Fatty acid translocase gene CD36 rs1527483 variant influences oral fat perception in Malaysian subjects

Ong, Hing-Huat; Tan, Yen Nee; Say, Yee‐How

doi:10.1016/j.physbeh.2016.11.006

Cited by 17 publications

(32 citation statements)

References 41 publications

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“…Additionally, the small cohort size may have resulted in an amplification of the effects of the rs1761667 SNP; albeit, the MAFs observed in our Caucasian participants agree with population norms (dnSNP Short Genetic Variations, 2017) and values reported by Ong et al. () for Malaysians of Chinese descent. Small sample sizes in several of the genotype groups strongly justifies repeating this study in a larger cohort to verify the current findings.…”

Section: Discussionsupporting

confidence: 85%

“…As a limitation, we did not assess individual variation in lingual lipase activity (Kulkarni & Mattes, 2014) that could influence the availability of fatty acids to interact with oral fat receptors to enhance fat perception. Additionally, the small cohort size may have resulted in an amplification of the effects of the rs1761667 SNP; albeit, the MAFs observed in our Caucasian participants agree with population norms (dnSNP Short Genetic Variations, 2017) and values reported by Ong et al (2017) for Malaysians of Chinese descent. Small sample sizes in several of the genotype groups strongly justifies repeating this study in a larger cohort to verify the current findings.…”

Section: Sensory and Food Qualitysupporting

confidence: 74%

“…When Ong et al. () examined the rs1527483 SNP in a Malaysian population of predominantly Chinese descent, they found similarly that participants who were homozygous for the T allele perceived more fat in both regular and reduced‐fat cream crackers. However, no robust relationships were observed between the rs1761667 SNP and fat perception in this latter investigation.…”

Section: Discussionmentioning

confidence: 99%

“…Presumably, if SNPs in CD36 play a substantial role in altering oral fat perception, then the presence of such alleles could heighten the risk of excess fat consumption, which may lead to weight gain. Previous studies examining fat taste responsiveness by CD36 genotype have been conducted predominantly in overweight/obese cohorts of African Americans (Keller et al., ; Pepino, Finkbeiner, Beauchamp, & Mennella, ), Tunisian women (Mrizak et al., ), or Malaysians (Ong, Tan, & Say, ). Only one investigation in Italy assessed individuals with healthy body weights (Melis et al., ).…”

Section: Introductionmentioning

confidence: 99%

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Effects of CD36 Genotype on Oral Perception of Oleic Acid Supplemented Safflower Oil Emulsions in Two Ethnic Groups: A Preliminary Study

Burgess

Melis

Scoular

et al. 2018

Journal of Food Science

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Previous studies demonstrate humans can detect fatty acids via specialized sensors on the tongue, such as the CD36 receptor. Genetic variation at the common single nucleotide polymorphism rs1761667 of CD36 has been shown to differentially impact the perception of fatty acids, but comparative data among different ethnic groups are lacking. In a small cohort of Caucasian and East Asian young adults, we investigated if: (1) participants could detect oleic acid (C18:1) added to safflower oil emulsions at a constant ratio of 3% (w/v); (2) supplementation of oleic acid to safflower oil emulsions enhanced perception of fattiness and creaminess; and (3) variation at rs1761667 influenced oleic acid detection and fat taste perception. In a 3‐alternate forced choice test, 62% of participants detected 2.9 ± 0.7 mM oleic acid (or 0.08% w/v) in a 2.8% safflower oil emulsion. Supplementation of oleic acid did not enhance fattiness and creaminess perception for the cohort as a whole, though East Asians carrying the GG genotype perceived more overall fattiness and creaminess than their AA genotype counterparts (P < 0.001). No differences were observed for the Caucasians. These preliminary findings indicate that free oleic acid can be detected in an oil‐in‐water emulsion at concentrations found in commercial oils, but it does not increase fattiness or creaminess perception. Additionally, variation at rs1761667 may have ethnic‐specific effects on fat taste perception.

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Section: Discussionsupporting

confidence: 85%

Section: Sensory and Food Qualitysupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of CD36 Genotype on Oral Perception of Oleic Acid Supplemented Safflower Oil Emulsions in Two Ethnic Groups: A Preliminary Study

Burgess

Melis

Scoular

et al. 2018

Journal of Food Science

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show abstract

“…Recent studies have shown that the orosensory perception of dietary fat is an important factor in mediating fat intake [2, 7–14, 16–22, 24–30, 67]. Differences in the orosensory fat perception may also influence the susceptibility to develop diet-induced obesity [11, 22, 25, 46, 49, 50, 52, 68].…”

Section: Discussionmentioning

confidence: 99%

Lingual CD36 and nutritional status differentially regulate fat preference in obesity-prone and obesity-resistant rats

Braymer

Zachary

Schreiber

et al. 2017

Physiology & Behavior

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Lingual fatty acid receptors (i.e. CD36) mediate the orosensory perception of fat/fatty acids and may contribute to the susceptibility to develop obesity. The current study tested the hypothesis that fat/fatty acid preference in obesity-prone (OP, Osborne-Mendel) and obesity-resistant (OR, S5B/Pl) rats is mediated by nutritional status and lingual CD36. To determine if nutritional status affected linoleic acid (LA) preference in OP and OR rats, rats were either fasted overnight or fed a high fat diet (60% kcal from fat). In OR rats, fasting increased the preference for higher concentrations of LA (1.0%), while consumption of a high fat diet decreased LA preference. In OP rats, fasting increased the preference for lower concentrations of LA (0.25%), however high fat diet consumption did not alter LA preference. To determine if lingual CD36 mediated the effects of an overnight fast on LA preference, the expression of lingual CD36 mRNA was assessed and the effect of lingual application of CD36 siRNA on LA preference was determined. Fasting increased lingual CD36 mRNA expression in OR rats, but failed to alter lingual CD36 mRNA in OP rats. Following an overnight fast, application of lingual CD36 siRNA led to a decrease in LA preference in OR, but not OP rats. Lingual application of CD36 siRNA was also used to determine if lingual CD36 mediated the intake and preference for a high fat diet in OP and OR rats. CD36 siRNA decreased the preference and intake of high fat diet in OR rats, but not OP rats. The results from this study suggest that the dysregulation of lingual CD36 in OP rats is a potential factor leading to increased fat intake and fat preference and an enhanced susceptibility to develop obesity.

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Association of single nucleotide polymorphisms with taste and food preferences of the Hungarian general and Roma populations

et al. 2021

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Fatty acid translocase gene CD36 rs1527483 variant influences oral fat perception in Malaysian subjects

Cited by 17 publications

References 41 publications

Effects of CD36 Genotype on Oral Perception of Oleic Acid Supplemented Safflower Oil Emulsions in Two Ethnic Groups: A Preliminary Study

Effects of CD36 Genotype on Oral Perception of Oleic Acid Supplemented Safflower Oil Emulsions in Two Ethnic Groups: A Preliminary Study

Lingual CD36 and nutritional status differentially regulate fat preference in obesity-prone and obesity-resistant rats

Association of single nucleotide polymorphisms with taste and food preferences of the Hungarian general and Roma populations

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