 50) were assessed by an experienced psychiatrist for PMDD by using the Diagnostic and Statistical Manual for Mental Disorders-IV (DSM-IV), Premenstrual Assessment Form and Daily Record of Severity of Problems (DRSP)-Short Form or possible psychiatric disorders including depression, anxiety, and sleep disorders. Serum estrogen, progesterone, total oxidant-antioxidant, and paraoxonase-1 (PON-1) levels were measured in the serum of 20 participants with PMDD and 30 asymptomatic controls during the follicular and luteal phases of two consecutive menstrual cycles. Sleep quality, depression, and anxiety symptoms were assessed with the Pittsburg Sleep Quality Index (PSQI), Hamilton Depression Rating Scale (HDRS), and Hamilton Anxiety Rating Scale (HARS), respectively. Results: There were no significant intergroup differences in estrogen, progesterone, oxidantantioxidant, or PON-1 levels or PSQI scores. However, the mean HDRS and HARS scores were statistically significantly higher for patients with PMDD than for controls. Levels of estrogen, progesterone, and total oxidant-antioxidant were not correlated with HDRS, HARS, or PSQI scores. Conclusions: Considering the lack of differences in hormonal and biochemical levels between the two groups, it may be more efficient and discriminative to longitudinally assess biochemical and cellular stress-related parameters in subjects with PMDD. ARTICLE HISTORY

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Fatty acids and oxidative stress in psychiatric disorders

Abstract: Background: The aim of this study was to determine whether there is published evidence for increased oxidative stress in neuropsychiatric disorders.

Cited by 119 publications

References 5 publications

Effects of Diet on Sleep Quality

Effects of Diet on Sleep Quality

Ácidos graxos ômega 3 e tratamento da esquizofrenia

Total oxidant–antioxidant and paraoxonase-1 levels in premenstrual dysphoric disorder: a follow-up study

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