Fatty acid oxidation drives hydrogen peroxide production by α-ketoglutarate dehydrogenase
Cathryn Grayson,
Ben Faerman,
Olivia Koufos
et al.
Abstract:Here, we conducted the first in-depth investigation into sex effects on mitochondrial hydrogen peroxide (mH2O2) generation in hepatic tissue. Female liver mitochondria produce less mH2O2when oxidizing pyruvate, palmitoyl-carnitine, and succinate when compared to male samples. This difference was attributed to superior coupling between fuel metabolism and oxidative phosphorylation (OxPhos) in female liver mitochondria. Examination of mH2O2production by individual sites of generation revealed that KGDH was a maj… Show more
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