Fatty acid-modified poly(glycerol adipate) microparticles for controlled drug delivery

Green synthesis and characterization of poly(glycerol‐azelaic acid) and its nanocomposites for applications in regenerative medicine

“…19 Over the past decade, numerous innovative products based on glycerol polyesters have been synthesized that are useful in various fields such as tissue engineering, drug delivery, and reconstructive surgery. [20][21][22][23][24][25][26] However, due to almost low-mechanical strength and fast degradation rate in vivo, 27,28 polyesters based on glycerol and ω-carboxy fatty acids commonly cannot independently present desirable properties for lots of biomedical application and tissue engineering purposes. To overcome these limitations and improve demanded properties in biomedical applications like biomimetic mechanical properties, researchers began to copolymerizing these bio-polyesters with other biomaterials or preparing their nanocomposites; it is well known that incorporating inorganic or organic nanofillers within the polymeric matrix can extend the polymer properties and brings distinctive characteristics.…”

Macro- and Nanoscale Effect of Ethanol on Bovine Serum Albumin Gelation and Naproxen Release

“…To counteract these deficiencies, controlled and sustained drug delivery systems, providing a constant and prolonged drug concentration, have been developed and have attracted significant attention [5]. Several systems, among them nanofibers [6,7], microparticles [8][9][10], smart polymers [11,12], hydrogels [13][14][15], nanocarriers [16], etc., have been explored for drug delivery applications.…”

Biobased poly(glycerol citrate) synthesis optimization via design of experiments

“…A significant advantage of linear PGAd is the possibility of later modifying unreacted hydroxyl groups to obtain polymers with entirely different properties. 42 The methods of obtaining glycerol polyesters available in the literature are often long, several hours long syntheses carried out at high temperatures. 43 However, the low cytotoxicity of these polymers, adequate degradation time, excellent biocompatibility in vitro and in vivo, and good mechanical properties make them highly attractive to tissue engineering and many other medical applications (e.g., biomaterials).…”

“…The selective esterification of the primary OH groups. A significant advantage of linear PGAd is the possibility of later modifying unreacted hydroxyl groups to obtain polymers with entirely different properties 42 …”