Fatty Acid Profiles of Cerebrospinal Fluid Lipids in Normals and Chronic Alcoholics

Tichý, J; Alling, Christer; Dencker, S. J.; Svennerholm, Lars

doi:10.3109/00365517009049203

Cited by 13 publications

(7 citation statements)

References 18 publications

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“…These differences agree with those described by Tichy et al (10) for TG, PL, and CE and by Blomstrand (11) for CE. The fatty acid composition of CSF lipids differs from that of the plasma.…”

supporting

confidence: 93%

“…, TG, PL, and CE) in the human CSF (8- 10). The present investigation represents a quantitative and qualitative study of the fatty acids of the CSF and plasma lipids.…”

mentioning

confidence: 95%

“…(10) have recently speculated that in addition to the plasma and brain lipids, "the cells of CSF and the cells lining the CSF space might also be contributory. Tichy et QZ.…”

mentioning

confidence: 99%

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Fatty Acid Profiles of Various Lipids in the Cerebrospinal Fluid

Goto

Spitzer

1971

Experimental Biology and Medicine

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supporting

confidence: 93%

“…, TG, PL, and CE) in the human CSF (8- 10). The present investigation represents a quantitative and qualitative study of the fatty acids of the CSF and plasma lipids.…”

mentioning

confidence: 95%

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Fatty Acid Profiles of Various Lipids in the Cerebrospinal Fluid

Goto

Spitzer

1971

Experimental Biology and Medicine

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“…The concentration of sulfatide in CSF is 1/25 of that in serum (Fredman, Davidsson and Svennerholm, unpublished results) but the concentration of other serum lipids, phospholipids and cholesterol is only lj500 of that in serum (15). This suggests that the predominant portion of the CSF sulfatide orginates from the CNS.…”

Section: Resultsmentioning

confidence: 98%

Sulfatide as a biochemical marker in cerebrospinal fluid of patients with vascular dementia

Fredman

Wallin

Blennow

et al. 1992

Acta Neurologica Scandinavica

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The myelin-associated glycosphingolipid sulfatide in cerebrospinal fluid (CSF) was investigated in 20 patients with vascular dementia (VAD), 43 with Alzheimer's disease (AD) and 20 age-matched controls. The sulfatide concentration in the VAD group (307 +/- 118 nmol/l) was significantly (p less than 0.0001) higher than that in controls (145 +/- 86 nmol/l) and the AD group (178 +/- 79 nmol/l). Among the VAD patients, 8/20 had a significantly increased concentration of sulfatide (greater than mean + 2 S.D.), as compared with controls, while only 2/43 of the AD patients had a sulfatide concentration above this level. It is suggested that the elevated concentration of sulfatide in CSF from VAD patients reflects demyelination. Furthermore, sulfatide determinations, when combined with clinical findings, may be of diagnostic value, for discriminating between VAD and AD.

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“…The total lipid concentration was estimated to range from 10.3 to 12.5 μg.mL −1 (Irani 2009). Two major lipid families corresponding to phospholipids and cholesterol derivatives represent approximatively 80 % of total lipids in the CSF with concentrations close to 5 and 4 μg.mL −1 , respectively (Tourtellotte 1959;Tichy et al 1970;Illingworth and Glover 1971). Regarding phospholipids, lysolecithin (i.e., lysophosphatidylcholine, or LPC), lecithin (i.e., phosphatidylcholine, or PC), cephalin (i.e., phosphatidylethanolamine, or PE), and sphingomyelin species represent 6.7, 54, 17.6, and 20.3 % of total lipids in CSF, respectively.…”

Section: Analyses Of Normal Cerebrospinal Fluid Samplesmentioning

confidence: 99%

Lipidomic analysis of cerebrospinal fluid by mass spectrometry–based methods

Colsch

Seyer²,

Boudah

et al. 2014

J of Inher Metab Disea

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Lipids are natural substances found in all living organisms. Essential to the integrity of cell membranes, they also have many biological functions linked to energy storage and cell signaling, and are involved in a large number of heterogeneous diseases such as cancer, diabetes, neurological disorders, and inherited metabolic diseases. Lipids are challenging to analyze because of their huge structural diversity and numerous species. Up to now, lipid analysis has been achieved by targeted approaches focusing on selected families and relying on extraction protocols and chromatographic methods coupled to various detectors including mass spectrometry. Thanks to the technological improvements achieved in the fields of chromatography, high-resolution mass spectrometry and bioinformatics, it is possible to perform global lipidomic analyses enabling the concomitant detection, identification and relative quantification of many lipid species belonging to different families. The aim of this review is to focus on mass spectrometry-based methods to perform lipid and lipidomic analyses and on their application to the analysis of cerebrospinal fluid.

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Fatty Acid Profiles of Cerebrospinal Fluid Lipids in Normals and Chronic Alcoholics

Cited by 13 publications

References 18 publications

Fatty Acid Profiles of Various Lipids in the Cerebrospinal Fluid

Fatty Acid Profiles of Various Lipids in the Cerebrospinal Fluid

Sulfatide as a biochemical marker in cerebrospinal fluid of patients with vascular dementia

Lipidomic analysis of cerebrospinal fluid by mass spectrometry–based methods

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