Fatty Acids and Complex Lipids

Asselineau, C; Asselineau, J.

doi:10.1007/978-1-4684-4526-8_4

Cited by 16 publications

(10 citation statements)

References 131 publications

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“…2) [18,19]. The stereochemistry of the β-hydroxy-acid fragment was assigned as R,R [20,21]. In addition, it was shown that the cyclopropane units present in α-MA, methoxy-MA or keto-MA could either have cis-stereochemistry as in (4) or α-methyl-trans-cyclopropane stereochemistry as in (5), with the methyl substituent on the distal side of the cyclopropane from the hydroxy-acid [22,23].…”

Section: Structural Properties Of Mycolic Acids Of Mycobacterium Specmentioning

confidence: 99%

Towards understanding the functional diversity of cell wall mycolic acids of Mycobacterium tuberculosis

Verschoor

Baird

Grooten

2012

Progress in Lipid Research

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Mycolic acids constitute the waxy layer of the outer cell wall of Mycobacterium spp and a few other genera. They are diverse in structure, providing a unique chromatographic foot-print for almost each of the more than seventy Mycobacterium species. Although mainly esterified to cell wall arabinogalactan, trehalose or glucose, some free mycolic acid is secreted during in vitro growth of M. tuberculosis. In M. tuberculosis, alpha-, keto-and methoxy-mycolic acids are the main classes, each differing in their ability to attract neutrophils, induce foamy macrophages or adopt an antigenic structure for antibody recognition. Of interest is their particular relationship to cholesterol, discovered by their ability to attract cholesterol, to bind Amphotericin B or to be recognised by monoclonal antibodies that cross-react with cholesterol. The structural elements that determine this diverse functionality include the carboxylic acid in the mycolic motif, as well as the nature and stereochemistry of the two functional groups in the merochain. The functional diversity of mycolic acid classes implies that much information may be contained in the selective expression and secretion of mycolic acids to establish tuberculosis after infection of the host. Their cholesteroid nature may relate to how they utilize host cholesterol for their persistent survival.

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Section: Structural Properties Of Mycolic Acids Of Mycobacterium Specmentioning

confidence: 99%

Towards understanding the functional diversity of cell wall mycolic acids of Mycobacterium tuberculosis

Verschoor

Baird

Grooten

2012

Progress in Lipid Research

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“…5 Furthermore, "You Tides" confirms Asselineau's remark that Whitman's best work often grew out of prose entries in his notebook. 6 Two entries in Specimen Days, "A Winter Day on the Sea-Beach" and "Sea-Shore Fancies," bear close resemblance to the poem, and appear to have given rise to the entire "Fancies at Navesink" cluster.…”

Section: Iumentioning

confidence: 76%

"You Tides with Ceaseless Swell": A Reading of the Manuscript

Sill¹

1989

Walt Whitman Quarterly Review

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“…The most likely interpretation of these data was that the even C homologues were isoand n-isomers, while the odd C homologues were anteisoand, possibly, n-isomers, based on their expected chromatographic behaviour. In the MS of the methyl esters of anteiso-acids the intensity of the [M-29]+ ion (loss of CZHJ is greater than that of the [M-31]+ ion (loss of OCH,) and this is considered as diagnostic of their presence (Asselineau and Asselineau, 1984;Christie, 1989). Ions at [M-60]+, [M-61]+ and [M-79]+ are also of diagnostic value (Christie, 1989).…”

Section: Results a N D Discgsionmentioning

confidence: 99%

Compositional analysis of intact alkyl esters in leaf epicuticular wax of swede by capillary gas chromatography and electron‐impact mass spectrometry

Shepherd¹,

Robertson²,

Griffiths³

1995

Phytochemical Analysis

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A method for the separation and identification of complex mixtures of more than 50 different intact esters in epicuticular wax of swede, Brassica napus var. rapifera cv. Doon Major, using combined gas chromatography‐mass spectrometry (GC‐MS) has been developed. The esters were separated at temperatures of up to 350°C by automatic pressure programming (for capillary GC) or by manually increasing helium carrier gas pressure (for GC‐MS) in order to maintain flow at high temperatures. Esters in the range C41‐C50 were detected, with regular repeating acid/alcohol combinations. Individual acid and alcohol moieties were identified from [RCO2H2]+ ions in the mass spectra of intact esters and, following trans‐esterification and silylation, from the mass spectral and chromatographic characteristics of the methyl esters of the acid components (C14‐C23) and trimethylsilyl derivatives of the alcohol components (C23‐C31). The major compounds were doubly branched C44 and C46 esters, composed of anteiso‐C17/anteiso‐C27 (32.7%), anteiso‐C17/anteiso‐C29 (11.9%) and anteiso‐C19/anteiso‐C27 (13.1%) acid/alcohol combinations, respectively, singly branched C43 and C45 esters, composed of n‐C16/anteiso‐C27 (8.5%), anteiso‐C17/n‐C26 (3.9%), n‐C18/anteiso‐C27 (6.8%), anteiso‐C17/n‐C28 (2.3%) and anteiso‐C19/n‐C26 (1.6%), were minor components.

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Fatty Acids and Complex Lipids

Cited by 16 publications

References 131 publications

Towards understanding the functional diversity of cell wall mycolic acids of Mycobacterium tuberculosis

Towards understanding the functional diversity of cell wall mycolic acids of Mycobacterium tuberculosis

"You Tides with Ceaseless Swell": A Reading of the Manuscript

Compositional analysis of intact alkyl esters in leaf epicuticular wax of swede by capillary gas chromatography and electron‐impact mass spectrometry

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